Hyperoxia-Induced Protection against Rat's Renal Ischemic Damage: Relation to Oxygen Exposure Time

Wahhabaghai, Hannaneh; Rasoulian, Bahram; Esmaili, Mansour; Mehrani, Hossein; Mohammadhosseniakbari, Hassan; Mofid, Mahmood; Jafari, Mahvash; Noroozi, Majid; Foadoddini, Mohsen; Asgai, Alireza; Khoshbaten, Ali

doi:10.1080/08860220902963863

Cited by 12 publications

(10 citation statements)

References 31 publications

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“…In addition, it has been shown that oxygen preconditioning can protect human renal tubular cells from cisplatin-induced cytotoxicity in vitro [5]. Likewise, in animal models, oxygen pretreatment reduces ischemia-reperfusion injuries in various vital organs such as the central nervous system [18–21], liver [22, 23], heart [24], and kidney [25, 26]. Moreover, it has been reported that hyperoxic preconditioning could attenuate hypoxia-induced apoptosis in cultured mesenchymal stem cells [27].…”

Section: Resultsmentioning

confidence: 99%

Cellular Preoxygenation Partially Attenuates the Antitumoral Effect of Cisplatin despite Highly Protective Effects on Renal Epithelial Cells

Rasoulian

Kaeidi

Rezaei

et al. 2017

Oxidative Medicine and Cellular Longevity

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Our previous in vitro studies demonstrated that oxygen pretreatment significantly protects human embryonic renal tubular cell against acute cisplatin- (CP-) induced cytotoxicity. The present study was designed to investigate whether this protective effect is associated with decreasing therapeutic effects of cisplatin on malignant cells. For this purpose, cultured human embryonic kidney epithelial-like (AD293), cervical carcinoma epithelial-like (Hela), and ovarian adenocarcinoma epithelial-like (OVCAR-3) cells were subjected to either 2-hour pretreatment with oxygen (≥90%) or normal air and then to a previously determined 50% lethal dose of cisplatin for 24 hours. Cellular viability was evaluated via MTT and Neutral Red assays. Also, activated caspase-3 and Bax/Bcl-2 ratio, as the biochemical markers of cell apoptosis, were determined using immunoblotting. The hyperoxic preexposure protocol significantly protects renal AD293 cells against cisplatin-induced toxicity. Oxygen pretreatment also partially attenuated the cisplatin-induced cytotoxic effects on Hela and OVCAR-3 cells. However, it did not completely protect these cells against the therapeutic cytotoxic effects of cisplatin. In summary, the protective methods for reducing cisplatin nephrotoxic side effects like oxygen pretreatment might be associated with concurrent reduction of the therapeutic cytotoxic effects of cisplatin on malignant cells like cervical carcinoma (Hela) and ovarian adenocarcinoma (OVCAR-3) cells.

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Section: Resultsmentioning

confidence: 99%

Cellular Preoxygenation Partially Attenuates the Antitumoral Effect of Cisplatin despite Highly Protective Effects on Renal Epithelial Cells

Rasoulian

Kaeidi

Rezaei

et al. 2017

Oxidative Medicine and Cellular Longevity

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“…Rasoulian et al [21] and Wahhabaghai et al [22] showed that intermittent pre-exposure to hyperoxic environment can reduce subsequent renal ischemic injury in rats.…”

Section: Discussionmentioning

confidence: 99%

“…Donor hyperoxia might induce good early postoperative liver function by improving ATP hepatic content, increasing protein synthesis, and decreasing the proteolytic process in the liver. It was also proposed that donor hyperoxia could be valuable, as it has been demonstrated experimentally that hyperoxic pretreatment attenuates ischemic-reperfusion injury of the heart [18, 47], brain [19, 48], spinal cord [20], liver [49], and kidney [21, 22]. …”

Section: Discussionmentioning

confidence: 99%

“…In animal models, the protective effects of oxygen pretreatment on subsequent ischemia-reperfusion injury have been confirmed in heart [17, 18], brain [19], spinal cord [20], and finally kidney [21, 22]. …”

Section: Introductionmentioning

confidence: 99%

“…Wahhabaghai and colleagues [22] showed that repeated exposure to hyperoxic (≥95% O 2 ) environment can decrease rat's renal ischemia-reperfusion damage.…”

Section: Introductionmentioning

confidence: 99%

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Short-Time Intermittent Preexposure of Living Human Donors to Hyperoxia Improves Renal Function in Early Posttransplant Period: A Double-Blind Randomized Clinical Trial

Montazeri

Vakily

Honarmand

et al. 2011

Journal of Transplantation

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The purpose of this human study was to investigate the effect of oxygen pretreatment in living kidney donors on early renal function of transplanted kidney. Sixty living kidney donor individuals were assigned to receive either 8–10 L/min oxygen (Group I) by a non-rebreather mask with reservoir bag intermittently for one hour at four times (20, 16, 12, and 1 hours before transplantation) or air (Group II). After kidney transplantation, urine output, blood urea nitrogen (BUN), serum creatinine, need to additional diuretics (NTADs) in the first 24 hours after transplantation, delayed graft function (DGF), the creatinine clearance (CrCL) on 10th day, and duration of hospital stay from the first posttransplant day till normalization of renal function was recorded and compared in two groups. Mean CrCL in posttransplant day 10, NTAD after 24 hours of transplantation, and urine output during 6 hours after operation were significantly better in Group I compared with Group II (P < .05). Also, DGF during the first week after operation and duration of hospital stay was less in Group I compared with Group II. Intermittent exposure of human living kidney donor to hyperoxic environment may improve renal function following kidney transplantation.

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Inhibition of USP14 Suppresses ROS-dependent Ferroptosis and Alleviates Renal Ischemia/Reperfusion Injury

Zhao¹,

Li²,

Xu³

et al. 2022

Cell Biochem Biophys

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Hyperoxia-Induced Protection against Rat's Renal Ischemic Damage: Relation to Oxygen Exposure Time

Cited by 12 publications

References 31 publications

Cellular Preoxygenation Partially Attenuates the Antitumoral Effect of Cisplatin despite Highly Protective Effects on Renal Epithelial Cells

Cellular Preoxygenation Partially Attenuates the Antitumoral Effect of Cisplatin despite Highly Protective Effects on Renal Epithelial Cells

Short-Time Intermittent Preexposure of Living Human Donors to Hyperoxia Improves Renal Function in Early Posttransplant Period: A Double-Blind Randomized Clinical Trial

Inhibition of USP14 Suppresses ROS-dependent Ferroptosis and Alleviates Renal Ischemia/Reperfusion Injury

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