Hyperhomocysteinemia, inflammation and autoimmunity

Lazzerini, Pietro Enea; Capecchi, Pier Leopoldo; Selvi, Enrico; Lorenzini, Sauro; Bisogno, Stefania; Gargiulo, Mauro; Laghi-Pasini, Franco

doi:10.1016/j.autrev.2007.03.008

Cited by 111 publications

(109 citation statements)

References 38 publications

Supporting

Mentioning

103

Contrasting

Unclassified

Order By: Relevance

“…Production of homocysteine is associated with proliferating activity of peripheral blood mononuclear cells 42 . Elevation of homocysteine in rheumatoid arthritis, inflammatory bowel disease and Behçet's disease go hand in hand with the elevation of some inflammatory markers and there are evidences that homocysteine plays an immuno-inflammatory activation triggering and/or aggravating role in these diseases 40 .…”

Section: Discussionmentioning

confidence: 99%

“…With its ability to bind to special proteins and to modify them, homocysteine may cause formation of new antigens. There is growing evidence that hyperhomocysteinemia not only represents a risk factor for the development of CVD accompanying inflammatory and autoimmune diseases, but also plays a role in the onset and progression of tissue damage underlying the disease 40 . Homocysteine and its various derivatives have been shown, depending on their concentration, to activate T cells or cause their apoptosis.…”

Section: Discussionmentioning

confidence: 99%

“…In brief, homocysteine is an amino acid, the blood level of which is elevated through immuno-inflammatory activation and which can also cause immuno-inflammatory activation itself initiating autoimmune diseases 40 . In psoriasis, also an inflammatory disease, homocysteinerelated pathogenetic studies are about the DNA methylation which occurs during the homocysteine transformation into methionine.…”

Section: Discussionmentioning

confidence: 99%

“…One of the speculative explanations for not encountering high levels of homocysteine in psoriatic patients in our region may be that they meet their need for large amounts of folic acid through their habit of consuming an abundance of vegetables and herbal foods. Folate and vitamin deficiencies have been observed to accompany hyperhomocysteinemia in inflammatory-autoimmune diseases other than psoriasis 40 . This coexistence has been explained by stating that folate and vitamin B12, which are very vulnerable to oxidation, may have been destroyed due to the oxidative stress caused by inflammation or that the molecules crucial for DNA synthesis and repair may have been depleted by the actively proliferating immune system cells 40 .…”

mentioning

confidence: 99%

See 3 more Smart Citations

Blood homocysteine, folic acid, vitamin B12 and vitamin B6 levels in psoriasis patients

Uslu¹,

Şendur²,

Şavk³

et al. 2017

TURKDERM

View full text Add to dashboard Cite

ÖzBackground and Design: Homocysteine, a sulfur-containing amino acid, is known to be related with autoimmunity-inflammation, cardiovascular disease and DNA methylation. In this case-control study, we aimed to determine plasma homocysteine, folic acid, vitamin B12 and vitamin B6 levels in patients with psoriasis. Materials and Methods: Smoking, alcohol and coffee consumption habits were recorded in adult patients with plaque-type psoriasis and age-and sex-matched controls. Height and weight measurements were performed and Psoriasis Area and Severity Index (PASI) scores were calculated. Fasting venous blood samples were collected to determine homocysteine, folic acid, vitamin B12, vitamin B6, glucose, total cholesterol, triglyceride, high density lipoprotein (HDL), erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) levels. Results: There was no significant difference between psoriasis patients (n=43) and controls (n=47) in body mass index and alcohol and coffee consumption. Smoking rate was significantly high in psoriasis patients. The median PASI score was 10.0 (8.3-12.8). Plasma homocysteine, folic acid, vitamin B12, vitamin B6, total cholesterol, triglyseride, ESR and CRP values were not significantly different between patients and the controls. HDL level was low in psoriasis patients (p=0.001). Plasma homocysteine level was higher in males than in females. There was no relationship of homocysteine levels with patient's age, PASI scores, ESR, CRP values and lipids. Homocysteine levels were inversely related with folic acid and vitamin B12 (p=0.000, r=-0.436, p=0.047, r=-0.204, respectively). We did not find any relationship between homocysteine and vitamin B6 levels. Conclusion: There was no increase in plasma homocysteine levels in psoriasis patients we followed up. Homocysteine level increases in inflammatory disorders and this increase is accepted as a cardiovascular disease marker. Homocysteine homeostasis may be balanced in our patients because of the genetic background and/or nutritional habits in this population Keywords: Psoriasis, homocysteine, folic acid Amaç: Homosistein kardiyovasküler hastalık, otoimmünite-enflamasyon ve DNA metilasyonu ile ilişkilendirilen sülfür içeren bir aminoasittir. Bu olgu-kontrol çalışmasında psoriazisli hastalarda plazma homosistein düzeylerinin ve homosisteini etkileyen folik asit, vitamin B6 ve vitamin B12 düzeylerinin belirlenmesi amaçlanmıştır. Gereç ve Yöntem: Polikliniğimizde takip edilen erişkin plak tip psoriazis hastaları ile yaş ve cinsiyet uyumlu kontrol grubunda alkol, kahve ve sigara tüketimi sorgulandı, katılımcıların boy ve ağırlıkları ölçüldü. Hastaların Psoriazis Alan Şiddet İndeksleri (PAŞİ) hesaplandı. Sabah açlık kan örnekleri alınarak homosistein, folik asit, vitamin B12, vitamin B6, kan şekeri, serum total kolesterol, trigliserid, yüksek yoğunluklu lipoproteinler (HDL), eritrosit sedimantasyon hızı (ESH) ve C-reaktif protein (CRP) değerleri çalışıldı. Bulgular: Psoriazisli hasta (n=43) ve kontrol grubu (n=47) arasında vücut kitle inde...

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Blood homocysteine, folic acid, vitamin B12 and vitamin B6 levels in psoriasis patients

Uslu¹,

Şendur²,

Şavk³

et al. 2017

TURKDERM

View full text Add to dashboard Cite

show abstract

“…Mild hyperhomocysteinemia, defined on the basis of plasma concentration ranging between 16 and 30 umol/L, is independently associated with the development of coronary disease, cerebral and peripheral vascular disease and deep-vein thrombosis in the general population. 20) In the present study, the carotid IMT in the group with the AC genotype was significantly larger than that of the AA genotype group. An increased IMT is associated with vascular risk factors and the development of advanced atherosclerosis, which includes coronary artery diseases.…”

Section: Discussionmentioning

confidence: 49%

Polymorphism of the Angiotensin II Type 1 Receptor A1166C in Korean Hypertensive Adolescents

2008

View full text Add to dashboard Cite

Background and Objectives:The renin-angiotensin system (RAS) is a major regulator of blood pressure. The angiotensin II receptor type 1 (AGTR 1) A1166C has been extensively studied in searching for their involvement in the development of hypertension. The aim of this study was to determine the association of the AGTR 1 A1166C marker with essential hypertension in Korean adolescents. Subjects and Methods: Forty hypertensive adolescents were included in this study. The obesity index (OI) and body mass index (BMI) of the subjects were calculated. Blood pressure was measured at the resting state by oscillometric methods. The serum aldosterone, renin, insulin, angiotensin converting enzyme (ACE), homocysteine, vitamin B 12 and folate levels were measured. The carotid intima-media thickness (IMT) and diameter and the brachial-ankle pulse wave velocity (baPWV) were evaluated by ultrasound. Polymerase chain reaction (PCR) was conducted to amplify the DNA of each of the study subjects to analyze the polymorphism of AGTR 1 A1166C. Results: The genotypic frequency of AA was 87.5%, that for adenylate cyclase (AC) was 12.5% and no CC type was detected. The serum homocysteine level was higher in the subjects with the AC genotype than that in the subjects with the AA genotype (11.9±2.9 umol/L vs 17.1±4.2 umol/L, respectively). The carotid IMT of the subjects with the AA genotype was greater than that of the subjects with the AC genotype (5.0±0.1 mm vs 8.0±0.2 mm, respectively). Conclusion: In conclusion, the A1166C mutation group had a significantly greater carotid IMT and higher homocysteine levels than the group with the normal genotype of AGTR 1. The AC genotype of A1166C may be useful to predict the presence of early coronary artery disease in hypertensive adolescents. More investigation is necessary to clarify the relation between the A1166C gene and its involvement with coronary artery disease in hypertensive Korean adolescents.

show abstract

Self‐Rupturing and Hollow Microcapsules Prepared from Bio‐polyelectrolyte‐Coated Microgels

Geest

Déjugnat

Prevot

et al. 2007

Adv Funct Materials

View full text Add to dashboard Cite

This paper reports on microcapsules obtained by layer‐by‐layer deposition of bio‐polyelectrolyte multilayers at the surface of biodegradable dextran microgels. The behavior of the layer‐by‐layer coating upon degradation of the microgel core strongly depends on the bio‐polyelectrolytes used. Two types of microcapsules, “self‐rupturing” microcapsules and “hollow” microcapsules, are presented. Self‐rupturing microcapsules are obtained when the swelling pressure of the degrading microgel core is strong enough to rupture the surrounding bio‐polyelectrolyte membrane. Self‐rupturing microcapsules could be of interest as a pulsed drug delivery system. Hollow microcapsules are obtained after applying multiple layers of bio‐polyelectrolyte that can withstand the swelling pressure of the degrading microgel core. Biomacromolecules (such as albumin and dextran) spontaneously accumulate in the hollow microcapsules prepared from dex‐HEMA microgels, which could be of interest for drug‐encapsulation purposes.

show abstract

Hyperhomocysteinemia, inflammation and autoimmunity

Cited by 111 publications

References 38 publications

Blood homocysteine, folic acid, vitamin B12 and vitamin B6 levels in psoriasis patients

Blood homocysteine, folic acid, vitamin B12 and vitamin B6 levels in psoriasis patients

Polymorphism of the Angiotensin II Type 1 Receptor A1166C in Korean Hypertensive Adolescents

Self‐Rupturing and Hollow Microcapsules Prepared from Bio‐polyelectrolyte‐Coated Microgels

Contact Info

Product

Resources

About