Hyperinsulinemia, upper body adiposity, and cardiovascular risk factors in non-diabetics

Haffner, Steven M.; Fong, Donald S.; Hazuda, Helen P.; Pugh, Jacqueline A.; Patterson, Judith K.

doi:10.1016/0026-0495(88)90133-3

Cited by 255 publications

(98 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…3 Almost the same concept was advocated by Kaplan as`Deadly Quartet', which was a combination of glucose intolerance, hypertriglyceridemia, hypertension and obesity. 4 In further studies, visceral adiposity or intra-abdominal fat accumulation was shown to be much more related to a group of atherogenic disorders, hyperinsulinemia, 18,19 hypertension, 20 hyperlipidemia, 21 and cardiovascular disease itself, 22,23 rather than obesity per se. On the basis of these data, Matsuzawa et al proposed that a common pathology of the clustering of those risk factors for atherosclerosis might be intraabdominal fat deposition.…”

Section: Discussionmentioning

confidence: 94%

Preperitoneal fat thickness determined by ultrasonography is correlated with coronary stenosis and lipid disorders in non-obese male subjects

et al. 2000

View full text Add to dashboard Cite

OBJECTIVE: To investigate the relationship between preperitoneal fat thickness (PFT) determined by ultrasonography and the risk of coronary arterial disease, 130 non-obese patients with ischemic heart disease (77 men and 53 women) were examined. RESULTS: There was a positive correlation between PFT and coronary artery stenosis score (r 0.212, P`0.05). After dividing the patients by gender, the correlation was recognized only in men (r 0.246, P`0.05). Also, PFT was positively correlated to serum total cholesterol (r 0.259, P`0.01), triglyceride (r 0.205, P`0.05) and low density lipoprotein (LDL)-cholesterol (r 0.205, P`0.05), and negatively correlated to serum high density lipoprotein (HDL)-cholesterol (r 7 0.261, P`0.01). Again, these correlations were found only in men, not in women. CONCLUSION: PFT shows good correlations with coronary artery stenosis score and dislipidemia, and may lead to the development of coronary artery disease in non-obese male subjects.

show abstract

Section: Discussionmentioning

confidence: 94%

Preperitoneal fat thickness determined by ultrasonography is correlated with coronary stenosis and lipid disorders in non-obese male subjects

et al. 2000

View full text Add to dashboard Cite

show abstract

“…The comparatively higher diastolic BP demonstrated in our Asian-Indian subjects is in accordance with previous reports, which showed that insulin resistance is often accompanied by other coronary risk factors. 26,27 When comparing their metabolic characteristics, Asian Indians had the highest fasting insulin and triglyceride. These observations again were consistent with previous findings that Asian Indians have increased prevalence of the components of the insulin resistance syndrome.…”

Section: Resultsmentioning

confidence: 99%

Lean, nondiabetic Asian Indians have decreased insulin sensitivity and insulin clearance, and raised leptin compared to Caucasians and Chinese subjects

et al. 2003

Int J Obes

View full text Add to dashboard Cite

OBJECTIVE:To study and compare the insulin sensitivity of healthy, nondiabetic Asian Indians with that of two other ethnic groups (Caucasian and Chinese) living in Singapore. DESIGN: Study of insulin sensitivity using euglycaemic hyperinsulinaemic glucose clamp. SUBJECTS: A total of 10 healthy, lean, young male subjects of each ethnic group, matched for age, body mass index (BMI) and physical activity. They all had normal glucose tolerance and had no family history of diabetes. MEASUREMENTS: Anthropometric parameters (BMI, waist-hip ratio (WHR) and percentage body fat (PBF)), fasting lipid profile and leptin concentration, insulin sensitivity index, and insulin clearance. , diastolic blood pressure (P ¼ 0.036), fasting insulin (Po0.006) and fasting triglyceride (P ¼ 0.022). Stepwise regression analysis showed that ethnicity was the only significant independent determinant variable for the differences in insulin sensitivity index (P ¼ 0.008). CONCLUSION: Healthy lean nondiabetic Indians were more insulin resistant compared to other ethnic groups despite the similarity in living environment. These findings may warrant preventive health-care strategies for type II diabetes and coronary artery disease to target Indians at an earlier stage compared to other ethnic groups.

show abstract

“…In our later survey (1984)(1985)(1986)(1987)(1988), both fasting and 2-hour insulin concentrations were measured, and the latter were more strongly correlated with blood pressure than the former, at least cross sectionalh/. 16 Follow-up of the 1984-1988 cohort, however, has not yet been completed. On the other hand, we were able to document a strong relation between fasting insulin and future diabetes, 4 * indicating that the weaker relation reported here is probably not due to insensitivity of our assay for fasting insulin.…”

Section: Discussionmentioning

confidence: 97%

Clustering of cardiovascular risk factors in confirmed prehypertensive individuals.

et al. 1992

View full text Add to dashboard Cite

Numerous studies have indicated that hypertensive subjects have an atherogenic lipoprotein pattern, hyperinsulinemia, and impaired glucose tolerance relative to normotensive individuals. These abnormalities could be due to adverse effects of certain antihypertensive agents, to pathophyslological concomitants of the hypertensive state itself, or to both. In this report, we describe the cardiovascular risk factor profile of 1,440 subjects who were normotensive and were not taking any antihypertensive medications when first examined and who subsequently participated in the 8-year follow-up of the San Antonio Heart Study. Hypertension developed in 130 subjects during the follow-up period. At baseline these prehypertensive individuals had significantly higher levels of blood pressure, fasting total and low density lipoprotein cholesterol, triglyceride, glucose, and insulin, and 2-hour glucose than those who remained free of hypertension. In addition, they had higher body mass indexes, a less favorable body fat distribution, and lower levels of high density lipoprotein cholesterol. In multiple linear regression analyses, baseline levels of triglyceride and blood pressure remained significantly higher and high density lipoprotein cholesterol remained significantly lower in the subjects who later converted to hypertension than in those who remained normotensive. Although baseline insulin levels were also higher in the prehypertensive subjects, this difference was not statistically significant In nonobese subjects, however, those with high baseline insulin concentrations had nn increased incidence of hypertension compared with those with low insulin concentrations. The present results suggest that the cluster of atherogenic changes associated with hypertension actually precede the development of the hypertensive state. adiposity, alcohol consumption, and glucose intolerance are all related to the incidence of hypertension.1 " 7 Dietary minerals such as increased sodium and decreased potassium intake have also been implicated in the etiology of hypertension.8 " 11 Little is known, however, about possible metabolic precursors of hypertension, especially dyslipidemia and hyperinsulinemia. Previous epidemiologica] studies that report clustering of cardiovascular risk factors in patients with hypertension are limited because, in general, they have been cross-sectional. 12 -16 It is possible, therefore, that this clustering of risk factors could result from compensatory mechanisms that induce secondary metabolic changes (e.g., increased catecholamine concentrations secondary to the hypertensive state). Alternatively, certain antihypertensive agents have been reported to induce dyslipidemia and to increase insulin resistance. 17In metabolic ward studies, insulin resistance as mea- Supported by grants R01 HL-24799 and R37 HL-36820 from the National Heart, Lung, and Blood Institute.Address The significance of the clustering of cardiovascular risk factors in hypertensive patients can be clarified to a considerable degree by exami...

show abstract

Hyperinsulinemia, upper body adiposity, and cardiovascular risk factors in non-diabetics

Cited by 255 publications

References 50 publications

Preperitoneal fat thickness determined by ultrasonography is correlated with coronary stenosis and lipid disorders in non-obese male subjects

Preperitoneal fat thickness determined by ultrasonography is correlated with coronary stenosis and lipid disorders in non-obese male subjects

Lean, nondiabetic Asian Indians have decreased insulin sensitivity and insulin clearance, and raised leptin compared to Caucasians and Chinese subjects

Clustering of cardiovascular risk factors in confirmed prehypertensive individuals.

Contact Info

Product

Resources

About