Hypericum perforatum extract attenuates behavioral, biochemical, and neurochemical abnormalities in Aluminum chloride-induced Alzheimer’s disease rats

Cao, Zheng; Fan, Wei; Xiu, Chunyu; Zhang, Jian; Li, Yanfei

doi:10.1016/j.biopha.2017.05.022

Cited by 74 publications

(42 citation statements)

References 52 publications

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“…Those models included: administration of aluminum chloride per os (p.o.) [113], intraperitoneal (i.p.) administration of scopolamine [114,115], intracerebroventricular (i.c.v.)…”

Section: Experimental Models Of Admentioning

confidence: 99%

Potential of Caffeine in Alzheimer’s Disease—A Review of Experimental Studies

et al. 2021

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Alzheimer’s disease (AD) is the most common type of dementia leading to progressive memory loss and cognitive impairment. Considering that pharmacological treatment options for AD are few and not satisfactory, increasing attention is being paid to dietary components that may affect the development of the disease. Such a dietary component may be caffeine contained in coffee, tea or energy drinks. Although epidemiological data suggest that caffeine intake may counteract the development of cognitive impairment, results of those studies are not conclusive. The aim of the present study is to review the existing experimental studies on the efficacy of caffeine against AD and AD-related cognitive impairment, focusing on the proposed protective mechanisms of action. In conclusion, the reports of studies on experimental AD models generally supported the notion that caffeine may exert some beneficial effects in AD. However, further studies are necessary to elucidate the role of caffeine in the effects of its sources on cognition and possibly AD risk.

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“…Those models included: administration of aluminum chloride per os (p.o.) [113], intraperitoneal (i.p.) administration of scopolamine [114,115], intracerebroventricular (i.c.v.)…”

Section: Experimental Models Of Admentioning

confidence: 99%

Potential of Caffeine in Alzheimer’s Disease—A Review of Experimental Studies

et al. 2021

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“…Preceding results demonstrated that the administration of AlCl 3 (17 mg/kg body weight daily for 4 successive weeks) which known as an environmental toxin, widely used for induction in Alzheimer disease (AD) rat model to explore the etiology and therapeutic strategies of AD [19]. It induced neurotoxicity in aged rats causing neuroinflammation, extracellular Ab generation, and aggregation, and neurofibrillary tangles in addition to oxidative stress through multiple mechanisms led to imbalance between oxidants and antioxidants with a significant decrease in brain/serum As results finding in our both previous study, the hydroacetonic extract was ameliorated the biochemical parameters of oxidative stress, endothelial dysfunction, and inflammation not only in AD induced rats but also in aged normal rats by quenching free radicals.…”

Section: 2the Chemical Composition Of Polyphenol Extractsmentioning

confidence: 99%

Optimization of polyphenol extraction from Vitis vinifera L. leaves, antioxidant activity and its correlation with amelioration effect on AlCl3-induced Alzheimer’s disease

Matloub

2018

Archives of Pharmaceutical Sciences Ain Shams University

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This research focused on optimization of polyphenol extraction from Vitis vinifera L. (cv. Flame Seedless) leave based on 2,2-diphenyl-1-picrylhydrazyl (DPPH•) scavenging capability in additional discussion of structure-activity relationship according to its amelioration effect on AlCl3-induced Alzheimer's disease. The highest extraction yield was found for acidified aqueous solvents. While the highest total phenolic and flavonoid contents were found for aqueous solvents. The hydroacetonic extract showed significantly superior content in total phenolic and flavonoid accompanied by highest DPPH scavenging capability than other tested extracts. High-Performance Liquid Chromatography with Diode-Array Detection (HPLC/DAD) analysis of extracts led to identifying catechin, rutin, isoquercetin, quercitrin, apigenin-7-O-glucoside, quercetin, kaempferol and myricetin for the first time in V. vinifera L. (cv. Flame Seedless) leaves. In addition, quercetin-3-O-β-D-arabinopyranoside was isolated for the first time from V. vinifera L., detected as a major flavonoid in all extracts. This study emphasized the role of solvents played in polyphenol extraction and antioxidant activity from V. vinifera L. (cv. Flame Seedless) leaves. The hydroacetonic extract mainly composed of flavonoidal compounds which could ameliorate AlCl3-induced cerebral damages and neurocognitive dysfunction. This may lead to the development of new nutraceutical and pharmaceutical agents used as anti-oxidative stress and neuroprotective agent on Alzheimer and aging diseases.

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“…Many investigations have demonstrated that heavy metals are correlated with neurodegenerative disorders such as AD and Parkinson’s disease (PD) [ 6 ]. Aluminum (Al) is one of the heavy metals involved in neurodegenerative disease development, as it affects several cellular metabolic pathways in the central nervous system (CNS) [ 7 ]. The preference of using aluminum chloride (AlCl 3 ) was compounded on the fact that it is found in many manufactured foods, toothpaste, medicines, and in purified drinking water [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

The Possible Neuroprotective Effect of Silymarin against Aluminum Chloride-Prompted Alzheimer’s-Like Disease in Rats

et al. 2020

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Alzheimer’s disease (AD) is a worldwide rapidly growing neurodegenerative disease. Here, we elucidated the neuroprotective effects of silymarin (SM) on the hippocampal tissues of aluminum chloride (AlCl3)-induced Alzheimer-like disease in rats using biochemical, histological, and ultrastructural approaches. Forty rats were divided into control, SM, AlCl3, and AlCl3 + SM groups. Biochemically, AlCl3 administration resulted in marked elevation in levels of lipid peroxidation (LPO) and nitric oxide (NO) and decrease in levels of reduced glutathione (GSH), catalase (CAT), and superoxide dismutase (SOD). Moreover, AlCl3 significantly increased tumor necrosis factor-α (TNF-α), interleukin-1beta (IL-1β), and acetylcholinesterase (AChE) activities. Furthermore, myriad histological and ultrastructural alterations were recorded in the hippocampal tissues of AlCl3-treated rats represented as marked degenerative changes of pyramidal neurons, astrocytes, and oligodendrocytes. Additionally, some myelinated nerve fibers exhibited irregular arrangement of their myelin coats, while the others revealed focal degranulation of their myelin sheaths. Severe defects in the blood–brain barrier (BBB) were also recorded. However, co-administration of SM with AlCl3 reversed most of the biochemical, histological, and ultrastructural changes triggered by AlCl3 in rats. The results of the current study indicate that SM can potentially mend most of the previously evoked neuronal damage in the hippocampal tissues of AlCl3-kindled rats.

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Hypericum perforatum extract attenuates behavioral, biochemical, and neurochemical abnormalities in Aluminum chloride-induced Alzheimer’s disease rats

Cited by 74 publications

References 52 publications

Potential of Caffeine in Alzheimer’s Disease—A Review of Experimental Studies

Potential of Caffeine in Alzheimer’s Disease—A Review of Experimental Studies

Optimization of polyphenol extraction from Vitis vinifera L. leaves, antioxidant activity and its correlation with amelioration effect on AlCl3-induced Alzheimer’s disease

The Possible Neuroprotective Effect of Silymarin against Aluminum Chloride-Prompted Alzheimer’s-Like Disease in Rats

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