2011
DOI: 10.1016/j.bbrc.2011.06.046
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Hyperoside attenuates hydrogen peroxide-induced L02 cell damage via MAPK-dependent Keap1–Nrf2–ARE signaling pathway

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Cited by 64 publications
(36 citation statements)
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“…40 Unlike in previous reports, the signaling proteins p38 and ERK were protective in our studies, consistent with findings implicating these MAPK pathways in Nrf2-dependent antioxidant production. 41,42 A paradigm has emerged in AKI research in which many growth factors (e.g., epidermal growth factor and IGF) are upregulated after injury and facilitate renal repair. Our studies indicate that TGF-b does not fit this paradigm, probably because its proapoptotic effects on epithelial cells outweigh any beneficial effects in the context of AKI.…”
Section: Discussionmentioning
confidence: 99%
“…40 Unlike in previous reports, the signaling proteins p38 and ERK were protective in our studies, consistent with findings implicating these MAPK pathways in Nrf2-dependent antioxidant production. 41,42 A paradigm has emerged in AKI research in which many growth factors (e.g., epidermal growth factor and IGF) are upregulated after injury and facilitate renal repair. Our studies indicate that TGF-b does not fit this paradigm, probably because its proapoptotic effects on epithelial cells outweigh any beneficial effects in the context of AKI.…”
Section: Discussionmentioning
confidence: 99%
“…Hyperoside is a flavonol glycoside with variety of biological activities, including antioxidant, anticancer, antihyperglycemic and anti-inflammatory functions (25)(26)(27). However, prior to the current study, hyperoside has demonstrated little antibacterial activity (20,28).…”
Section: Effect Of Hyperoside On P Aeruginosa Biofilm Formationmentioning
confidence: 91%
“…Hyperoside attenuates H2O2-induced L02 cell damage via MAPK (p38 and ERK)-dependent Keap/Nrf2/ARE signaling pathway (Xing et al, 2011). Thus, whether taraxerolstimulated cytoprotective effect is involved in MAPKdependent Keap/Nrf2/ARE signaling pathway remains elusive.…”
Section: Discussionmentioning
confidence: 99%