Hyperimmunoglobulin E Syndrome-like Symptoms in a Hemodialysis Patient who Developed Multiple Subcutaneous<i>Staphylococcus aureus</i> Abscesses

Abstract

Hyperimmunoglobulin E syndrome (HIES) is sporadically triggered by de novo genetic mutations of the signal transducer and activator of transcription 3 (STAT3). Dialysis patients frequently exhibit HIES-like symptoms including elevated IgE levels and recurrent bacterial infections. We herein report the case of a 74-year-old man on hemodialysis (HD) who developed marked IgE elevation and multiple subcutaneous cold Staphylococcus aureus abscesses. We are the first to report that a dialysis patient presented with HIES-like symptoms without the characteristic facies or bone and connective tissue abnormalities. A STAT3 gene analysis was conducted as part of the differential diagnosis.