Hypericum japonicum: a Double-Headed Sword to Combat Vector Control and Cancer

Puthur, Sreedev; Anoopkumar, A. N.; Rebello, Sharrel; Aneesh, Embalil Mathachan

doi:10.1007/s12010-018-2713-7

Cited by 22 publications

(7 citation statements)

References 30 publications

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“…These results were also confirmed by a third study [56]. The data suggested that H. japonicum plant extracts at very small levels were strong cytotoxic factors.…”

Section: Figure 2 Activity Of Hyperforin (Hf)supporting

confidence: 64%

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Antiproliferative Effects of St. John’s Wort, Its Derivatives, and Other Hypericum Species in Hematologic Malignancies

Allegra

Tonacci

Spagnolo

et al. 2020

IJMS

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Hypericum is a widely present plant, and extracts of its leaves, flowers, and aerial elements have been employed for many years as therapeutic cures for depression, skin wounds, and respiratory and inflammatory disorders. Hypericum also displays an ample variety of other biological actions, such as hypotensive, analgesic, anti-infective, anti-oxidant, and spasmolytic abilities. However, recent investigations highlighted that this species could be advantageous for the cure of other pathological situations, such as trigeminal neuralgia, as well as in the treatment of cancer. This review focuses on the in vitro and in vivo antitumor effects of St. John’s Wort (Hypericum perforatum), its derivatives, and other Hypericum species in hematologic malignancies. Hypericum induces apoptosis in both myeloid and lymphoid cells. Other Hypericum targets include matrix metalloproteinase-2, vascular endothelial growth factor, and matrix metalloproteinase-9, which are mediators of cell migration and angiogenesis. Hypericum also downregulates the expression of proteins that are involved in the resistance of leukemia cells to chemotherapeutic agents. Finally, Hypericum and its derivatives appear to have photodynamic effects and are candidates for applications in tumor photodynamic therapy. Although the in vitro studies appear promising, controlled in vivo studies are necessary before we can hypothesize the introduction of Hypericum and its derivatives into clinical practice for the treatment of hematologic malignancies.

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“…These results were also confirmed by a third study [56]. The data suggested that H. japonicum plant extracts at very small levels were strong cytotoxic factors.…”

Section: Figure 2 Activity Of Hyperforin (Hf)supporting

confidence: 64%

“…The dosage necessary to destroy 50% of the DLA cells for hexane extracts and petroleum ether were 38.57 and 38.89 ppm, respectively. The smallest LD50 was displayed by methanolic extract with a concentration of 60.20 ppm [56].…”

Section: Figure 2 Activity Of Hyperforin (Hf)mentioning

confidence: 95%

Antiproliferative Effects of St. John’s Wort, Its Derivatives, and Other Hypericum Species in Hematologic Malignancies

Allegra

Tonacci

Spagnolo

et al. 2020

IJMS

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“…The methanolic extract proved the most active, its purified fraction displaying LC 50 0.95 μg/mL. The major constituents of this active fraction were isopropyl palmitate ( 19 ), 2,4-Di- tert -butylphenol ( 20 ) and hydrocinnamic acid ( 21 ) [ 97 ]. Similarly active, the Nerine sarniensis (L.) Herb.…”

Section: Organic/aqueous Extractsmentioning

confidence: 99%

“…64.58 µg/mL), ethyl acetate (LC50 72.77 µg/mL), chloroform (LC50 88.20 µg/mL) and benzene (LC50 97.03 µg/mL)[103]. Extracts of three other species obtained from the same plant part with different organic solvents were also evaluated.The methanolic extracts were the most active: Acalypha alnifolia Klein ex Willd.…”

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confidence: 99%

Plant Natural Products for the Control of Aedes aegypti: The Main Vector of Important Arboviruses

et al. 2020

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The mosquito species Aedes aegypti is one of the main vectors of arboviruses, including dengue, Zika and chikungunya. Considering the deficiency or absence of vaccines to prevent these diseases, vector control remains an important strategy. The use of plant natural product-based insecticides constitutes an alternative to chemical insecticides as they are degraded more easily and are less harmful to the environment, not to mention their lower toxicity to non-target insects. This review details plant species and their secondary metabolites that have demonstrated insecticidal properties (ovicidal, larvicidal, pupicidal, adulticidal, repellent and ovipositional effects) against the mosquito, together with their mechanisms of action. In particular, essential oils and some of their chemical constituents such as terpenoids and phenylpropanoids offer distinct advantages. Thiophenes, amides and alkaloids also possess high larvicidal and adulticidal activities, adding to the wealth of plant natural products with potential in vector control applications.

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“…27 Hence, currently, the scientific community has drawn attention from natural products since the plants have been a prominent source of traditional medication with the tiniest toxicity to domestic animals and mankind. 21,22 An inevitable effect of phytochemical exposure to mosquito larvae is cellular and metabolic damage. The introduction of phytochemicals from plant extract or natural insecticides may augment Reactive Oxygen Species (ROS).…”

Section: Introductionmentioning

confidence: 99%

Activation of the Oxidative Stress in Culexquinquefasciatus by the Augmented Productionof Reactive Oxygen Species (ROS) in responseto Stachytarpheta jamaicensis Exposure

Rajan

2021

JCD

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Introduction: Plant-based knowledge has been used for generations for personal protection from various mosquito species. The notion of applying such traditional perspectives in vector control research has received extensive attention in recent years. Unlike other common patterns, the present investigation has tried to explore the augmented production of reactive oxygen species (ROS) in response to Stachytarpheta jamaicensis exposure with special inference on larvicidal potential, mode of action of phytochemical compounds, and oxidative stress. Methods: The larvicidal potential was determined as per the WHO protocol. Ultraviolet-visible spectroscopy was used to determine the excessive production of ROS. GC-MS was employed to characterise the phytochemical constituents. The statistical analysis was done by using SPSS version 24.0.0. Result: The acetone extract has been found to exhibit a maximum range of toxicity in terms of larvicidal potential and reactive oxygen species formation. Among the 40 phytochemical elements characterised, Cyclopropane, 1,1,2,2-Tetramethyl; Phenyl-Acetonitrile; Pyranone; Tetradecene; Neophytadiene; Mome Inositol; Monocrotaline; and Squalene may be responsible for the augmented production of ROS in the Culex quinquefasciatus. Conclusion: The phytochemical elements in Stachytarpheta jamaicensis displayed extensive toxicity and inhibited the normal development of Culex quinquefasciatus mosquitoes by augmented production of reactive oxygen species, indicating its prominent role in oxidative stress.

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Hypericum japonicum: a Double-Headed Sword to Combat Vector Control and Cancer

Cited by 22 publications

References 30 publications

Antiproliferative Effects of St. John’s Wort, Its Derivatives, and Other Hypericum Species in Hematologic Malignancies

Antiproliferative Effects of St. John’s Wort, Its Derivatives, and Other Hypericum Species in Hematologic Malignancies

Plant Natural Products for the Control of Aedes aegypti: The Main Vector of Important Arboviruses

Activation of the Oxidative Stress in Culexquinquefasciatus by the Augmented Productionof Reactive Oxygen Species (ROS) in responseto Stachytarpheta jamaicensis Exposure

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