Hyperosmolality, High Blood Pressure, and Decreased Estimated Glomerular Filtration Rate in US Adolescents, National Health and Nutrition Examination Survey 1999–2012

Chmielewski, J; Khalsa, Dev Darshan; Carmody, John

doi:10.1159/000497780

Cited by 3 publications

(1 citation statement)

References 42 publications

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“…For example an imbalance of salt and water contribute to hypertension and chronic kidney disease. Hypernatremia and hyperosmolality is associated with high systolic blood pressure and decreased estimated glomerular filtration rate [15] . Osmolality depends on the number of osmotically active particles dissolved per kilogram of pure water (mOsm/kg H 2 O) [16] .…”

Section: Discussionmentioning

confidence: 99%

The accuracy of serum osmolarity calculation in small children

Berska¹,

Bugajska²,

Sztefko³

2023

J Med Biochemistry

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Background. Serum osmolality can be measured (Omeas) or calculated (Ocal). Many formulas for Ocal have been already published, but data regarding the most accurate equation in small babies is not available. Thus, we aim to compare Omeas and Ocal obtained by different formulas in newborns and small children. Methods. The study included 280 serum samples taken from children, from the first day of life to 2 years (mean age 8.2 ± 7.6 months) treated in the University Children’s Hospital in Krakow. The serum osmolality was measured by osmometer and calculated by 8 common formulas. Results. The mean value of Omeas (285.8±5.1 mOsm/kgH2O) was significantly different as compared to the mean values of Ocal (p<0.01) for all formulas, except Ocal obtained by the formula: 1.86*(Na+K)+1.15*Glu+Urea+14. According to Bland-Altman analysis, this formula showed the best performance for estimating osmolality. In children under 3 months of life Passing-Bablok regression indicated both systematic and proportional error for results obtained by each formula compared to the measured values. Conclusions. To calculate osmolarity in children aged between 3 months and 2 years old the following equations: 1.86*(Na+K)+1.15*Glu+Urea+14 might be used, whereas serum osmolality in children up to 3 month of life should be measured.

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Section: Discussionmentioning

confidence: 99%

The accuracy of serum osmolarity calculation in small children

Berska¹,

Bugajska²,

Sztefko³

2023

J Med Biochemistry

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Association of serum osmolality with all-cause and cardiovascular mortality in US adults: A prospective cohort study

Wang¹,

Zhao²,

Yang³

et al. 2023

Nutrition, Metabolism and Cardiovascular Diseases

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Underhydration Is Associated with Obesity, Chronic Diseases, and Death Within 3 to 6 Years in the U.S. Population Aged 51–70 Years

et al. 2020

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Nationally representative data from the National Health and Nutrition Examination Survey (NHANES) indicate that over 65% of adults aged 51–70 years in the U.S. do not meet hydration criteria. They have hyponatremia (serum sodium < 135 mmol/L) and/or underhydration (serum sodium >145 mmol/L, spot urine volume <50 mL, and/or spot urine osmolality ≥500 mmol/kg). To explore potential public health implications of not meeting hydration criteria, data from the NHANES 2009–2012 and National Center for Health Statistics Linked Mortality Files for fasting adults aged 51–70 years (sample n = 1200) were used to determine if hyponatremia and/or underhydration were cross-sectionally associated with chronic health conditions and/or longitudinally associated with chronic disease mortality. Underhydration accounted for 97% of the population group not meeting hydration criteria. In weighted multivariable adjusted Poisson models, underhydration was significantly associated with increased prevalence of obesity, high waist circumference, insulin resistance, diabetes, low HDL, hypertension, and metabolic syndrome. Over 3–6 years of follow-up, 33 chronic disease deaths occurred in the sample, representing an estimated 1,084,144 deaths in the U.S. Alongside chronic health conditions, underhydration was a risk factor for an estimated 863,305 deaths. Independent of the chronic health conditions evaluated, underhydration was a risk factor for 128,107 deaths. In weighted multivariable Cox models, underhydration was associated with 4.21 times greater chronic disease mortality (95% CI: 1.29–13.78, p = 0.019). Zero chronic disease deaths were observed for people who met the hydration criteria and did not already have a chronic condition in 2009–2012. Further work should consider effects of underhydration on population health.

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Hyperosmolality, High Blood Pressure, and Decreased Estimated Glomerular Filtration Rate in US Adolescents, National Health and Nutrition Examination Survey 1999–2012

Cited by 3 publications

References 42 publications

The accuracy of serum osmolarity calculation in small children

The accuracy of serum osmolarity calculation in small children

Association of serum osmolality with all-cause and cardiovascular mortality in US adults: A prospective cohort study

Underhydration Is Associated with Obesity, Chronic Diseases, and Death Within 3 to 6 Years in the U.S. Population Aged 51–70 Years

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