Hyperpigmentation in palms associated with lung adenocarcinoma resolving after chemotherapy

Wu, Fengying; Su, Chunxia; Liu, Li; Xu, Jianfang

doi:10.1111/crj.12226

Cited by 1 publication

(1 citation statement)

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“…For example, localized hyperpigmentation in palms that resolved after chemotherapy, myelodysplastic syndrome, coagulopathy (Trousseaus syndrome), hypoglycemia, hyponatremia, encephalomyelopathy, cerebellar degeneration, opsoclonus myoclonus ataxia, and Eaton-Lambert myastenic syndrome were the first clinical signs reported in lung carcinomas. 2 – 5 However, in very few cases, more than 2 paraneoplastic phenomena were reported to be associated.…”

Section: Introductionmentioning

confidence: 99%

A Coin-Like Peripheral Small Cell Lung Carcinoma Associated with Acute Paraneoplastic Axonal Guillain-Barre-Like Syndrome

et al. 2015

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A 65-year-old previously healthy male heavy smoker was hospitalized with a 2-week history of progressive muscle weakness in the lower and upper extremities. After 10 days of hospitalization, urinary sphincter incompetence and fecal incontinence were added and tetraparesis was established. The computer-tomography scan examination revealed a massive right hydrothorax and multifocal solid acinar structures with peripheral localization in the left lung, which suggested pulmonary cancer. Bone marrow metastases were also suspected. Based on the examination results, the final diagnosis was acute paraneoplastic axonal Guillain-Barre-like syndrome. The patient died 3 weeks after hospitalization. At autopsy, bronchopneumonia and a right hydrothorax were confirmed. Several 4 to 5-mm-sized round peripherally located white nodules were identified in the left lung, without any central tumor mass. Under microscope, a coin-shaped peripheral/subpleural small cell carcinoma was diagnosed, with generalized bone metastases. A huge thrombus in the abdominal aorta and acute pancreatitis was also seen at autopsy. This case highlights the difficulty of diagnosis of lung carcinomas and the necessity of a complex differential diagnosis of severe progressive ascending neuropathies. This is the 6th reported case of small cell lung cancer-associated acute Guillain-Barre-like syndrome and the first report about an association with a coin-like peripheral pattern.

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Section: Introductionmentioning

confidence: 99%

A Coin-Like Peripheral Small Cell Lung Carcinoma Associated with Acute Paraneoplastic Axonal Guillain-Barre-Like Syndrome

et al. 2015

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Hyperpigmentation in palms associated with lung adenocarcinoma resolving after chemotherapy

Abstract: The case reminds us that any skin disorders without obvious causes in heavy smokers should be alerted as a sign of lung cancer and sometimes could be used as a marker of response to the treatment.

Cited by 1 publication

References 7 publications

A Coin-Like Peripheral Small Cell Lung Carcinoma Associated with Acute Paraneoplastic Axonal Guillain-Barre-Like Syndrome

A Coin-Like Peripheral Small Cell Lung Carcinoma Associated with Acute Paraneoplastic Axonal Guillain-Barre-Like Syndrome

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