Hyperimmune cow colostrum reduces diarrhoea due to rotavirus: a double‐blind, controlled clinical trial

Abstract

The therapeutic efficacy of hyperimmune bovine colostrum (HBC) from cows immunized with four serotypes of human rotavirus was evaluated in a double-blind, randomized trial in 75 boys, aged 6-24 months, infected with rotavirus diarrhoea. The treatment group received 100 ml of HBC three times a day for 3 consecutive days, while the controls received the same amount of bovine colostrum from significantly shorter duration of diarrhoea than the controls (median 56 versus 72 h (p<0.001); confidence interval of median difference (CI) 8-32 h). Total stool output (g/kg) between admission and cessation of diarrhoea was reduced by 29% in the HBC-treated group compared with controls (median 205 versus 290 g (p=0.04); CI = 1-154 g). In 50% of the children in the study group, diarrhoea stopped by 48 h, whereas 100% of the controls were still suffering from diarrhoea. No untoward effects were noted in either group. Colostrum from cows immunized with rotavirus antigen is clinically effective in reducing the duration and severity of childhood diarrhoea due to rotavirus.

The role of bovine colostrum on recovery time and length of hospital stay of acute diarrhea in infants and children: a double-blind randomized controlled trial

“…8,9 Our study shows that recovery time and length of hospital stay were shorther in the treatment group. Similar results were reported by Ylitalo et al 8 12 in Bangladesh in which oral hyperimune bovine colostrum was effective to accelerate the recovery time and the length of hospital stay for acute diarrhea caused by rotavirus in infants and children compared with control of 56 hours compared to 72 hours. Guarino et al, 13 in Italy found the length of hospital stay was 76 hours in the group of acute diarrhea caused by rotavirus given antiviral human serum immunoglobulin compared to 131 hours in control group.…”

Effect of nitazoxanide for treatment of severe rotavirus diarrhoea: randomised double-blind placebo-controlled trial

“…[7][8][9] Hyperimmune bovine colostrum from cows immunised with human rotavirus has been shown to reduce the duration and severity of childhood diarrhoea due to rotavirus. 10 A rotavirus vaccine was fi rst licensed in 1998, but was withdrawn after less than 1 year of use because of risk of intussusception. Two new vaccines have been or will soon be licensed and could be available in the next 2-3 years.…”

Clinical applications of bioactive milk components

“…Bovine antibodies have also been applied therapeutically, resulting in a significant reduction in diarrhea in rotavirus-infected children treated with antibodies isolated from colostrum produced by cows immunized against several strains of human rotavirus. 14 The evaluation of bovine colostrum antibodies against Cryptosporidium parvum,…”