2020
DOI: 10.1038/s41598-020-77915-0
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Hyperoxia in portal vein causes enhanced vasoconstriction in arterial vascular bed

Abstract: Long-term perfusion of liver grafts outside of the body may enable repair of poor-quality livers that are currently declined for transplantation, mitigating the global shortage of donor livers. In current ex vivo liver perfusion protocols, hyperoxic blood (arterial blood) is commonly delivered in the portal vein (PV). We perfused porcine livers for one week and investigated the effect of and mechanisms behind hyperoxia in the PV on hepatic arterial resistance. Applying PV hyperoxia in porcine livers (n = 5, ar… Show more

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Cited by 9 publications
(17 citation statements)
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References 36 publications
(67 reference statements)
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“…This dual blood supply would suggest that the PV system also has to be oxygenated, which is the case in some perfusion machines (13,40,41). On the other hand, it is also important to avoid hyperoxygenation in the PV, as this leads to increased resistance and reduced flows in both the PV and the HA (42)(43)(44). It has been suggested that the endothelium plays a central role in the underlying mechanisms which causes this vasoconstriction due to hyperoxia, although the true mechanism is still unknown (43,44).…”
Section: Oxygenatorsmentioning
confidence: 99%
See 3 more Smart Citations
“…This dual blood supply would suggest that the PV system also has to be oxygenated, which is the case in some perfusion machines (13,40,41). On the other hand, it is also important to avoid hyperoxygenation in the PV, as this leads to increased resistance and reduced flows in both the PV and the HA (42)(43)(44). It has been suggested that the endothelium plays a central role in the underlying mechanisms which causes this vasoconstriction due to hyperoxia, although the true mechanism is still unknown (43,44).…”
Section: Oxygenatorsmentioning
confidence: 99%
“…On the other hand, it is also important to avoid hyperoxygenation in the PV, as this leads to increased resistance and reduced flows in both the PV and the HA (42)(43)(44). It has been suggested that the endothelium plays a central role in the underlying mechanisms which causes this vasoconstriction due to hyperoxia, although the true mechanism is still unknown (43,44). To avoid hyperoxia in liver perfusion, an arterioportal shunt is sometimes used to mix blood from the oxygenator and blood from the VC outflow to supply more physiologically oxygenated blood to the PV (42,43).…”
Section: Oxygenatorsmentioning
confidence: 99%
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“…1,4 We recently introduced a unique liver perfusion technology that maintains human livers viable and in a metabolically active state for up to one week (Figure 1). 4,[9][10][11][12][13] With this device, it is possible to perfuse and observe/assess livers prior transplantation at close to physiological conditions for up to one week.…”
Section: Introductionmentioning
confidence: 99%