Hyperparathyroidism

Bogdonoff, Morton D.; Woods, Alexander H.; White, J.Earle; Engel, Frank L.

doi:10.1016/0002-9343(56)90074-2

Cited by 85 publications

(25 citation statements)

References 15 publications

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“…These included 27 individual case reports (3,5,(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(27)(28)(29)(30)(31)(32) and four case series (4,6,26,33). A summary of the literature search strategy is provided in Figure 1.…”

Section: Resultsmentioning

confidence: 99%

“…Primary hyperparathyroidism (4,7,19,24,27,29,33), connective tissue diseases (6,20,28), alcoholic liver disease (9,11,13,14,16,22), and malignancies (5,15,17,21,23,30,31) were the most common causes of NUC (Table 1). Diabetes (26), chemotherapy-induced (cyclophosphamide, Adriamycin, and fluorouracil) protein C and S deficiency (18), Crohn disease (3), POEMS syndrome (12), vitamin D deficiency (10), weight loss (25), chronic kidney disease (not ESKD) (32), and osteomalacia treated with nadroparin calcium (8) were the remaining reported etiologic conditions.…”

Section: Resultsmentioning

confidence: 99%

“…Diabetes (26), chemotherapy-induced (cyclophosphamide, Adriamycin, and fluorouracil) protein C and S deficiency (18), Crohn disease (3), POEMS syndrome (12), vitamin D deficiency (10), weight loss (25), chronic kidney disease (not ESKD) (32), and osteomalacia treated with nadroparin calcium (8) were the remaining reported etiologic conditions. In 22 cases, corticosteroid use was an associated predisposing factor (3,6,7,12,13,20,21,23,28,30,33), warfarin use was reported in nine cases (5,6,31), albumin or blood transfusions were reported in seven cases (4,9,(12)(13)(14)(15)19), and protein C or S deficiency was reported in four cases (9,16,18,20). Precipitating trauma leading to cutaneous lesions was reported in only two cases (10,21).…”

Section: Resultsmentioning

confidence: 99%

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Calciphylaxis from Nonuremic Causes

Nigwekar

Wolf²,

Sterns

et al. 2008

Clinical Journal of the American Society of Nephrology

370

396

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Background and objectives: Calciphylaxis, or calcific uremic arteriolopathy, is a well-described entity in end-stage kidney disease and renal transplant patients; however, little systematic information is available on calciphylaxis from nonuremic causes. This systematic review was designed to characterize etiologies, clinical features, laboratory abnormalities, and prognosis of nonuremic calciphylaxis.Design, setting, participants, & measurements: A systematic review of literature for case reports and case series of nonuremic calciphylaxis was performed. Cases included met the operational definition of nonuremic calciphylaxis-histopathologic diagnosis of calciphylaxis in the absence of end-stage kidney disease, renal transplantation, or acute kidney injury requiring renal replacement therapy.Results: We found 36 cases (75% women, 63% Caucasian, aged 15 to 82 yr) of nonuremic calciphylaxis. Primary hyperparathyroidism, malignancy, alcoholic liver disease, and connective tissue disease were the most common reported causes. Preceding corticosteroid use was reported for 61% patients. Protein C and S deficiencies were seen in 11% of patients. Skin lesions were morphologically similar to calcific uremic arteriolopathy. Mortality rate was 52%, with sepsis being the leading cause of death.Conclusion: Calciphylaxis should be considered while evaluating skin lesions in patients with predisposing conditions even in the absence of end-stage kidney disease and renal transplantation. Nonuremic calciphylaxis is reported most often in white women. Mineral abnormalities that are invoked as potential causes in calcific uremic arteriolopathy are often absent, suggesting that heterogeneous mechanisms may contribute to its pathogenesis. Nonuremic calciphylaxis is associated with high mortality, and there is no known effective treatment.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Calciphylaxis from Nonuremic Causes

Nigwekar

Wolf²,

Sterns

et al. 2008

Clinical Journal of the American Society of Nephrology

370

396

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“…Other workers (Schaaf and Kyle, 1954;Nordin and Fraser, 1956;Bogdonoff, Woods, White, and Engel, 1956;Goldman et al, 1957;Kyle, Schaaf, and Canary, 1958) have now described a variety of tests for renal handling of phosphate, with the suggestion that these are of real significance in the positive identification or exclusion of primary hyperparathyroidism.…”

mentioning

confidence: 99%

“…In the patient to be described, with a proved parathyroid adenoma, the pre-operative renal handling of phosphate, as measured by several of the published tests (Bogdonoff et al, 1956;Goldman et al, 1957;Kyle et al, 1958;Nordin, 1958) The chemical findings included persistent hypercalcaemia and normal plasma phosphorus levels. The blood urea and plasma electrolytes were normal and there was no proteinuria.…”

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confidence: 99%

Parathyroid Adenoma With Misleading Phosphate Excretion Tests

Morgan¹,

Stewart²,

Grieve³

1960

J Clin Pathol

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A patient with primary hyperparathyroidism is described in whom, pre-operatively, the renal tubular handling of phosphate was within the limits accepted by recent writers as normal. The tests they advocate were, therefore, shown to be unreliable in this disease. The hypercalcaemia of primary hyperparathyroidism is one type of hypercalcaemia that is apparently not reduced to normal after the administration of an adequate dosage of cortisone. In our patient, such a " cortisone-fast " finding is documented, and was a valuable aid in the decision to operate.

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Free amino acid levels in amyotrophic lateral sclerosis

Patten

Harati

Acosta

et al. 1978

Annals of Neurology

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To evaluate reports of abnormal levels of free amino acids (AA) in patients with amyotrophic lateral sclerosis (ALS), we studied serum, cerebrospinal fluid, and urine AA in 12 patients with ALS and 12 controls matched for age, sex, and severity of disability. ALS patients had statistically significant elevations in serum levels of tyrosine, total aromatic AA, and total basic AA. ALS patients also had statistically significant elevations in cerebrospinal fluid of total basic AA, lysine, essential AA, and leucine. The severity of ALS correlated inversely with acidic AA (glutamate and aspartate) and O-phosphoserine in cerebrospinal fluid. Activity of ALS correlated directly with serum aspartate and cerebrospinal fluid alanine. We conclude that subtle abnormalities of AA levels are present in ALS and that these are not due to age, sex, or disability. The pattern of distribution of AA levels differs from that in hepatic or renal disease and suggests defective membrane transport or poor cellular utilization of basic and essential AA in the central nervous system.

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Hyperparathyroidism

Cited by 85 publications

References 15 publications

Calciphylaxis from Nonuremic Causes

Calciphylaxis from Nonuremic Causes

Parathyroid Adenoma With Misleading Phosphate Excretion Tests

Free amino acid levels in amyotrophic lateral sclerosis

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