Hyperinsulinemia: a Cause of Obesity?

Abstract

Purpose of ReviewThis perspective is motivated by the need to question dogma that does not work: that the problem is insulin resistance (IR). We highlight the need to investigate potential environmental obesogens and toxins.Recent FindingsThe prequel to severe metabolic disease includes three interacting components that are abnormal: (a) IR, (b) elevated lipids and (c) elevated basal insulin (HI). HI is more common than IR and is a significant independent predictor of diabetes.SummaryWe hypothesize that (1) the initiating defect is HI that increases nutrient consumption and hyperlipidemia (HL); (2) the cause of HI may include food additives, environmental obesogens or toxins that have entered our food supply since 1980; and (3) HI is sustained by HL derived from increased adipose mass and leads to IR. We suggest that HI and HL are early indicators of metabolic dysfunction and treating and reversing these abnormalities may prevent the development of more serious metabolic disease.

Деякі Аспекти Медикаментозної Терапії Цукрового Діабету 2-Го Типу У Людей З Надмірною Масою Тіла

“…Роль дисфункции бета-клеток в патогенезе СД 2-го типа известна, в связи с чем следует избегать их чрезмерной стимуляции. Важно подчеркнуть, что гиперинсулинемия сама по себе способствует увеличению массы тела, дислипидемии и атеросклерозу [51,72,112,113]. С учетом изложенного при прочих равных условиях преимущество имеют препараты, действие которых не связано со стимуляцией бета-клеток.…”

Human Herpesvirus 8 and Host-Cell Interaction: Long-Lasting Physiological Modifications, Inflammation and Related Chronic Diseases

“…Overall, several findings have led to the hypothesis that HHV8 could be implicated in inducing some metabolic alterations, such as the increase of insulin binding and glucose uptake, which may be the initial event for activating the metabolic syndrome and diabetes [60,77,78,81,82,89,93]. It is commonly accepted that insulin hyper-secretion is considered a triggering cause of diabetes, and the discovery of the causes that are linked to insulin hyper-secretion is fundamental in the design of specific diabetes treatment [94,95]. The hypothesis about a possible association between HHV8 and DMT2 requires more and definite in vivo demonstrations to be confirmed.…”

Glycemic control of diabetic patients in two Family Health Units, Paraguay, 2018. Pilot study

“…Esta preponderancia por el sexo femenino podría explicarse porque las mujeres conformaron la mayor parte de esta muestra. El común denominador del aumento de la grasa (35) corporal es la resistencia a la insulina . La mayoría de los pacientes de esta muestra se hallaba en (36) tratamiento con metformina, lo cual resulta apropiado .…”