Hyperoxaluria and urinary tract calculi after jejunoileal bypass

Fikri, Erden; Casella, Roberto

doi:10.1016/0002-9610(75)90253-6

Cited by 5 publications

(1 citation statement)

References 6 publications

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“…Paradoxically, resection of an extensive amount of distal ileum results in increased oxalate absorption and hyperoxaluria Stauffer et al, 1973;Earnest et al, 1974). Hyperoxaluria has also been described in other patients with a variety of intestinal diseases, including small bowel bypass (Dickstein and Frame, 1973;O'Leary et al, 1974;Fikri and Casella, 1975), pancreatic insufficiency (Stauffer et al, 1974), intestinal pseudo-obstruction (Smith et al, 1972), Crohn's disease (Dowling et al, 1971;Smith et al, 1972;Earnest et al, 1973), and coeliac sprue (Smith et al, 1972;Stauffer etal., 1974). In this diverse group of diseases, malabsorption of fat appears to be the common denominator associated with excessive absorption of dietary oxalate.…”

Section: Relationship Between Faecal Fat and Urinary Oxalate And Calcmentioning

confidence: 98%

Hyperoxaluria correlates with fat malabsorption in patients with sprue.

McDonald¹,

Earnest²,

Admirand³

1977

Gut

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SUMMARY The effect of fat malabsorption on the absorption and renal excretion of dietary oxalate was studied in four patients with sprue and in two patients with dermatitis herpetiformis and spruelike jejunal histology. Hyperoxaluria was present in all patients with sprue when fat malabsorption was severe. Urinary oxalate excretion decreased in two of the three patients with coeliac sprue when their fat malabsorption had improved after three months of dietary gluten restriction. Neither patient with dermatitis herpetiformis and sprue had steatorrhoea. In these patients, urinary oxalate excretion was always within normal limits. A significant positive linear relationship (y = 28*25 + 4 84x; r = 0-82; p < 0.01) was demonstrated between faecal fat and urinary oxalate excretion. The results of this study support the concept that severe malabsorption of dietary fat plays a primary causative role in enteric hyperoxaluria.

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Section: Relationship Between Faecal Fat and Urinary Oxalate And Calcmentioning

confidence: 98%

Hyperoxaluria correlates with fat malabsorption in patients with sprue.

McDonald¹,

Earnest²,

Admirand³

1977

Gut

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Bacterial Flora of the Small Bowel Before and After Bypass Procedure for Morbid Obesity

Corrodi¹,

Wideman²,

Sutter³

et al. 1978

Journal of Infectious Diseases

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The contents of the proximal jejunum and distal ileum were cultured quantitatively in eight patients who were undergoing intestinal bypass procedure for obesity. Five jejunal specimens were sterile, and three contained low counts of a predominantly aerobic flora. Ileal contents yielded variable but usually higher counts than in the jejunum, and there were similar numbers of anaerobes and aerobes. In three patients in whom a bypass was established, contents of the functioning small bowel showed counts of 10(5.0)-10(7.6) colony-forming units/ml. These counts exceeded the counts in the normal terminal ileum, and the flora qualitatively resembled that of feces. Four specimens from excluded loops revealed colonization with fecal organisms, and the counts ranged between 10(6.4) and 10(9.7) colony-forming units/ml. In jejunoileal bypass both the functioning small bowel and the excluded loop become colonized with colonic flora, a phenomenon that may contribute to some of the side effects of this procedure.

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Renal complications of jejuno-ileal bypass for obesity

Mole

Tomson²,

Mortensen³

et al. 2001

QJM

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Jejuno-ileal bypass has until recently been an accepted treatment for refractory morbid obesity. Although hyperoxaluria causing renal tract calculi is a well-recognized complication, we describe eight patients who developed significant renal failure attributable to hyperoxaluria resulting from this procedure, three requiring renal replacement therapy. We review the literature, describing 18 other cases with renal failure, the mechanisms of hyperoxaluria and its treatment. Because reversal of the bypass may result in stabilization or partial improvement of renal function, these patients require long-term follow-up of renal function.

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Hyperoxaluria and urinary tract calculi after jejunoileal bypass

Cited by 5 publications

References 6 publications

Hyperoxaluria correlates with fat malabsorption in patients with sprue.

Hyperoxaluria correlates with fat malabsorption in patients with sprue.

Bacterial Flora of the Small Bowel Before and After Bypass Procedure for Morbid Obesity

Renal complications of jejuno-ileal bypass for obesity

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