Hyperinsulinemia does not Acutely Enhance Adrenal Androgen Production in Women or Men

Kd, Helm; McCartney, CR; Ql, Okonkwo; Blank, SK; Ej, Barrett; Jc, Marshall

doi:10.1055/s-2007-984479

Cited by 2 publications

(1 citation statement)

References 15 publications

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“…Recent human studies on the effect of hyperinsulinemia on AA production and metabolism have demonstrated divergent results (33)(34)(35)(36). These results may be due to the variability of the populations studied.…”

Section: Discussionmentioning

confidence: 99%

Effect of sex steroids and insulin on dehydroepiandrosterone sulfate production by hepatoma G2 cells

Pall

Nguyen

Magoffin

et al. 2009

Fertility and Sterility

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OBJECTIVE-To test the hypothesis that DHEAS production from DHEA occurs in hepatic cells, and that this production is augmented by the presence of sex steroids or insulin (INS). DESIGN-In-vitro prospective experimentSETTING-Academic medical center. RESULTS-DHEAS was first detected in the HepG2 cell culture media at 12h incubation. The cumulative production rate of DHEAS increased linearly until 72h incubation. When compared to the effect of treatment with DHEA only, treatment with DHEA plus T, DHT, or E2 delayed the cumulative DHEAS production; alternatively, the addition of INS did not alter DHEAS production. INTERVENTIONS-HepatomaCONCLUSION-These data suggest that while hepatic cells have the ability of converting DHEA to DHEAS, neither sex steroids nor INS result in the increased hepatic production of DHEAS.

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Section: Discussionmentioning

confidence: 99%

Effect of sex steroids and insulin on dehydroepiandrosterone sulfate production by hepatoma G2 cells

Pall

Nguyen

Magoffin

et al. 2009

Fertility and Sterility

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Insulin Resistance, Hyperinsulinemia, and LH: Relative Roles in Peripubertal Obesity-Associated Hyperandrogenemia

Solorzano

Knudsen

Anderson

et al. 2018

The Journal of Clinical Endocrinology &Amp; Metabolism

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In insulin-resistant obese girls with hyperinsulinemia, free testosterone levels correlated positively with insulin sensitivity and, likely, circulating LH concentrations but not with circulating insulin levels. In the setting of relatively uniform hyperinsulinemia, variable steroidogenic-cell insulin sensitivity may correlate with metabolic insulin sensitivity and contribute to variable free testosterone concentrations.

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Hyperinsulinemia does not Acutely Enhance Adrenal Androgen Production in Women or Men

Cited by 2 publications

References 15 publications

Effect of sex steroids and insulin on dehydroepiandrosterone sulfate production by hepatoma G2 cells

Effect of sex steroids and insulin on dehydroepiandrosterone sulfate production by hepatoma G2 cells

Insulin Resistance, Hyperinsulinemia, and LH: Relative Roles in Peripubertal Obesity-Associated Hyperandrogenemia

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