Hypericin-loaded oil-in-water nanoemulsion synthesized by ultrasonication process enhances photodynamic therapy efficiency

Ling, Hui; Varanda, Laudemir Carlos; Perussi, Janice Rodrigues; Carrilho, Emanuel

doi:10.1016/j.jphotobiol.2021.112303

Cited by 18 publications

(5 citation statements)

References 58 publications

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“…2 whenever necessary to maintain effective torque ratio between (15-85%) as per instrument manual. The shear force was increased at 4 pre-defined speed (12, 30, 60, 100) and the correspondent dynamic viscosity was measured in units of (mPa.sec) (19) .…”

Section: Viscositymentioning

confidence: 99%

Formulation and Evaluation of Idebenone Microemulsion as a Potential Approach for the Transmucosal Drug Delivery Systems

Jaafer,

Al-Kinani

2024

IJPS

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Idebenone, a synthetic analogue of ubiquinone (Co-Q10), is used for the treatment of Leiber’s hereditary optic neuropathy. Although it is almost completely absorbed from GIT, its extensive rate of metabolism makes its oral bioavailability less than 1%. This study aims to formulate the poorly water-soluble drug as nanoemulsion (NE) to increase drug solubility as well as transmucosal permeation and circumventing hepatic biodegradation by using transmucosal routes of administration such as intranasal rout to enhance drug bioavailability. Nanoemulsion components were selected through screening of the preferential solubility of IDB in several oils and emulsifying agents and subsequent formulation optimization through screening for their best miscibility through phase study. Lemongrass oil showed superior characteristics to represent the oil phase in which the drug was dissolved while Cremophor EL® and Transcutol-P® represented the surfactant system. The method of spontaneous-emulsification was used to prepare twelve NE formulas (F1-F12) which were subjected to several characterization tests. Out of four successful formulas, F-11 showed the best globule size (45.6nm), PDI (0.19) zeta-potential (-2.8 mV), low viscosity and suitable pH (5.9). Using sheep nasal mucosa as model, (F-11) was subjected to ex-vivo transmucosal permeation study against plain drug oil dispersion with pronounced enhanced permeation due to formulation as NEs. Permeation kinetic parameters were obtained such as permeation rate 40.9 µg/h/cm2, lag time 15min, permeability coefficient 40.9x10-4 cm/h and enhancement ratio 39. The outcome of this study indicates the possibility of incorporation of this formula into a suitable carrier for finalizing its formulation as non-enteral dosage form with enhanced IDB bioavailability.

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Section: Viscositymentioning

confidence: 99%

Formulation and Evaluation of Idebenone Microemulsion as a Potential Approach for the Transmucosal Drug Delivery Systems

Jaafer,

Al-Kinani

2024

IJPS

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“…Nanoemulsions (NEs) consist of droplets with diameters equal to or less than 100 nm [133], with an oil content varying from 5 to 20% w/v [134]. Some specific NEs may use a combination of oils to enhance the solubility of drugs.…”

Section: Nanoemulsionmentioning

confidence: 99%

Nanotechnology-Enhanced Cosmetic Application of Kojic Acid Dipalmitate, a Kojic Acid Derivate with Improved Properties

Ayuhastuti,

Syah,

Megantara

et al. 2024

Cosmetics

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Kojic acid (KA) has emerged as a prominent tyrosinase inhibitor with considerable potential in cosmetic applications; however, its susceptibility to instability during storage poses a challenge to its widespread use. This review explores the advancements in addressing this limitation through the development of various KA derivatives, focusing on the modification of the C-7 hydroxyl group. Strategies such as esterification, hydroxy-phenyl ether formation, glycosylation, and incorporation into amino acid or tripeptide derivatives have been employed to enhance stability and efficacy. Among these derivatives, Kojic Acid Dipalmitate (KDP), a palmitic ester derivative of KA, stands out for its notable improvements in stability, permeability, and low toxicity. Recent developments indicate a growing utilization of KDP in cosmetic formulations, with over 132 available products on the market, encompassing various formulations. Formulations based on nanotechnology, which incorporate KDP, have been provided, including nanosomes, nanocreams, multiple emulsions, liposomes, solid lipid nanoparticles (SLNs), ethosomes, and nanoemulsions. Additionally, three patents and seven advanced system deliveries of KDP further underscore its significance. Despite its increasing prevalence, the literature on KDP remains limited. This review aims to bridge this gap by providing insights into the synthesis process, physicochemical properties, pharmaceutical preparation, diverse applications of KDP in cosmetic products, and recent nanotechnology formulations of KDP. This review paper seeks to explore the recent developments in the use of KDP in cosmetics. The goal is to enhance stability, permeability, and reduce the toxicity of KA, with the intention of promoting future research in this promising sector.

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“…A surfactant is necessary for facilitating the formation of, and improving the kinetic stability of, NEs. Research has demonstrated the critical role of an appropriate surfactant concentration in maintaining the stability of NEs [34]. Consequently, we investigated the effects of varying concentrations of the surfactant (glycyrrhizic acid).…”

Section: Single Factor Experiments To Optimize the Prescription Of Bb...mentioning

confidence: 99%

Fabrication and Biological Activities of All-in-One Composite Nanoemulsion Based on Blumea balsamifera Oil-Tea Tree Oil

et al. 2023

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Nanoemulsion is a new multi-component drug delivery system; the selection of different oil phases can give it special physiological activity, and play the role of “medicine and pharmaceutical excipients all-in-one”. In this paper, we used glycyrrhizic acid as the natural surfactant, and Blumea balsamifera oil (BB) and tea tree oil (TTO) as the mixed oil phase, to obtain a new green functional composite nanoemulsion. Using the average particle size and polydispersion index (PDI) as the evaluation criteria, the effects of the oil ratio, oil content, glycyrrhizic acid concentration, and ultrasonic time on the nanoemulsion were systematically investigated. The stability and physicochemical properties and biological activities of BB-TTO NEs prepared via the optimum formulation were characterized. The optimal prescription was BB: TTO = 1:1, 5% oil phase, 0.7% glycyrrhizic acid, and 5 min ultrasonication time. The mean particle size, PDI, and zeta potential were 160.01 nm, 0.125, and −50.94 mV, respectively. The nanoemulsion showed non-significant changes in stability after centrifugation, dilution, and 120 days storage. These nanoemulsions were found to exhibit potential antibacterial and anti-inflammatory activities. The minimal inhibitory concentration (MIC) of BB-TTO NEs against Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa is 2975 μg/mL, 2975 μg/mL, and 5950 μg/mL, respectively. A lower level of inflammatory cell infiltration and proportion of fibrosis were found in the synovial tissue of AIA rats treated with BB-TTO NEs. These findings demonstrate that the BB-TTO NEs produced in this study have significant potential for usage in antibacterial and anti-inflammatory areas.

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Hypericin-loaded oil-in-water nanoemulsion synthesized by ultrasonication process enhances photodynamic therapy efficiency

Cited by 18 publications

References 58 publications

Formulation and Evaluation of Idebenone Microemulsion as a Potential Approach for the Transmucosal Drug Delivery Systems

Formulation and Evaluation of Idebenone Microemulsion as a Potential Approach for the Transmucosal Drug Delivery Systems

Nanotechnology-Enhanced Cosmetic Application of Kojic Acid Dipalmitate, a Kojic Acid Derivate with Improved Properties

Fabrication and Biological Activities of All-in-One Composite Nanoemulsion Based on Blumea balsamifera Oil-Tea Tree Oil

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