Hyperoxic Ventilation in Critical Dilutional Anemia: Intestinal O<sub>2</sub> Transport and Tissue Oxygenation

Kemming, Gregor; Meisner, Franz; Kleen, M.; Meier, Jens; Tillmanns, Jochen; Hutter, Jörg; Wojtczyk, Christoph J.; Packert, K.B.; Bottino, Daniel; Häbler, O.

doi:10.1111/j.1778-428x.2004.tb00091.x

Cited by 9 publications

(5 citation statements)

References 32 publications

(39 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This practice will assist in avoidance of overtransfusion and prevention of associated complications including transfusionassociated circulatory overload and pulmonary edema. The exception to this case may be in the patient with critical anemia (Hb at which the compensatory responses [including increased cardiac output, redistribution of regional organ blood flows, and enhanced tissue oxygen extraction] fail to preserve adequate tissue oxygenation and tissue hypoxia ensues) (95), in which Ն1 RBC unit may be indicated.…”

Section: (Level 2)mentioning

confidence: 97%

Clinical practice guideline: Red blood cell transfusion in adult trauma and critical care*

Napolitano

Kurek

Luchette

et al. 2009

Critical Care Medicine

442

222

View full text Add to dashboard Cite

show abstract

Section: (Level 2)mentioning

confidence: 97%

Clinical practice guideline: Red blood cell transfusion in adult trauma and critical care*

Napolitano

Kurek

Luchette

et al. 2009

Critical Care Medicine

442

222

View full text Add to dashboard Cite

show abstract

“…Trotz seiner geringen O 2 -Löslichkeit in Plasma wird der physikalisch gelöste O 2 bei Verdünnungsan-ämie zu einer für die Gewebeoxygenierung höchst relevanten biologischen Grö-ße und deckt in dieser Situation bis zu 75% des Gesamtkörper-O 2 -Bedarfs [35]. Experimentelle und klinischen Studien zeigen, dass hyperoxische Beatmung die Anämie-toleranz signifikant steigert [35,63,69,81] und dadurch einen Sicherheitsbereich für die globale [35,36,63,83], myokardiale [34,35,48,62], gastrointestinale [46] und zerebrale [91,92] Gewebeoxygenierung schafft. Im Tierexperiment sicherte hyperoxische Beatmung das Überleben an der Hb krit für mehr als 6 h, während mit Raumluft beatmete Kontrolltiere innerhalb von 15 min bis 3 h verstarben [63].…”

Section: Inspiratorische Sauerstofffraktionunclassified

Perioperatives Management bei Zeugen Jehovas

Häbler

Voß

2010

Anaesthesist

View full text Add to dashboard Cite

The religious organization of Jehovah's Witnesses numbers more than 7 million members worldwide, including 165,000 members in Germany. Although Jehovah's Witnesses strictly refuse the transfusion of allogeneic red blood cells, platelets and plasma, Jehovah's Witness patients may nevertheless benefit from modern therapeutic concepts including major surgical procedures without facing an excessive risk of death. The present review describes the perioperative management of surgical Jehovah's Witness patients aiming to prevent fatal anemia and coagulopathy. The cornerstones of this concept are 1) education of the patient about blood conservation techniques generally accepted by Jehovah's Witnesses, 2) preoperative optimization of the cardiopulmonary status and correction of preoperative anemia and coagulopathy, 3) perioperative collection of autologous blood, 4) minimization of perioperative blood loss and 5) utilization of the organism's natural anemia tolerance and its acute accentuation in the case of life-threatening anemia.

show abstract

“…It has been demonstrated that the hemodilution‐induced decline of systemic vascular resistance re‐increases after the onset of hyperoxic ventilation without reaching its baseline level (Figure 3). 1,18 Despite its low solubility in plasma, physically dissolved oxygen becomes an biologically relevant oxygen source in this situation, which covers up to 75% of whole body VO 2 18–20,37,38 …”

Section: Hyperoxic Ventilation During Moderate Anemiamentioning

confidence: 99%

“…It has been demonstrated in several animal experiments that animals ventilated with pure oxygen tolerate considerably lower hemoglobin concentrations than animals ventilated with room air 18,39–41 . The resulting hyperoxemia creates a margin of safety for myocardial, 18,41,42 intestinal 37 and cerebral tissue oxygenation 43,44 …”

Section: Hyperoxic Ventilation During Moderate Anemiamentioning

confidence: 99%

The effects of hyperoxic ventilation on tissue oxygenation

Meier

Lauscher

Kertscho

et al. 2010

Transfus Alt Transfus Med

View full text Add to dashboard Cite

SUMMARY Application of high inspiratory oxygen concentrations is an established method to improve arterial oxygen content, oxygen transport and tissue oxygenation. However, in the past years a considerable amount of data have emerged challenging this approach: hyperoxic ventilation (ventilation with pure oxygen, HV) and subsequent hyperoxemia have been accused of inducing unfavorable effects on microcirculation and tissue perfusion, resulting in regional tissue hypoxia. Interestingly, these disadvantegous properties of HV seem to occur predominantly in patients with physiological hemoglobin concentrations and probably play a minor role in anemic patients. In animal experiments the effect of HV on tissue oxygenation and on outcome of several severe pathologic conditions essentially depends on the hemoglobin concentration: HV failed to have a considerable impact on survival of severe hypovolemia or methemoglobinemia (physiological hemoglobin concentration), whereas it convincingly improves outcome of severe normovolemic anemia. The present review discusses a perspective on the effects of HV at different hemoglobin concentrations and its potential to improve oxygen transport and tissue oxygenation especially during moderate and severe anemia.

show abstract

Hyperoxic Ventilation in Critical Dilutional Anemia: Intestinal O₂ Transport and Tissue Oxygenation

Cited by 9 publications

References 32 publications

Clinical practice guideline: Red blood cell transfusion in adult trauma and critical care*

Clinical practice guideline: Red blood cell transfusion in adult trauma and critical care*

Perioperatives Management bei Zeugen Jehovas

The effects of hyperoxic ventilation on tissue oxygenation

Contact Info

Product

Resources

About

Hyperoxic Ventilation in Critical Dilutional Anemia: Intestinal O2 Transport and Tissue Oxygenation

Cited by 9 publications

References 32 publications

Clinical practice guideline: Red blood cell transfusion in adult trauma and critical care*

Clinical practice guideline: Red blood cell transfusion in adult trauma and critical care*

Perioperatives Management bei Zeugen Jehovas

The effects of hyperoxic ventilation on tissue oxygenation

Contact Info

Product

Resources

About

Hyperoxic Ventilation in Critical Dilutional Anemia: Intestinal O₂ Transport and Tissue Oxygenation