Hyperoside Protects Human Umbilical Vein Endothelial Cells Against Anticardiolipin Antibody-Induced Injury by Activating Autophagy

Wei, Aiwu; Xiao, Huidongzi; Xu, Guangli; Yu, Xile; Guo, Jingjing; Jing, Zhuqing; Shi, Shanshan; Song, Yanli

doi:10.3389/fphar.2020.00762

Cited by 13 publications

(9 citation statements)

References 57 publications

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“…16 For example, Hyp suppresses inflammation effectively in mice with acute lung injury, 17 and Hyp protects human umbilical vein endothelial cells against aCL-induced damage by triggering autophagy. 18 In addition, the protective effects of Hyp against RPL have also been described, and Hyp is confirmed to attenuate pregnancy loss by activating autophagy and inhibiting inflammation in a rat model. 19 Also, it is reported that Hyp exerts an inhibitory effect on NLRP3 inflammasome activation in human and mouse macrophages.…”

Section: Introductionmentioning

confidence: 93%

Hyperoside exerts protective effects against anticardiolipin antibody-induced recurrent pregnancy loss in vivo and in vitro

Song

Shi

et al. 2023

Hum Exp Toxicol

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Background Women with antiphospholipid syndrome (APS) or antiphospholipid antibodies (aPLs) are at high risk for obstetric complications, including recurrent pregnancy loss (RPL). However, effective treatments for RPL are lacking. Objective This study aimed to reveal the function and underlying mechanism of hyperoside (Hyp) in RPL associated with antiphospholipid antibodies (aCLs). Methods The pregnant rats ( N = 24) were divided randomly into four groups: normal human-IgG (NH-IgG); aCL-pregnancy loss (aCL-PL); aCL-PL + Hyp (40 mg/kg/day); aCL-PL + low molecular weight heparin (LMWH, 525 μg/kg/day). HTR‐8 cells were treated with 80 μg/mL aCL to establish the cell models of miscarriage. Results In pregnant rats, aCL-IgG injection raised the abortion rate of embryos, while Hyp treatment inhibited the effects. Additionally, Hyp inhibited the platelet activation and uteroplacental insufficiency caused by aCL. In vivo and in vitro experiments further suggested that Hyp suppressed aCL-induced inflammation and apoptosis by downregulating NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome-related factors and decreasing apoptotic rates. After aCL administration, Hyp therapy downregulated the expression of purinergic ligand-gated ion channel 7 (P2X7), which is reported to induce cytokine release and apoptosis. Furthermore, we found that the treatment of 3′-O-(4-Benzoyl) benzoyl-ATP (BzATP, an agonist of the P2X7 receptor) reversed the inhibitory effects of Hyp on cell function. Conclusions Hyp exerts protective effects on aCL-induced pregnancy loss by preventing platelet activation-mediated P2X7/NLRP3 pathway. Therefore, Hyp may provide a feasible pharmaceutical strategy for the treatment of RPL.

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Section: Introductionmentioning

confidence: 93%

Hyperoside exerts protective effects against anticardiolipin antibody-induced recurrent pregnancy loss in vivo and in vitro

Song

Shi

et al. 2023

Hum Exp Toxicol

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“… 72 Researchers also found that hyperoside could help to against the vascular endothelial injury induced by anticardiolipin antibody in human umbilical vein endothelial cells (HUVECs) via activating mammalian target of rapamycin (mTOR)-mediated autophagy. 73 Hyperoside protected HUVECs against H 2 O 2 damage, at least partially, by activating the extra cellular signal-regulated protein kinase (ERK) signaling pathway. 74 Hyperoside suppressed vascular inflammatory processes induced by high glucose (HG) in HUVECs and in C57BL/6 mice.…”

Section: Pharmacologic Effectmentioning

confidence: 99%

Potential Implications of Hyperoside on Oxidative Stress-Induced Human Diseases: A Comprehensive Review

Wang,

Zhang,

Yuan

et al. 2023

JIR

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Hyperoside is a flavonol glycoside mainly found in plants of the genera Hypericum and Crataegus , and also detected in many plant species such as Abelmoschus manihot , Ribes nigrum , Rosa rugosa , Agrostis stolonifera , Apocynum venetum and Nelumbo nucifera . This compound exhibits a multitude of biological functions including anti-inflammatory, antidepressant, antioxidative, vascular protective effects and neuroprotective effects, etc. This review summarizes the quantification, original plant, chemical structure and property, structure–activity relationship, pharmacologic effect, pharmacokinetics, toxicity and clinical application of hyperoside, which will be significant for the exploitation for new drug and full utilization of this compound.

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“…When HUVECs were pretreated with hyperoside (10, 20, 50 mM) for 24 h, the secretion of proinflammatory cytokines, such as IL-1b and IL-8, and endothelial adhesion cytokines such as TF, ICAM1, and VCAM1, was significantly reduced. Mechanistically, hyperoside activated autophagy and suppressed the mTOR/S6K and TLR4/Myd88/NF-k B signalling transduction pathways [ 66 ].…”

Section: Antioxidant Treatment In Aps Patients: the State Of The Artmentioning

confidence: 99%

Oxidative Stress in the Pathogenesis of Antiphospholipid Syndrome: Implications for the Atherothrombotic Process

et al. 2021

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Atherothrombosis is a frequent complication of the clinical history of patients with antiphospholipid syndrome (APS). Both atherothrombosis and APS are characterized by increased oxidative stress. Oxidative modifications are implicated in the formation of antiphospholipid antibodies, which in turn may favour the oxidative imbalance by increasing the production of reactive oxidant species (ROS) or by a direct interaction with pro-oxidant/antioxidant enzymes. As a result of these processes, APS patients suffer from an oxidative imbalance that may contribute to the progression of the atherosclerotic process and to the onset of ischemic thrombotic complications. The aim of this review is to describe mechanisms implicated in the formation of ROS in APS patients and their involvement in the atherothrombotic process. We also provide an overview of potential therapeutic approaches to blunt oxidative stress and to prevent atherothrombotic complications in these patients.

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Hyperoside Protects Human Umbilical Vein Endothelial Cells Against Anticardiolipin Antibody-Induced Injury by Activating Autophagy

Cited by 13 publications

References 57 publications

Hyperoside exerts protective effects against anticardiolipin antibody-induced recurrent pregnancy loss in vivo and in vitro

Hyperoside exerts protective effects against anticardiolipin antibody-induced recurrent pregnancy loss in vivo and in vitro

Potential Implications of Hyperoside on Oxidative Stress-Induced Human Diseases: A Comprehensive Review

Oxidative Stress in the Pathogenesis of Antiphospholipid Syndrome: Implications for the Atherothrombotic Process

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