1988
DOI: 10.1016/0026-0495(88)90133-3
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Hyperinsulinemia, upper body adiposity, and cardiovascular risk factors in non-diabetics

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Cited by 255 publications
(98 citation statements)
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“…3 Almost the same concept was advocated by Kaplan as`Deadly Quartet', which was a combination of glucose intolerance, hypertriglyceridemia, hypertension and obesity. 4 In further studies, visceral adiposity or intra-abdominal fat accumulation was shown to be much more related to a group of atherogenic disorders, hyperinsulinemia, 18,19 hypertension, 20 hyperlipidemia, 21 and cardiovascular disease itself, 22,23 rather than obesity per se. On the basis of these data, Matsuzawa et al proposed that a common pathology of the clustering of those risk factors for atherosclerosis might be intraabdominal fat deposition.…”
Section: Discussionmentioning
confidence: 94%
“…3 Almost the same concept was advocated by Kaplan as`Deadly Quartet', which was a combination of glucose intolerance, hypertriglyceridemia, hypertension and obesity. 4 In further studies, visceral adiposity or intra-abdominal fat accumulation was shown to be much more related to a group of atherogenic disorders, hyperinsulinemia, 18,19 hypertension, 20 hyperlipidemia, 21 and cardiovascular disease itself, 22,23 rather than obesity per se. On the basis of these data, Matsuzawa et al proposed that a common pathology of the clustering of those risk factors for atherosclerosis might be intraabdominal fat deposition.…”
Section: Discussionmentioning
confidence: 94%
“…The comparatively higher diastolic BP demonstrated in our Asian-Indian subjects is in accordance with previous reports, which showed that insulin resistance is often accompanied by other coronary risk factors. 26,27 When comparing their metabolic characteristics, Asian Indians had the highest fasting insulin and triglyceride. These observations again were consistent with previous findings that Asian Indians have increased prevalence of the components of the insulin resistance syndrome.…”
Section: Resultsmentioning
confidence: 99%
“…In our later survey (1984)(1985)(1986)(1987)(1988), both fasting and 2-hour insulin concentrations were measured, and the latter were more strongly correlated with blood pressure than the former, at least cross sectionalh/. 16 Follow-up of the 1984-1988 cohort, however, has not yet been completed. On the other hand, we were able to document a strong relation between fasting insulin and future diabetes, 4 * indicating that the weaker relation reported here is probably not due to insensitivity of our assay for fasting insulin.…”
Section: Discussionmentioning
confidence: 97%