Hyperhomocysteinemia, low vitamin B12, and low folic acid: Are risk factors of cerebral vascular thrombosis in northwest Iran?

Taheraghdam, Aliakbar; DalirAkbari, Nooriyeh; Khalili, Mohammad; Soltani, M.; Ahari, Saeid Sadeghieh

doi:10.4103/1735-1995.178755

Cited by 8 publications

(3 citation statements)

References 17 publications

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“…Soltani et al . revealed in their study that patients with cerebral venous thrombosis had higher levels of homocysteine with low vitamin B 12 levels as compared to controls [15]. Cantu et al .…”

Section: Discussionmentioning

confidence: 99%

An uncommon presentation of hyperhomocysteinemia and vitamin B12 deficiency: a case report

2019

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Introduction Cerebral venous thrombosis is relatively rare and characterized by a wide spectrum of clinical features. It is more common in young adults with women affected more than men. The diagnosis of cerebral venous thrombosis is easier nowadays due to easy access to advanced neuroimaging techniques. Abnormalities in thrombophilic profile are associated with enhanced risk of cerebral venous thrombosis. It has varied etiologies such as hypercoagulable states, infection, dehydration, pregnancy, and substance abuse. Hyperhomocysteinemia is found to be closely associated with an enhanced risk of cerebral venous thrombosis. Case presentation Here we report a case of cerebral venous thrombosis secondary to hyperhomocysteinemia caused by vitamin B 12 deficiency in a 32-year-old Indo-Aryan man. A detailed coagulation workup led us to find the etiology of cerebral venous thrombosis in this patient who followed a strict vegetarian diet and had vitamin B 12 deficiency leading to hyperhomocysteinemia. Conclusion There are conflicting reports in the literature about the association of hyperhomocysteinemia, B 12 deficiency, and cerebral venous thrombosis but some reports point to a significant association. We conclude that further studies with a large sample size are required to analyze the effect of hyperhomocysteinemia and low vitamin B 12 on the risk of cerebral venous thrombosis.

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Section: Discussionmentioning

confidence: 99%

An uncommon presentation of hyperhomocysteinemia and vitamin B12 deficiency: a case report

2019

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“…HHcy is an independent putative risk factor for cardiovascular diseases [ 34 ]. Folic acid deficiency is implicated in the remethylation pathway of Hcy metabolism [ 35 ]. Hcy is supposed to induce oxidative stress and endothelial dysfunction [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

Synergistic Effect of Atorvastatin and Folic Acid on Cardiac Function and Ventricular Remodeling in Chronic Heart Failure Patients with Hyperhomocysteinemia

Peng

et al. 2018

Med Sci Monit

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BackgroundAt present, a constant progress in pathophysiology understanding and treatment of the chronic heart failure (CHF) is arising. Meanwhile, hyperhomocysteinemia (HHcy) has been linked to impaired left ventricular function and clinical class in patients with CHF. Atorvastatin therapy can reduce the incidence of sudden cardiac death in patients with advanced CHF. Folic acid could enhance endothelial function in vascular disease states. The present study aims to investigate the effect of atorvastatin and folic acid combined on the cardiac function and ventricular remodeling in CHF patients with HHcy.Material/MethodsElderly CHF patients with HHcy were divided into four groups: routine, routine + atorvastatin, routine + folic acid, and routine + atorvastatin + folic acid groups. Serum homocysteine (Hcy) level was detected using enzymatic cycling methods, and N-terminal pro brain natriuretic peptide (NT-proBNP) level by ELISA. The cardiac function indexes and left ventricular early diastolic peak flow velocity/atrial systolic peak flow velocity (E/A) ratio were evaluated. The six-minute walk test was performed to measure the six-minute walk distance (6MWD).Results6MWD increased, the serum Hcy and NT-proBNP levels decreased, and cardiac function was improved compared with before treatment, which was the most significant in the routine + atorvastatin + folic acid group, followed by the routine + atorvastatin group, then the routine + folic acid group, and lastly, the routine group.ConclusionsThe results indicated that the combination of atorvastatin and folic acid improved the cardiac function and inhibited ventricular remodeling of elderly CHF patients with HHcy.

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“…По результатам метаанализа эпидемиологических исследований подтверждено, что понижение уровня фолатов и витамина B 12 является независимым фактором риска венозных тромбозов [33]. Гипергомоцистеинемия и низкий уровень витамина B 12 являются факторами риска цереброваскулярного тромбоза [34], который повышается при длительном пребывании…”

Section: противодействие тромбофилииunclassified

On the prospects for the use of thiamine, pyridoxine, and cyanocobalamin in the complex therapy and rehabilitation of patients with COVID-19

Громова

Торшин

Чучалин

2021

Pulʹmonologiâ (Mosk.)

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The new coronavirus infection COVID-19 has highlighted the importance of ongoing support for innate antiviral immunity systems. The aim. Conduct a systematic review of publications on the research of the use of B vitamins to support immunity and rehabilitation of patients with COVID-19. Methods. Intelligent analysis of so-called Big Data and special computational methods for analyzing Big Data of biomedical publications, based on the topological theory of sentiment analysis of medical texts from PubMed/MEDLINE. Results. Low levels of B vitamins contribute to chronic comorbidities and aggravate the clinical course of COVID-19 significantly. Increasing the supply of B vitamins in COVID-19 patients is essential for the maintenance of energy and oxygen metabolism; the direct antiviral effects of vitamins (reduction of SARS-CoV-2 replication); compensation of chronic comorbidities (thromboembolism, impaired liver and kidney functions, diabetes mellitus, polyneuropathy), which aggravate the course of COVID-19; reducing hyperhomocysteinemia and chronic aseptic inflammation; inhibiting carbonic anhydrases to improve oxygen metabolism in the lungs, and increasing the clearance of lactate from the blood and preventing sepsis. Conclusion. By improving myelination of the olfactory sensory neurons, vitamin B 12 can help overcome anosmia, which occurs in 80% of COVID-19 patients. Short courses (up to 2 – 3 weeks) of high-dose parenteral therapy with thiamine, pyridoxine, and cyanocobalamin can be used as a part of a complex of therapeutic measures to improve clinical outcomes in patients with COVID-19, especially in elderly patients with polyhypovitaminosis, diabetes mellitus, hyperhomocysteinemia, thrombophilia, and high risk of sepsis. Oral therapy with thiamine, pyridoxine, and cyanocobalamin is justified as a part of rehabilitation measures after COVID-19 in patients who have faced its consequences in the form of clinical signs of vitamin B vitamin deficiency.

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Hyperhomocysteinemia, low vitamin B12, and low folic acid: Are risk factors of cerebral vascular thrombosis in northwest Iran?

Cited by 8 publications

References 17 publications

An uncommon presentation of hyperhomocysteinemia and vitamin B12 deficiency: a case report

An uncommon presentation of hyperhomocysteinemia and vitamin B12 deficiency: a case report

Synergistic Effect of Atorvastatin and Folic Acid on Cardiac Function and Ventricular Remodeling in Chronic Heart Failure Patients with Hyperhomocysteinemia

On the prospects for the use of thiamine, pyridoxine, and cyanocobalamin in the complex therapy and rehabilitation of patients with COVID-19

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