Hyperhomocysteinemia: Focus on Endothelial Damage as a Cause of Erectile Dysfunction

Salvio, Gianmaria; Ciarloni, Alessandro; Cutini, Melissa; Balercia, Giancarlo

doi:10.3390/ijms22010418

Cited by 23 publications

(18 citation statements)

References 36 publications

(27 reference statements)

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“…Homocysteine (HCY) can inhibit eNOS and promote NOS uncoupling, thereby reducing the production of endothelium‐dependent NO (Musicki et al., 2010). Currently, hyperhomocysteinaemia (HHcy) has also been recognised as an independent risk factor for vascular endothelial dysfunction and ED (Salvio et al., 2021).…”

Section: Introductionmentioning

confidence: 99%

Association between folic acid, homocysteine, vitamin B12 and erectile dysfunction—A cross‐sectional study

et al. 2021

Andrologia

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To evaluate the relationship between serum levels of folic acid (FA), homocysteine (HCY), vitamin B12 (B12) and erectile dysfunction (ED) and to explore their internal relationships. The study included 134 ED patients and 50 healthy controls. ED was assessed using IIEF-5 scores. ED group had lower median FA (6.08 versus 10.21; p < .001) and B12 (256.0 versus 337.5; p < .001) levels, and higher median HCY (11.4 versus 7.95; p < .001) levels, and these differences seemed to be more pronounced in the younger participants (age < 35 yr). FA decreased with the severity of ED (7.52 versus 6.15 versus 5.49 versus 3.97; p < .001), while HCY increased (10.35 versus 11.8 versus 12.9 versus 15; p < .001). Smoking and shift work were associated with lower FA levels. Multivariate analysis showed that serum FA and HCY revealed significant relation with ED. ROC analysis showed that FA ≤ 8.84 and HCY ≥ 10.35 were the best cut-off values for ED diagnosis. Both FA (r = −0.703, p < .001) and B12 (r = −0.576, p < .001) were negatively correlated with HCY. In conclusion, low FA levels and high HCY levels might be independent risk factors for ED. Low serum FA and B12 levels might co-cause high HCY levels and lead to ED.

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Section: Introductionmentioning

confidence: 99%

Association between folic acid, homocysteine, vitamin B12 and erectile dysfunction—A cross‐sectional study

et al. 2021

Andrologia

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“…Also, studies have shown that hyperhomocysteinemia affects the formation and maintenance of a systemic inflammatory response. This was shown by biochemical blood tests of cardiac patients, where overestimated markers of inflammation (interleukin-6, fibrinogen, CRP) were clearly demonstrated [18].…”

Section: The Effect Of Hyperhomocysteinemia On the Cardiovascular Systemmentioning

confidence: 84%

The Role of Hyperhomocysteinemia in the Pathogenesis of Thromboocclusive Diseases

Yusupov

Akaeva

Stepanova

et al. 2021

JPRI

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Homocysteine is a sulfur-containing non-proteinogenic amino acid that is an intermediate product of methionine metabolism. With excessive accumulation of homocysteine in the body, a state of hyperhomocysteinemia occurs, which has attracted the attention of doctors since the middle of the last century and received a serious impetus for research after the publication of data on the role of hyperhomocysteinemia in the pathogenesis of thromboocclusive diseases. To date, there are more than 7.5 thousand scientific papers devoted to the study of hyperhomocysteinemia, monothematic international conferences on clinical and therapeutic aspects of hypermonocysteinemia are held every year. In the Russian Federation, a detailed study of the role of homocysteine and its side effects in excess is of particular interest due to the prevalence of cardiovascular pathologies (according to statistics of the Ministry of Health of Russia-49.27% of deaths of Russians fall on this cohort of diseases). This is an important fact in Russian medicine, which deserves close attention from researchers and scientists.

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“…Carotid IMT (cIMT) has been demonstrated to be associated with atherosclerosis, CVD [55,56], and erectile dysfunction. The latter is a precocious marker of endothelial dysfunction [57,58]. Indeed, subjects with erectile dysfunction present higher cIMT and lower FMD than controls, and these parameters may be improved upon vasodilation induced by treatment with phosphodiesterase 5 inhibitors [59][60][61][62].…”

Section: How To Measure Endothelial Dysfunction: Direct and Indirect mentioning

confidence: 99%

The “Hitchhiker’s Guide to the Galaxy” of Endothelial Dysfunction Markers in Human Fertility

Santi

Spaggiari

Greco

et al. 2021

IJMS

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Endothelial dysfunction is an early event in the pathogenesis of atherosclerosis and represents the first step in the pathogenesis of cardiovascular diseases. The evaluation of endothelial health is fundamental in clinical practice and several direct and indirect markers have been suggested so far to identify any alterations in endothelial homeostasis. Alongside the known endothelial role on vascular health, several pieces of evidence have demonstrated that proper endothelial functioning plays a key role in human fertility and reproduction. Therefore, this state-of-the-art review updates the endothelial health markers discriminating between those available for clinical practice or for research purposes and their application in human fertility. Moreover, new molecules potentially helpful to clarify the link between endothelial and reproductive health are evaluated herein.

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Hyperhomocysteinemia: Focus on Endothelial Damage as a Cause of Erectile Dysfunction

Cited by 23 publications

References 36 publications

Association between folic acid, homocysteine, vitamin B12 and erectile dysfunction—A cross‐sectional study

Association between folic acid, homocysteine, vitamin B12 and erectile dysfunction—A cross‐sectional study

The Role of Hyperhomocysteinemia in the Pathogenesis of Thromboocclusive Diseases

The “Hitchhiker’s Guide to the Galaxy” of Endothelial Dysfunction Markers in Human Fertility

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