Hypericum perforatum use during pregnancy and pregnancy outcome

Kolding, Line; Pedersen, Lars Henning; Henriksen, Tine Brink; Olsen, Jørn; Grzeskowiak, Luke E.

doi:10.1016/j.reprotox.2015.10.003

Cited by 17 publications

(24 citation statements)

References 14 publications

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“…There are some herbal medicines which can be used safely during pregnancy, for example, air plant (Bryophyllum pinnatum) for sleep quality, German chamomile (Matricaria recutita L.) as an antiinflammatory and uterine tonic but also for anxiety, nausea, and vomiting, peppermint (Mentha × piperita L.) is the most commonly used for indigestion/heartburn and nausea/morning sickness, whereas echinacea (Echinacea sp. L.) is used to prevent or treat cold or the flu and in general boost the immune system; and ginger (Zingiber officinale Roscoe) is a common herb for nausea and vomiting with potential mild adverse effects such as drowsiness and heartburn (Araújo, Santiago, Peixoto, de Oliveira, & de Sousa Coutinho, 2016;Bishop, Northstone, Green, & Thompson, 2011;Broussard, Louik, Honein, & Mitchell, 2010;Dennehy, 2011;Holst, Wright, Haavik, & Nordeng, 2011;Kolding, Pedersen, Henriksen, Olsen, & Grzeskowiak, 2015;Moretti, Maxson, Hanna, & Koren, 2009;Petersen, McCrea, Lupattelli, Nordeng, 2015;Orief et al, 2014;Viljoen, Visser, Koen, & Musekiwa, 2014;Wang, Li, San Lau, Leung, & Fung, 2013). However, clinical data concerning safety of maternal exposure to herbal medicines during pregnancy are often inconclusive due to small sample sizes, ethical reservations, and incomplete study designs.…”

Section: Causes Of Adverse Reactions From the Use Of Herbal Medicinementioning

confidence: 99%

“…A review of clinical studies attempted to summarize and alert healthcare professionals to the fact that herbal medicines are not entirely free of risks for pregnant or lactating women. Tables and summarize common herbal medicines and their potential adverse effects during pregnancy which include teratogenic, mutagenic, genotoxic, emmenagogue, abortifacient, uterine stimulant, oxytocic, and other effects (Baum, ; Blumenthal et al, ; Brinker, ; Broussard et al, ; Buehler, ; Ernst, ; Goel, Prabha, Kumar, Dorababu, & Prakash, ; Han et al, ; Kolding et al, ; Kristanc & Kreft, ; National Research Council, ; Ouedraogo et al, ; Petersen et al, ; L. D. Zhang et al, ).…”

Section: Specific Considerations For the Use Of Herbal Medicines Durimentioning

confidence: 99%

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Pregnancy and herbal medicines: An unnecessary risk for women's health—A narrative review

Bruno

Simões

et al. 2018

Phytotherapy Research

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The indiscriminate use of herbal medicines to prevent or to heal diseases or even the use for questionable purposes such as weight loss has received both interest and scrutiny from the scientific community and general public alike. An increasing number of women put their own and the unborn child's health at risk due to a lack of knowledge about the phytochemical properties and adequate use of herbal medicine (phytomedicines or herbal supplements) and lack of communication with their healthcare provider. The purpose of this narrative review was to summarize the use of herbal medicines during pregnancy and their potential toxic effects to highlight the importance of caution when prescribing herbal medicines or supplements for women, because, in addition to suffering interactions and a great amount of information obtained in preclinical predictive studies, assessment of nephrotoxicity, neurotoxicity, hepatotoxicity, genotoxicity, and teratogenicity of traditional medicinal herbs still remains scarce in the clinical setting.

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Section: Causes Of Adverse Reactions From the Use Of Herbal Medicinementioning

confidence: 99%

Section: Specific Considerations For the Use Of Herbal Medicines Durimentioning

confidence: 99%

Pregnancy and herbal medicines: An unnecessary risk for women's health—A narrative review

Bruno

Simões

et al. 2018

Phytotherapy Research

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“…Iako je prevalenca bila zasnovana na samo tri slučaja i malformacije nisu bile specifične, autori su skrenuli pažnju na slučaj hipospadije, koji je bio zabeležen i u studiji koju su sproveli Moretti i saradnici, i čija je prevalenca (zbirno u obe studije dva slučaja od 40 novorođenčadi muškog pola, tj. 5%) bila veća u odnosu na očekivanu (u Danskoj 2005. godine prevalenca hipospadije iznosila je 0,5%) (36). U svakom slučaju, za pouzdano utvrđivanje uticaja ekstrakata herbe kantariona na ishod trudnoće potrebna su dalja ispitivanja.…”

Section: Klinička Bezbednost Mere Opreza Interakcije Kontraindikacijeunclassified

Herbal medicinal products in the treatment of depression

Petrović¹

2017

Arhiv za farmaciju

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Kratak sadržaj Za suve vodenoalkoholne ekstrakte herbe kantariona, Hyperici herba (Hypericum perforatum, Hypericaceae), u kliničkim studijama je pokazano da su u slučaju blage i umerene (ali ne i teške) velike depresije značajno efikasniji od placeba, i da je njihova efikasnost uporediva sa nekim sintetskim antidepresivima. Ovi ekstrakti predstavljaju složene smeše hemijski različitih sastojaka koji deluju različitim mehanizmima. Količina aktivnih sastojaka među različitim ekstraktima može da varira. Komitet za biljne lekovite proizvode Evropske agencije za lekove (EMA/HMPC) izdao je monografiju za herbu kantariona, Hyperici herba, prema kojoj se na bazi ovih ekstrakata izrađuju biljni lekovi sa dobro dokumentovanom upotrebom aktivne supstance (eng. well-established medicinal use), namenjeni za terapiju blagih do umerenih depresivnih epizoda i kratkotrajnu terapiju blagih depresivnih poremećaja. Ove biljne lekove karakteriše dobra podnošljivost. U odnosu na sintetske antidepresive izazivaju manje neželjenih dejstava. Međutim, biljni lekovi na bazi suvih vodenoalkoholnih ekstrakata herbe kantariona ispoljavaju interakcije sa velikim brojem lekova zahvaljujući indukciji izoenzima sistema citohrom P450 (CYP, prvenstveno CYP3A4) i P-glikoproteina, kao i potenciranju serotoninskih efekata. Zbog navedenih interakcija ustanovljene su odgovarajuće kontraindikacije i posebna upozorenja i mere opreza vezane za primenu ovih biljnih lekova. Ključne reči: herba kantariona-Hyperici herba, biljni lekovi za tretman depresije, kvalitet, efikasnost i mehanizmi delovanja, bezbednost. Rad saopšten na 68. simpozijumu Saveza farmaceutskih udruženja Srbije u okviru seminara SAVREMENI PRISTUP LEČENJU DEPRESIJE.

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“…There is limited research investigating the safety of SJW in pregnancy and lactation in women. We found two observational studies investigating the effects of SJW exposure during pregnancy (Kolding, Pedersen, Henriksen, Olsen, & Grzeskowiak, ; Moretti, Maxson, Hanna, & Koren, ) and one during lactation (Lee, Minhas, Matsuda, Lam, & Ito, ). Neither of these found any statistically significant differences in pregnancy or neonatal health outcomes.…”

Section: Introductionmentioning

confidence: 99%

The safety of St John's wort (Hypericum perforatum) in pregnancy and lactation: A systematic review of rodent studies

Avila

Whitten

Evans

2018

Phytotherapy Research

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Herbal products are popular among women during the perinatal period. St John's wort (SJW), Hypericum perforatum, is a common remedy for mild depression, a problem prevalent in this population. Although the safety of herbal products must be investigated, ethical issues constrain intervention studies in humans. Hence, animal studies often inform clinical decisions. The objective of this study is to systematically review rodent studies assessing the safety of SJW during the perinatal period. A literature search to November 10, 2017, identified 10 rodent studies that met a priori inclusion criteria. Study quality was evaluated according to both the Systematic Review Centre for Laboratory animal Experimentation tool for assessing bias and recommendations for appropriate reporting of herbal medicine research. Significant methodological limitations were found in each of the studies reviewed. These limitations include the lack of botanical verification and omission of extract characterization, inadequate explanation of dosage rationale, and absence of bias limiting protocols. Critical appraisal with contemporary tools indicates that each of the reviewed studies lacks appropriate rigour, rendering the results unreliable. Despite this, these papers are used in the rationale for recommending or contraindicating SJW during pregnancy and lactation.

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Hypericum perforatum use during pregnancy and pregnancy outcome

Cited by 17 publications

References 14 publications

Pregnancy and herbal medicines: An unnecessary risk for women's health—A narrative review

Pregnancy and herbal medicines: An unnecessary risk for women's health—A narrative review

Herbal medicinal products in the treatment of depression

The safety of St John's wort (Hypericum perforatum) in pregnancy and lactation: A systematic review of rodent studies

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