Hyperoxia During Septic Shock—Dr. Jekyll or Mr. Hyde?

Asfar, Pierre; Calzia, Enrico; Huber‐Lang, Markus; Ignatius, Anita; Radermacher, Peter

doi:10.1097/shk.0b013e318238c991

Cited by 12 publications

(8 citation statements)

References 9 publications

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“…Thus, mitochondria have a key role in host defense by guiding PMNs to sites of infection. Consequently, conditions that impair mitochondrial function should weaken host defense, a notion that is supported by studies that have demonstrated an increased risk of sepsis in patients with hypoxia and mitochondrial dysfunction (van den Berghe et al, 2001;Kozlov et al, 2011;Asfar et al, 2012;Waisman et al, 2012). Mitochondria generate ATP by oxidative phosphorylation, which requires an energy source and O 2 as electron acceptor.…”

Section: Discussionmentioning

confidence: 82%

mTOR and differential activation of mitochondria orchestrate neutrophil chemotaxis

Bao¹,

Ledderose²,

Graf³

et al. 2015

J Exp Med

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Section: Discussionmentioning

confidence: 82%

mTOR and differential activation of mitochondria orchestrate neutrophil chemotaxis

Bao¹,

Ledderose²,

Graf³

et al. 2015

J Exp Med

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“…It is well known that early goal-directed therapy for MODS aims to balance oxygen delivery and demand (24,25). Previous animal studies have shown that hyperoxia exposure can improve organ function and survival rate in several models of shock or sepsis (4)(5)(6)(7)(8)26,27). In addition, 100% oxygen exposure for 2 and 3 h starting at 4 and 12 h, respectively, after ZY injection benefits the outcome of mice with sterile sepsis (8).…”

Section: Discussionmentioning

confidence: 97%

“…In addition, 100% oxygen exposure for 2 and 3 h starting at 4 and 12 h, respectively, after ZY injection benefits the outcome of mice with sterile sepsis (8). It is speculated that improved tissue oxygenation and decreased systemic inflammatory response are crucially involved in the protective effects of hyperoxia treatment (4)(5)(6)(7)(8). However, hyperoxia treatment can induce the production of ROS, which are considered to be associated with oxygen toxicity (9,10).…”

Section: Discussionmentioning

confidence: 97%

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Combination therapy of molecular hydrogen and hyperoxia improves survival rate and organ damage in a zymosan-induced generalized inflammation model

Hong

Sun

et al. 2016

Experimental and Therapeutic Medicine

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Multiple organ dysfunction syndrome (MODS) is a leading cause of mortality in critically ill patients. Hyperoxia treatment may be beneficial to critically ill patients. However, the clinical use of hyperoxia is hindered as it may exacerbate organ injury by increasing reactive oxygen species (ROS). Hydrogen gas (H) exerts a therapeutic antioxidative effect by selectively reducing ROS. Combination therapy of H and hyperoxia has previously been shown to significantly improve survival rate and organ damage extent in mice with polymicrobial sepsis. The aim of the present study was to investigate whether combination therapy with H and hyperoxia could improve survival rate and organ damage in a zymosan (ZY)-induced generalized inflammation model. The results showed that the inhalation of H (2%) or hyperoxia (98%) alone improved the 14-day survival rate of ZY-challenged mice from 20 to 70 or 60%, respectively. However, combination therapy with H and hyperoxia could increase the 14-day survival rate of ZY-challenged mice to 100%. Furthermore, ZY-challenged mice showed significant multiple organ damage characterized by increased serum levels of aspartate transaminase, alanine transaminase, blood urea nitrogen and creatinine, as well as lung, liver and kidney histopathological scores at 24 h after ZY injection. These symptoms where attenuated by H or hyperoxia alone; however, combination therapy with H and hyperoxia had a more marked beneficial effect against lung, liver and kidney damage in ZY-challenged mice. In addition, the beneficial effects of this combination therapy on ZY-induced organ damage were associated with decreased serum levels of the oxidative product 8-iso-prostaglandin F2α, increased activity of superoxide dismutase and reduced levels of the proinflammatory cytokines high-mobility group box 1 and tumor necrosis factor-α. In conclusion, combination therapy with H and hyperoxia provides enhanced therapeutic efficacy against multiple organ damage in a ZY-induced generalized inflammation model, suggesting the potential applicability of H and hyperoxia in the therapy of conditions associated with inflammation-related MODS.

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“…Blood lactate level was the earliest discriminator of survival. Using univariate logistic regression, lactate discriminated survivors from those who died at 12 and 24 h after admission, but not at 48 h (p = 0.049, 0.044 and 0.062, respectively [48,49].…”

Section: Lactatementioning

confidence: 99%

Sepsis in Children

Mendez¹

2015

ETS

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Hyperoxia During Septic Shock—Dr. Jekyll or Mr. Hyde?

Cited by 12 publications

References 9 publications

mTOR and differential activation of mitochondria orchestrate neutrophil chemotaxis

mTOR and differential activation of mitochondria orchestrate neutrophil chemotaxis

Combination therapy of molecular hydrogen and hyperoxia improves survival rate and organ damage in a zymosan-induced generalized inflammation model

Sepsis in Children

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