Hyperoside attenuates non-alcoholic fatty liver disease in rats via cholesterol metabolism and bile acid metabolism

Wang, Songsong; Sheng, Feiya; Zou, Liang; Xiao, Jianbo

doi:10.1016/j.jare.2021.06.001

Cited by 65 publications

(41 citation statements)

References 61 publications

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“…Although previous studies on the antisteatotic effects of Hyp are scarce, this compound has been reported to reduce hepatic fat accumulation in rodents fed a high-fat diet and alcohol and in diabetes-induced rats [ 39 , 60 , 61 , 74 , 75 , 76 ]. The antisteatotic activity of Hyp in high-fat diet-induced C57BL/6 mice and diabetes-induced rats occurred with liver weight loss and reduced hepatic lipid contents, such as TG, TC, and NEFA [ 60 , 74 ].…”

Section: Pharmacological Effects Of Hyperoside In Liver Diseasesmentioning

confidence: 99%

“…Regarding the underlying mechanisms attributed to the antisteatotic effects of Hyp, it exerted beneficial actions in (1) maintaining hepatic lipid and glucose homeostasis by activating peroxisome proliferator-activated receptor gamma (PPARγ), which lowers glucose levels and reverses lipotoxicity; (2) reducing oxidative stress; (3) synthesizing bile acids from cholesterol by activating key catalytic enzymes CYP7A1 and CYP27A1; (4) increasing the β-oxidation of free fatty acids by the activation of nuclear farnesoid X receptor (FXR) and transcription factor liver X receptor (LXR)α implicated in lipid oxidation; and (5) inhibiting de novo lipogenesis by modulating hepatic de novo lipogenesis markers acetyl-CoA carboxylase (ACC) and sterol regulatory element binding proteins (SREBP)1,2 in vivo and in vitro [ 39 , 61 , 74 , 75 , 76 ] ( Table 3 ).…”

Section: Pharmacological Effects Of Hyperoside In Liver Diseasesmentioning

confidence: 99%

“…The hepatic expression of several key inflammatory cytokines and chemokines, such as TNF-α, interleukin (IL)-1β, IL-6, nitric oxide (NO), inducible nitric oxide synthase (iNOS), cyclooxygenase (COX)2, C-C motif chemokine ligand (CCL)2, and CCL5, was downregulated by the administration of Hyp during the inflammatory pathogenesis induced by CCl 4 and a high-fat diet [ 34 , 38 , 53 , 60 , 76 ].…”

Section: Pharmacological Effects Of Hyperoside In Liver Diseasesmentioning

confidence: 99%

“…The neutralization of inflammatory markers by Hyp in hepatic tissue was accompanied by marked improvement in histological findings from abnormal conditions, including hepatic inflammatory cell infiltration and Kupffer cell hyperplasia [ 34 , 38 , 53 , 76 ]. Hyp obtained from Artemisia capillaris and Zanthoxylum bungeanum leaves displayed anti-inflammatory effects against CCl 4 and high-carbohydrate/high-fat diet and alloxan-induced inflammation via hepatic removal of oxidative stress, respectively [ 34 , 53 ].…”

Section: Pharmacological Effects Of Hyperoside In Liver Diseasesmentioning

confidence: 99%

“…In addition to targeting TGF-β, Hyp improved histological findings exhibiting a hepatic fibrotic area increased by different etiologies, such as CCl 4 , a high-fat diet, and heart failure in mice and rats [ 35 , 55 , 76 ]. In particular, Hyp ameliorated CCl 4 -induced liver fibrosis and heart failure-induced hepatic fibrosis, accompanied by hepatocellular antioxidant defenses [ 35 , 59 ].…”

Section: Pharmacological Effects Of Hyperoside In Liver Diseasesmentioning

confidence: 99%

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Hyperoside as a Potential Natural Product Targeting Oxidative Stress in Liver Diseases

Jang

2022

Antioxidants

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Hyperoside (Hyp), also known as quercetin-3-O-galactoside or 3-O-β-D-galactopyranosyl, is a well-known flavonol glycoside that is abundant in various fruits, vegetables, and medicinal plants. Hyp has been suggested to exhibit a wide range of biological actions, including cardiovascular, renal, neuroprotective, antifungal, antifibrotic, and anticancer effects. Accumulating evidence supports the pharmacological activities of Hyp in improving liver pathophysiology. Hence, the present literature review aims to summarize preclinical data suggesting the beneficial effects and underlying mechanisms of Hyp. In addition, our study focuses on hepatic antioxidant defense signaling to assess the underlying mechanisms of the biological actions of Hyp that are closely associated with liver diseases. Experimental findings from an up-to-date search showed that Hyp possesses hepatoprotective, antiviral, antisteatotic, anti-inflammatory, antifibrotic, and anticancer activities in cellular and animal models related to liver dysfunction by enhancing antioxidant responses. In particular, hepatocellular antioxidant defense via activation of erythroid-related nuclear factor 2 by Hyp chiefly explains how this compound acts as a therapeutic agent in liver diseases. Thus, this review emphasizes the therapeutic potential of Hyp as a strong antioxidative substance that plays a crucial role in the regulation of various liver disorders during their pathogenesis.

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Section: Pharmacological Effects Of Hyperoside In Liver Diseasesmentioning

confidence: 99%

Section: Pharmacological Effects Of Hyperoside In Liver Diseasesmentioning

confidence: 99%

Section: Pharmacological Effects Of Hyperoside In Liver Diseasesmentioning

confidence: 99%

Section: Pharmacological Effects Of Hyperoside In Liver Diseasesmentioning

confidence: 99%

Section: Pharmacological Effects Of Hyperoside In Liver Diseasesmentioning

confidence: 99%

See 3 more Smart Citations

Hyperoside as a Potential Natural Product Targeting Oxidative Stress in Liver Diseases

Jang

2022

Antioxidants

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Increase in bile acids after sleeve gastrectomy improves metabolism by activating GPBAR1 to increase cAMP in mice with nonalcoholic fatty liver disease

Li,

Xu,

Chai

et al. 2024

Immunity Inflam & Disease

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BackgroundBile acids (BAs) concentration can affect metabolic improvement caused by bariatric surgery and BA concentrations increase in patients after sleeve gastrectomy (SG). Here, how BAs after SG affect metabolism in nonalcoholic fatty liver disease (NAFLD) was studied.MethodsMice were given high‐fat diet (HFD) to induce NAFLD and received SG surgery. Hepatic and fecal BA concentrations in mice were detected by liquid chromatography‐tandem mass spectrometry method. BA‐related genes were detected by quantitative real‐time polymerase chain reaction. G protein BA receptor 1 (GPBAR1) expression was identified using western blot analysis. NAFLD mice after SG received GPBAR1 inhibitor Triamterene. The weight of mice and mice liver was detected. Mouse liver tissue was observed by hematoxylin–eosin and Oil Red O staining. Triglyceride (TG), nonesterified fatty acid (NEFA), and cyclic adenosine monophosphate (cAMP) levels in mouse liver tissue were analyzed by metabolic assay and enzyme‐linked immune sorbent assay.ResultsSG boosted increase in hepatic total/conjugated BAs and related genes and GPBAR1 expression, and attenuated increase in fecal total BAs/muricholic acid in HFD‐induced mice and increased fecal taurine‐BAs in HFD‐induced mice. Triamterene (72 mg/kg) reversed the inhibitory role of SG in HFD‐induced increase of body weight, lipid accumulation, inflammatory cell infiltration, and increase of hepatic weight and TG/NEFA content, and counteracted the positive role of SG in HFD‐induced increase of hepatic cAMP concentration in mice.ConclusionsBAs improve metabolism via activating GPBAR1 to increase cAMP in NAFLD mice after SG.

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Influence of thermal processing on the quality of hawthorn: Quality markers of heat‐processed hawthorn

Guo

Bai

Zhang

et al. 2022

J of Separation Science

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Hawthorn and its derived products are used worldwide as foods as well as complementary medicine. During the preparation of hawthorn, heating and thermal processing are frequently reported. The thermal processing will change the medicinal purposes and modify the efficacy of hawthorn. However, details including the chemical profile shifting and quality markers of heat-processed hawthorn have not been well understood. In this study, we analyzed the hawthorn samples processed at different temperatures and different times by ultraviolet visible absorption spectrum and liquid-mass spectrometry technologies combined with multivariate statistical analysis. It was revealed for the first time that thermal processing could greatly change the ultraviolet-visible absorption spectra and chemical profiles of hawthorn even with heat treatment at 130 • C for 10 min. And the ultraviolet visible absorption spectrum, especially the ratio value (R A500 nm/400 nm ), was a descriptive and qualitative indicator of heating degree for the thermal processing at the macroscopic level. Several components, such as hyperoside, chlorogenic acid, quercetin, and apigenin, decreased or increased in content during the processing, and they could be utilized as the chemical quality markers. The proposed quality markers for heat-processed hawthorn will be helpful for further optimizing the processing conditions of hawthorn. K E Y W O R D Schemical profiles, hawthorn, multivariate statistical analysis, quality markers, thermal processing INTRODUCTIONHawthorn, also called Shanzha in Chinese, is the fruit of Crataegus pinnatifida Bge. and is used widely as a Chi-

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Hyperoside attenuates non-alcoholic fatty liver disease in rats via cholesterol metabolism and bile acid metabolism

Abstract: Graphical abstract

Cited by 65 publications

References 61 publications

Hyperoside as a Potential Natural Product Targeting Oxidative Stress in Liver Diseases

Hyperoside as a Potential Natural Product Targeting Oxidative Stress in Liver Diseases

Increase in bile acids after sleeve gastrectomy improves metabolism by activating GPBAR1 to increase cAMP in mice with nonalcoholic fatty liver disease

Influence of thermal processing on the quality of hawthorn: Quality markers of heat‐processed hawthorn

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