Hyperlipasemia in Pediatric Inflammatory Bowel Diseases

Ihekweazu, Faith D.; Nagy-Szakal, Dorottya; Fishman, Douglas S.; Kellermayer, Richárd

doi:10.1097/mpa.0000000000000513

Cited by 1 publication

(1 citation statement)

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“…Заподозрить этот синдром можно на основании отягощенного семейного анамнеза ХБПГ, приема лекарственных препаратов (парацетамол, стероиды, эфедрин, химиотерапия). Несмотря на чрезвычайно редкую распространенность изолированной гиперлипаземии, в литературе есть сообщения о доброкачественном течении этой биохимической аномалии у детей [35], взрослых [48,56], при воспалительных заболеваниях кишечника [27]. Однако спустя некоторое время после первого описания гиперлипаземии в рамках синдрома Гулло были отмечены случаи макролипаземии: исследователи зафиксировали способность липазы образовывать крупные молекулярные комплексы с иммуноглобулинами А, G [58].…”

Section: гиперлипаземия и макролипаземияunclassified

Secrets, puzzles and mysteries of macroamylasemia

Губергріц

Byelyayeva

Лукашевич

et al. 2020

Bul. of the Club of Pancr.

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Physiological features of amylase synthesis and excretion are considered in the article, presence of other sources of amylase synthesis different from pancreas and salivary glands is emphasized. Definitions of hyperenzymemia and macroamylasemia (MAE) are given. MAE is a state characterized by presence of circulating complexes of normal serum amylase with protein or carbohydrates in blood. There are 3 types of MAE: first — classical (constant hyperamylasemia, decreased amylase level in urine, high blood concentration of macroamylase complexes); second — hyperamylasemia with slightly decreased amylase activity in urine, macroamylase/normal amylase ratio is less than in the first type; third — normal blood and urine amylase activity, low macroamylase/normal amylase ratio. Pathogenesis is explained by connection of blood amylase and acute phase protein in different inflammatory, infectious diseases, malabsorption. MAE clinical manifestations could be absent, sometimes abdominal pain is possible. Hyperamylasemia and reduced urine amylase activity are typical. MAE diagnostics means determination of macroamylase complexes in blood (chromatography, calculation of the clearance ratio of amylase and creatinine). The article presents clinical cases describing extra-pancreatic MAE in women with malignant ovarian lesions. The question of expediency of thorough diagnostic examination in asymptomatic MAE is raised, which may turn out to be a symptom of cancer. The lack of specific treatment for MAE is emphasized.

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