Hyperparathyroidism and vessel diseases

Zandifar, Samaneh; Mardanparvar, Hossein; Mohammadi, Saeid; Dehghan, Sara

doi:10.34172/jpd.2023.11217

J Parathyr Dis

2023

DOI: 10.34172/jpd.2023.11217

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Hyperparathyroidism and vessel diseases

Samaneh Zandifar

Hossein Mardanparvar

Saeid Mohammadi

et al.

Abstract: Hyperparathyroidism is a condition where the parathyroid glands produce excess parathyroid hormone, increasing calcium levels in the blood. Chronic hypercalcemia due to hyperparathyroidism has been linked with an increased risk of cardiovascular disease and other vascular complications such as hypertension, atherosclerosis, and thrombosis.

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Hyperparathyroidism and Peripheral Arterial Disease

Antignani,

Jezovnik,

Blinc

et al. 2024

CVP

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Primary hyperparathyroidism (PHPT) is presented in various forms, including classic PHPT, characterised by increased parathyroid hormone (PTH) secretion, normohormonal PHPT, and normocalcaemic PHPT. Secondary hyperparathyroidism is characterised by increased PTH secretion triggered by factors such as vitamin D deficiency and kidney failure. This review aims to discuss the involvement of hyperparathyroidism (HPT) in atherosclerosis, including peripheral arterial disease (PAD). The increased level of PTH is involved in developing subclinical and overt vascular diseases, encompassing endothelial dysfunction, vascular stiffness, hypertension, and coronary and peripheral arterial diseases. It has been consistently associated with an augmented risk of cardiovascular morbidity and mortality, independent of classical risk factors for atherosclerosis. Chronic hypercalcemia associated with increased levels of PTH contributes to the development of calcification of vessel walls and atherosclerotic plaques. Vascular calcification can occur in the intima or media of the arterial wall and is associated with stiffness of peripheral arteries, which the formation of atherosclerotic plaques and narrowing of the vessel lumen can follow. For treating hyperparathyroidism, particularly SHPT, calcimimetics, novel phosphorus binders and novel vitamin D receptor activators are used. However, they are ineffective in severe PHPT. Therefore, parathyroidectomy remains the primary therapeutic option of PHPT.

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Hyperparathyroidism and Peripheral Arterial Disease

Antignani,

Jezovnik,

Blinc

et al. 2024

CVP

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Hyperparathyroidism and vessel diseases

Cited by 1 publication

References 18 publications

Hyperparathyroidism and Peripheral Arterial Disease

Hyperparathyroidism and Peripheral Arterial Disease

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