Hyperintensities of middle frontal gyrus in patients with diabetic optic neuropathy: a dynamic amplitude of low-frequency fluctuation study

Abstract

Diabetic optic neuropathy (DON) is a diverse complication of diabetes and its pathogenesis has not been fully elucidated. The purpose of this study was to explore dynamic cerebral activity changes in DON patients using dynamic amplitude of low-frequency fluctuation (dALFF). In total, 22 DON patients and 22 healthy controls were enrolled. The dALFF approach was used in all participants to investigate dynamic intrinsic brain activity differences between the two groups. Compared with HCs, DON patients exhibited significantly increased dALFF variability in the right middle frontal gyrus (P < 0.01). Conversely, DON patients exhibited obviously decreased dALFF variability in the right precuneus (P < 0.01). We also found that there were significant negative correlations between HADS scores and dALFF values of the right middle frontal gyrus in the DON patients (r = -0.6404, P <0.01 for anxiety and r = -0.6346, P <0.01 for depression; HADS, Hospital Anxiety and Depression Scale). Abnormal variability of dALFF was observed in specific areas of the cerebrum in DON patients, which may contribute to distinguishing patients with DON from HCs and a better understanding of DON, hyperintensities of right middle frontal gyrus may be potential diagnostic marker for DON.

Amplitude of Low-Frequency Fluctuation to Determine Disturbed Spontaneous Brain-Activity Pattern in Patients with Diabetic Optic Neuropathy

“… 41 Our findings are in accordance with all the above ophthalmology-related diseases. However, our results are partially disparate from several articles on the same topic, 24 , 42 mainly because the sample sizes in theses three articles were both relatively small, and the technologies used were different, which may cause the difference. The medial frontal gyrus and orbital gyri both belong to the prefrontal cortex, which covers the anterior part of the frontal lobe and participates in various critical cognitive and emotional processing tasks.…”

Association between gene expression and altered resting-state functional networks in type 2 diabetes

“…Retinopathy is a common diabetes complication, which can lead to visual impairment. Most studies on T2DM patients with optic nerve-related complications have reported negative alterations in the MOG and the precuneus, including decreased synchronous neural activities, decreased dynamic cerebral activity ( Yang et al, 2022 ), lower degree centrality ( Huang et al, 2021 ), and decreased connectivity ( Zhang et al, 2020 ; Wan et al, 2021 ). When extended to a wider population of diabetes, the results are inconsistent.…”