Hypermobility in children

Coles, William; Copeman, Annabel; Davies, Karen

doi:10.1016/j.paed.2017.12.001

Cited by 9 publications

(5 citation statements)

References 13 publications

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“…The growing interest taken lately in UCTD affecting children and adolescents is due to the following factors: wide prevalence (individual signs occur in 14-85%); polymorphism of clinical and morphological disorders; polyorganic and polysystemic nature of lesions; disease course progression; biochemistry and physiology involvement; high risk of developing associated (secondary) pathological conditions affecting inner organs and systems; lack of commonly accepted diagnostic criteria; difficulties in assessing the nature, number and specificity of symptoms; specific features of the clinical course; negative impact the syndrome has on the course, prognosis and treatment of various diseases. In case of UCTD, significantly affected are the organs and systems that feature a high content of collagen: the bone-and-joint system, the cardiovascular system, the respiratory system, the organs of vision, the dental system [23][24][25][26][27][28][29][30][31].…”

Section: Introductionmentioning

confidence: 99%

Biochemical and Immunohistochemical Studies of Matrix Metalloproteinases in Periodontal Disease Pathogenesis Affecting Children With Connective Tissue Dysplasia Syndrome

Domenyuk¹,

Gilmiyarova²,

Shkarin³

et al. 2023

ArveMED

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The interest taken in studying pathomorphological and pathophysiological mechanisms behind periodontal inflammation affecting children with undifferentiated connective tissue dysplasia (UCTD) can be accounted for by the disease high prevalence, risk of its progression, as well as morphological and functional immaturity of tissues and low effectiveness of the available treatment options. The study into the matrix metalloproteinases (MMPs) expression in the gum and oral fluid biopsy material in children with UCTD is of both scientific and practical value in terms of diagnostic identification, disease course assessment, and the design of individualized treatment modes for periodontal diseases. In order to determine the specific features of MMP-2, MMP-8, MMP-9 expression, our study involved 61 children with periodontal diseases and various degrees of UCTD, as well as 27 healthy children with intact periodontium. The study implied analyzing the participants’ immune-histochemical studies of gum biopsy material and oral fluid enzyme immunoassay results. The enzyme immunoassay of MMP concentration in the oral fluid revealed that children with a prominent degree of UCTD, had their MMP-2, MMP-8, MMP-9 expression (medians 5.49 ng/ml, 478.4 ng/ml, 921.6 ng/ml, respectively) exceeding significantly the concentration of these enzymes in children whose degree of UCTD could be described as mild (medians 2.76 ng/ml, 317.1 ng/ml, 584.3 ng/ml, respectively). An analysis of the MMP expression in the gum biopsy material showed that MMP-2 is not a reliable indicator to offer data required to assess the clinical status of periodontal tissues, since it is detected both in healthy children with intact periodontium and in children with periodontal disease and the UCTD syndrome. MMP-8 and MMP-9 can provide an objective description of the active phase of periodontium inflammation, which means these enzymes should be considered as reliable biomarkers of inflammation activity at the disease manifestation stage. Biochemical and immunohistochemical studies of MMP-2, MMP-8, MMP-9 the expression in oral fluid and gum biopsy material in children with UCTD syndrome should be used to identify the periodontium structural and functional status, the nature of inflammation, to detect potential risk groups vulnerable to the development of periodontal diseases, as well as to evaluate the effectiveness of various schemes for comprehensive treatment of periodontal issues.

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Section: Introductionmentioning

confidence: 99%

Biochemical and Immunohistochemical Studies of Matrix Metalloproteinases in Periodontal Disease Pathogenesis Affecting Children With Connective Tissue Dysplasia Syndrome

Domenyuk¹,

Gilmiyarova²,

Shkarin³

et al. 2023

ArveMED

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“…The level of dental health is an overall health status indicator for the entire body, so a high incidence of dental issues (25.2%-84.3%) in childhood points at the need for an in-depth study of the etiopathogenesis of orthodontic nosological forms, which, in turn, is to help develop effective diagnostic algorithms and optimal tactics to treat occlusion disorders [14,18,22,26,30,36,46]. The connective tissue system, which is decisive for the functional and morphological integrity of the body, has a role in the development of most maxillofacial structures, while children with dysplastic disorders feature a high prevalence of dental anomalies, carious and non-carious lesion of teeth, periodontium and temporomandibular joint [1,3,5,44].…”

Section: Introductionmentioning

confidence: 99%

Periodontal Tissue Morphology in Children With Abnormal Occlusion and Connective Tissue Dysplasia Syndrome

Domenyuk¹,

Kochkonyan²,

Дмитриенко³

et al. 2022

ArveMED

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The study involved an analysis of the data gum biopsies obtained through light microscopy and polarization microscopy in order to identify pathomorphological features and the collagen Type I & Type III ratio in 56 children with occlusion issues, periodontal diseases and various undifferentiated connective tissue dysplasia (UCTD). 32 healthy children with intact periodontium served as a control group. For the histological examination of gum biopsies, the respective sections were stained with hematoxylin and eosin, while Picro-Sirius Red Stain Kit reagents were used to assess the Type I and Type III collagen distribution in the gum connective tissue. The image processing was performed in the ImageJ 1.47 software, while when analyzing the color histograms, the ratio of the red pixels (Type I collagen) and the green pixels (Type III collagen) was identified. The Type I/III collagen ratio (1.41±0.09) in children with chronic catarrhal gingivitis, occlusion issues and a “prominent” degree of UCTD was found to be significantly lower (p≤0.05) the similar ratio observed in patients with clinically healthy periodontium (2.01±0.09), as well as in patients with “mild” and “moderate” UCTD (1.63 ± 0.17) with homogeneous clinical and morphological dental manifestations. The effectiveness of the developed comprehensive dental treatment program for periodontal issues in children with abnormal occlusion associated with UCTD, including conservative anti-inflammatory treatment, pharmacological correction and orthodontic treatment, is justified by an increase in the amount of mature Type I collagen, a decrease in the developing immature Type III collagen, and inflammation in the periodontal tissues. A sufficient degree of maturity and differentiation of connective tissue was also achieved.

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“…CTD clinical manifestations depend on the predominance of lesions in the dense or loose connective tissue, the number and quality of mutations, the nature and severity of fibrillogenesis disturbance. Due to the common presence of connective tissue (skin, bones, cartilage, vascular walls, organs stroma), the disease features a polysystemic nature and a variety of symptoms [3,6,8,27].…”

Section: Introductionmentioning

confidence: 99%

Morphology of Facialskeleton in Childrenwith Undifferentiated Connectivetissue Dyspl

Avanisyan¹,

Al-Harazi²,

Kondratyeva³

et al. 2020

AREM

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In order to determine the major cephalometric and gnathometric features in children with undifferentiated connective tissue dysplasia, a comprehensive clinical-instrumental and X-ray examination was carried out involving 109 children aged 11-16 and featuring a set of signs pointing at connective tissue failure. Depending on the severity of the external phenotypic manifestations as well as clinical and instrumental signs, the patients were divided into groups with mild, moderate and severe undifferentiated dysplasia. The gnathometric and biometric maxillofacial studies were performed employing traditional methods, while the diagnosis was set following the generally accepted classifications. The head telerentgenograms (lateral projection) interpretation was performed in the Dolphin imaging software. The analysis of the head telerentgenograms (lateral projection) was done through the Schwartz S. method subject to the norm indicators proposed by A.A. Anikienko. The nature and the intensity of morphofunctional issues in the craniofacial structures (small stigmas) were found to be determined by the severity of dysplastic connective tissue disorders. Constitutional and morphological dysgenesia, as a manifestation of connective tissue dysplasia, is the reason behind abnormal development in the anatomical structure of the cranial and facial regions. It is displayed through increasing dolichocephaly with a decrease in the face width and vertical size, poorly developed jaws, distal displacement of the mandible in relation to the skull base combined with a deep incisal overbite, increased sagittal interincisal distance, and the vertical type of jaw growth. Thus, the pathogenetic mechanisms facilitate the development of malocclusions. K E y w o r d s -children, adolescents, undifferentiated connective tissue dysplasia, facial skeleton, cephalometry, gnathometry, maxillofacial region, lateral projection of head telerentgenogram.

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Hypermobility in children

Cited by 9 publications

References 13 publications

Biochemical and Immunohistochemical Studies of Matrix Metalloproteinases in Periodontal Disease Pathogenesis Affecting Children With Connective Tissue Dysplasia Syndrome

Biochemical and Immunohistochemical Studies of Matrix Metalloproteinases in Periodontal Disease Pathogenesis Affecting Children With Connective Tissue Dysplasia Syndrome

Periodontal Tissue Morphology in Children With Abnormal Occlusion and Connective Tissue Dysplasia Syndrome

Morphology of Facialskeleton in Childrenwith Undifferentiated Connectivetissue Dyspl

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