“…The reduction in total plasma phospholipid and selective decrease of phospholipid in HDL suggests that an early effect of human endoxemia is an alteration in the plasma input or clearance of HDL phospholipid. Since the decrease in HDL phospholipid occurred in all subclasses, mechanisms that shift the relative amounts of phospholipid subclasses, such as a decrease in the synthesis of PC (39), a decrease in PC and increase in LPC by secretory phospholipase A 2 (26,27,40,41), a decrease in SM by sphingomyelinase (28), or an increase in the biliary excretion of PC via the ABC membrane transporter, MDR3 P-glycoprotein (42), are less likely. Mechanisms that affect both cholesterol and phospholipid in HDL, such as an increase in the scavenger receptor class B type I scavenger receptor (43) or the ABC1 membrane transporter (44), are also less likely.…”