Hypericum perforatum to improve post-operative Pain Outcome after monosegmental Spinal microdiscectomy (HYPOS): a study protocol for a randomised, double-blind, placebo-controlled trial

Raak, Christa; Scharbrodt, Wolfram; Berger, Bettina; Büssing, Arndt; Geissen, Rene; Ostermann, Thomas

doi:10.1186/s13063-018-2631-6

Cited by 6 publications

(1 citation statement)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hypericum perforatum L., known as St. John's wort, is a medicinal herbal plant belonging to family Clusiaceae with a long history of utilization in different medical targets such as neurological disorders like mental aliments (Shrivastava & Dwivedi, 2015), headache (Rajapakse & Davenport, 2019), coxalgia (Oztürk et al, 1996), spastic paralysis (Oztürk et al, 1996), menopausal neurosis (van Die, 2010), irritation (Özdemir Ü et al, 2016; Raak et al, 2018), hypersensitivity (de Melo Wde et al, 2013), neuralgia (Assiri et al, 2017), spinal convulsion and stiff neck (Raak et al, 2012), tetanus (Sümeli et al, 2022), hypotensive, analgesic, anti‐infective, antioxidant, and spasmolytic properties (Allegra et al, 2020). H. perforatum L. is able to improve the rate of tissue regeneration via increasing fibroblast proliferation, collagen fiber production, and revascularization (Ashkani‐Esfahani et al, 2019; Okur et al, 2020; Yadollah‐Damavandi et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

The potential role of Hypericum perforatum in wound healing: A literature review on the phytochemicals, pharmacological approaches, and mechanistic perspectives

Farasati Far,

Gouranmohit,

Naimi‐jamal

et al. 2024

Phytotherapy Research

View full text Add to dashboard Cite

St. John's Wort, commonly known as Hypericum perforatum L., is a flowering plant in the Clusiaceae family that traditionally been employed for treating anxiety, depression, wounds, burns, sunburn, irritation, and stomach ailments. This review provides a synopsis of H. perforatum L. phytoconstituents and their biological effects, highlighting its beneficial therapeutic properties for dermatological indications, as well as its antioxidant, antimicrobial, anti‐inflammatory, and anti‐angiogenic activity in various applications including wound healing and skin conditions such as eczema, sun burn and minor burns also spastic paralysis, stiff neck and mood disorders as anti‐depressant and nerve pains such as neuralgia. The data were collected from several databases as Web of Science PubMed, ScienceDirect, Scopus and Google Scholar using the terms: “H. perforatum L.”, “H. perforatum L. /phytochemistry,” and “H. perforatum extracts/wound healing” collected from 1994 to 2023. The findings suggest H. perforatum L. acts through various mechanisms and plays a role in each phase of the wound healing process, including re‐epithelialization, angiogenesis, wound contraction, and connective tissue regeneration. H. perforatum L. enhances collagen deposition, decreases inflammation, inhibits fibroblast migration, and promotes epithelialization by increasing the number of fibroblasts with polygonal shape and the number of collagen fibers within fibroblasts. H. Perforatum L. extracts modulate the immune response and reduce inflammation were found to accelerate the wound healing process via inhibition of inflammatory mediators' production like interleukin‐6, tumor necrosis factor‐α, cyclooxygenase‐2 gene expression, and inducible nitric oxide synthase. Thus, H. perforatum L. represents a potential remedy for a wide range of dermatological problems, owing to its constituents with beneficial therapeutic properties. H. perforatum L. could be utilized in the development of novel wound healing therapies.

show abstract