Hyperlipämie und latenter Diabetes mellitus

Braunsteiner, H; Pauli, Raimund Di; Sailer, S; Sandhofer, F

doi:10.1007/bf01707067

Cited by 13 publications

(2 citation statements)

References 7 publications

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“…Effect of Powdered Cuminum nigrum Seeds, theirAqueous and hyperglycaemic states e. g. in patients suffering from diabetes mellitus. Braunsteiner et al (10) have reported that, in latent Methanol Extracts and of Tolbutamide on Blood Total Lipid diabetes with hypertriglyceridaemia, the plasma-free fatty Levels in Normal Rabbits acids are also increased. Thus, blood total lipid contents were Mean blood total lipids SEM of the control rabbits at zero also estimated in normal and alloxan-diabetic rabbits after oral hour after administration of water were 504 25 mg/100 ml and administration of various doses of C. nigrum seeds as well as were not significantly (P> 0.05) affected at 4, 10 and 24 hours.…”

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Study of Hypoglycaemic Activity ofCuminum nigrumSeeds in Normal and Alloxan Diabetic Rabbits

Ms¹,

Mr²

1985

Planta Med

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Blood glucose and total lipid levels of normal and alloxantreated diabetic rabbits were determined after oral administration of various doses of the Cuminum nigrum L. seeds and their extracts in water and methanol. From the data obtained, it is concluded that the oral administration of 1,2, 3 and 4 g/kg of C. nigrum seeds produces a significant hypoglycaemic effect in normal as well as in diabetic rabbits. The water and methanol extracts also decreased the blood glucose level in normal and alloxan-diabetic rabbits. However, the total blood lipids were not influenced by this substance in either normal or diabetic rabbits. The acute toxicity studies carried out on rabbits could not reveal any adverse or side effects of this folk medicine at the dosages tested. It is suggested that the C. nigrum seeds contain one or more hypoglycaemic principles which can significantly reduce the blood glucose but not total lipids level in normal rabbits and in those with alloxan-induced diabetes.

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Study of Hypoglycaemic Activity ofCuminum nigrumSeeds in Normal and Alloxan Diabetic Rabbits

Ms¹,

Mr²

1985

Planta Med

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“…Prenylamine differs in its effects from either of the two classes of blocking agents used in that it is reported to produce a reserpine-like depletion of catecholamine storage granules (Schone & Lindner, 1960;Carlsson, Hillarp & Waldeck, 1963), and was shown to exhibit both a-adrenolytic (Kochsiek, Scheler & Bretschneider, 1960;Lindner, 1963;Kuschke, Eckmann & others, 1964;Obianwu, 1967) and P-adrenolytic (Lindner, 1960(Lindner, , 1964Haas, 1964 ;Fleckenstein, Doring & others, 1968) properties. Lindner (1964) and Braunsteiner, Sailer & Sandhofer (1965) showed prenylamine to block the noradrenaline-induced mobilization of free fatty acids in dogs, and to lower free fatty acid blood levels in man. The slight elevation of cholesterol seen in our experiments after prenylamine, 25 and 50 mg/kg, as well as the failure of 25 mg/kg to block the hypercholesterolemic effect of adrenaline may reflect the sympathomimetic properties of prenylamine in discharging endogenous catecholamines.…”

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confidence: 99%