Hyperlipidemia in association with pro-inflammatory cytokines among chronic spon-taneous urticaria: case-control study

Abstract

Chronic spontaneous urticaria (CSU) is a disorder characterized by recurrent transient itchy wheels of 6 weeks duration or longer. The cause cannot be pinpointed in about 40% of patients. To elucidate the possible association between CSU and hyperlipidemia, 40 CSU patients and 40 group matched healthy individuals were assessed for hyperlipidemia. Data on history, urticaria activity score (UAS-7), physical examination and routine laboratory investigations including (serum IL6 and TNF α) were recorded. Statistically significant increase of serum cholesterol, triglycerides (TG), low density lipoprotein (LDL), IL6, TNFα and decrease of high density lipoprotein (HDL) was found in CSU in comparison to control group. Regarding the different disease variables, both TG and cholesterol were positively correlated with duration of illness, urticaria score and TNF α. Serum LDL detected significant had a positive correlation with duration of illness, urticaria score, CRP and TNF α, while serum HDL detected had a significant negative correlation with TNF α. IL6 and TNFα associated systemic inflammation could be a common pathogenic mechanism of CSU and hyperlipidemia. Patients with CSU should be evaluated for hyperlipidemia.

Intersecting pathways: evaluating inflammatory markers and metabolism in chronic spontaneous urticaria with a multi‐marker approach

“…37 Amin et al demonstrated that CSU patients had reduced HDL levels and suggested that a common pathogenic mechanism linking CSU and hyperlipidemia might entail systemic inflammation associated with IL6 and TNF-a. 38 In our study, increased UHR value (P = 0.041) and decreased uric acid (P = 0.005) and HDL values (P < 0.001) were found to be significant in the differentiation of CSU (Table 1). In the patient group, the univariate logistic regression analysis revealed that UHR did not exhibit substantial efficacy (P = 0.085), while HDL was significant (P < 0.001) with the highest accuracy value (69.4%; Table 2).…”

Association of serum biochemical indexes and thyroid nodule with disease activity in patients with chronic spontaneous urticaria

“…Maged et al also found that TG, IL-6 and TNF-α were higher in the patient group than in the control group, and that TG was positively correlated with TNF-α, indicating that hyperlipidemia promotes inflammation. 11 In addition, some inflammatory factors such as TNF-α can inhibit insulin receptor tyrosine enzyme activity, interfere with insulin signal transduction and cause insulin resistance, fat mobilisation, the production of large amounts of free fatty acid, increased TG synthesis and insulin resistance in liver cells. They can also increase apolipoprotein C synthesis and inhibit lipoprotein lipase lipolysis of TG, ultimately resulting in higher TG.…”

Dietary habits in Japanese patients with chronic spontaneous urticaria

“…Although there is no evidence that egg consumption promotes the development of CSU. eggs contain high concentrations of cholesterol, which may contribute to dyslipidemia, a comorbidity of CSU 8 and relevant to coagulation pathway and inflammation 23,24 . Oxidised LDL may induce mast cells to release histamine 24 …”

“…It has recently been reported that CSU patients have increased risk of obesity or metabolic syndromes, 2,7 particularly dyslipidemia 8 . Serum cholesterol or low‐density lipoprotein (LDL) levels in CSU patients are increased and correlated with disease severity 8 .…”