2018
DOI: 10.1186/s13046-018-0958-1
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Hypermethylation of DMTN promotes the metastasis of colorectal cancer cells by regulating the actin cytoskeleton through Rac1 signaling activation

Abstract: BackgroundColorectal cancer (CRC) is one of the most common digestive malignant tumors, and DMTN is a transcriptionally differentially expressed gene that was identified using CRC mRNA sequencing data from The Cancer Genome Atlas (TCGA). Our preliminary work suggested that the expression of DMTN was downregulated in CRC, and the Rac1 signaling pathway was significantly enriched in CRC tissues with low DMTN expression. However, the specific functions and underlying molecular mechanisms of DMTN in the progressio… Show more

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Cited by 30 publications
(20 citation statements)
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“…It also plays a key role in cell migration. Large concentrations of Rac can be found around migrating cells, which can regulate the aggregation of microfilaments into pseudopodia and promote cell migration 22,30 .…”
Section: Discussionmentioning
confidence: 99%
“…It also plays a key role in cell migration. Large concentrations of Rac can be found around migrating cells, which can regulate the aggregation of microfilaments into pseudopodia and promote cell migration 22,30 .…”
Section: Discussionmentioning
confidence: 99%
“…Moreover, DNA methylation was also an important mechanism regulating gene mRNA expression ( 26 ). Thus, we analyzed the relationship between IFI44 methylation and mRNA transcription sites.…”
Section: Resultsmentioning
confidence: 99%
“…Xenograft tumors were generated by subcutaneous injection of cells (2 × 10 6 for SW480/Lv105 and SW480/Siah1) on the hind limbs of 4-6 weeks old Balb/C athymic nude mice (nu/nu; the Animal Center of Southern Medical University, Guangzhou, China n = 6 for each group). Subsequent treatment of all mice was performed as previously described [35]. We counted five randomly selected high-power fields and calculated the average percentage of stained cells among the total cell as the Ki-67 (Bioworld, #bs1454, dilutions: 1:200) index in subsequent IHC staining [36].…”
Section: Tumorigenesis In Nude Micementioning
confidence: 99%