Hyperintensity in the Dentate Nucleus on Nonenhanced T1-Weighted Magnetic Resonance Imaging Suggests Dechelation of Contrast Agents

Jessome, Rebecca

doi:10.1016/j.jmir.2015.10.005

Cited by 3 publications

(3 citation statements)

References 14 publications

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“…For interested readers a bibliography of articles on this topic is maintained by the correspondent online [ En qualit e de chercheur int eress e par ce domaine, j'appr ecie la publication de l'article de Jessome [1]. Il fournit un contexte aux observations r ecentes sur l'accumulation de gadolinium dans les tissus c er ebraux a la suite de l'utilisation conforme r ep et ee de certains agents de contraste a base de gadolinium pour l'IRM.…”

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Letter to the Editor

Brown

2016

Journal of Medical Imaging and Radiation Sciences

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As an interested researcher in this field, I welcome the publication of the article by Jessome [1]. It provides some background to the recent observations of gadolinium accumulation in brain tissues following repeated on-label use of particular gadolinium-based contrast agents (GBCA) for magnetic resonance imaging. The article outlines the key chemical issues of the deposition and, importantly, stresses that no GBCA is completely resistant to the chemical dissociation and that the stability of the gadolinium to chelate bond varies substantially across the molecular structures used in commercial GBCA. It also highlights that the body has no way to naturally rid itself of gadolinium dissociated from the chelate ligand and that the liberated gadolinium ion (Gd 3þ) will form new compounds in vivo with biochemically toxic impacts. No potential conflict of interest relevant to this letter was reported. The JMIRS invited replies from the authors of the original publication.

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Letter to the Editor

Brown

2016

Journal of Medical Imaging and Radiation Sciences

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“…Safety of the gadolinium-based contrast agents for magnetic resonance imaging, focusing in part on their accumulation in the brain and especially the dentate nucleus. Invest Radiol 51 5 En qualit e de chercheur int eress e par ce domaine, j'appr ecie la publication de l'article de Jessome [1]. Il fournit un contexte aux observations r ecentes sur l'accumulation de gadolinium dans les tissus c er ebraux a la suite de l'utilisation conforme r ep et ee de certains agents de contraste a base de gadolinium pour l'IRM.…”

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“…La macromol ecule de ch elate de gadolinium traversait-elle la barri ere h emato-enc ephalique, ou le Gd etait-il dans une forme diff erente, indiquant une dissociation de la macromol ecule?Depuis, de nombreuses publications abordent les hypotheses changeantes pr esent ees par l'examen de Jessome. L'incidence de la stabilit e cin etique des agents de contraste a base de gadolinium d eterminant du d epôt de gadolinium a et e appuy ee par des etudes contrôl ees sur des animaux de Roberts et al[8], qui a observ e que l'exposition au gadodiamide1 Gd-DTPA, gadopent etate de dim eglumine -Magnevist-Bayer/Berlex.…”

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