Hyperhomocysteinemia, as an Independent Risk Factor for Retinal Venous Occlusion in an Indian Population

Lahiri, Kapil Deb; Dutta, Jayanta; Datta, Himadri; Das, Harendra Nath

doi:10.1007/s12291-012-0238-3

Cited by 14 publications

(19 citation statements)

References 27 publications

(37 reference statements)

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“…[18] HHcys was reported as an independent risk factor for RVO. [9] This study also showed that hcys levels were increased significantly in the patients with RVO as opposed to the control subjects (P < 0.001). (Table-1 predicted that this might correspond to a history or absence of history of asymptomatic myocardial ischemia.…”

Section: Discussionsupporting

confidence: 54%

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Variations in the Natural Course of Elevated Plasma Homocysteine Level Following Retinal Vein Occlusion at Presentation.

Lahiri¹

2017

WJPR

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Purpose:No study has done yet to see the natural course of high homocysteine (HHcys) level following retinal vein occlusion (RVO).Hence our study tried to find out level of Hcys after 1 month of follow up among the RVO with HHcys at presentation. Material & Methods:A total of 37 patients with HHcys on the 2 nd day of presentation in RVO, were reevaluated for fasting plasma Hcys levels on 30 th day in their respective follow up in one year prospective case-control study.No intervention was done to reduce the HHcys during this period.Results: Hcys levels were increased significantly in the patients with RVO (mean total Hcys, 18.16 ± 4.73 μmol/L) as opposed to the control subjects (mean total Hcys, 11.05 ± 2.21 μmol/L; P < 0.001) on 2 nd day of presentation. One month follow up Hcys estimation revealed 22 patients with HHcys (mean total Hcys, 17.16 ± 4.13 μmol/L) and 15 patients with normal Hcys level (mean total Hcys, 11.76 ± 2.93 μmol/L).Conclusions: Elevated Hcys is not only a risk factor for RVO but also a marker of acute retinal vein occlusion hence routine therapy of Hcys lowering agents should be done judiciously in retinal vein occusion patients at presentation.

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Section: Discussionsupporting

confidence: 54%

“…[5][6][7][8] There were reports in support of the hypothesis that HHcys were associated with RVO cases. [9][10][11] Elevated Hcys level can be lowered by folic acid supplementation. [12] But no study has done yet to see the natural course of high Hcys level following RVO.…”

Section: Introductionmentioning

confidence: 99%

Variations in the Natural Course of Elevated Plasma Homocysteine Level Following Retinal Vein Occlusion at Presentation.

Lahiri¹

2017

WJPR

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“…Homocysteine (Hcy), a sulfur-containing amino acid formed during the metabolism of methionine, can be remethylated to methionine throughmethyltetrahydrofolate reductase (MTHFR) [ 8 ]. Several studies have shown that the level of plasma total homocysteine (tHcy) is elevated in RVO patients and it is a risk factor for RVO [ 9 , 10 ]. The MTHFR C677T gene mutation is an important cause of elevated plasma tHcy.…”

Section: Introductionmentioning

confidence: 99%

Homocysteine, methylenetetrahydrofolate reductase C677T polymorphism, and risk of retinal vein occlusion: an updated meta-analysis

Zhou

Peng

et al. 2014

BMC Ophthalmol

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BackgroundTo evaluate the role of plasma total homocysteine (tHcy) and homozygosity for the thermolabile variant of the methylenetetrahydrofolate reductase (MTHFR) C677T genotype in the risk of retinal vein occlusion (RVO).MethodsRelevant studies were selected through an extensive search of PubMed, EMBASE, and the Web of Science databases. Summary weighted mean differences (WMDs) or odds ratios (ORs) and 95% confidence intervals (CI) were calculated with a random-effects model.ResultsForty-two studies with 6445 participants were included in this updated systematic review and meta-analysis. The mean plasma tHcy level in the RVO patients was significantly higher than in the controls (WMD =2.13 μmol/L; 95% CI: 1.29 to 2.98, P < 0.001), but there was evidence of between-study heterogeneity (P < 0.001). No significant association between MTHFR C677T genotype and RVO was found under all genetic models.ConclusionThere was some evidence that plasma tHcy is associated with an increased risk of RVO. There was no evidence to suggest an association between homozygosity for the MTHFR C677T genotype and RVO.

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“…CRVO is increasingly being recognized in younger patients and elevated serum homocysteine is a potential risk factor for the disease. [13][14][15][16][17][18][19][20][21] There is a significant contradictory evidence regarding the role of homocysteine in CRVO in literature. [22][23][24][25][26][27][28][29] Homocysteine is a sulfur-containing amino acid with a free thiol (sulfhydryl; SH) group, formed from methionine in blood and its metabolism is dependent on vitamins or www.djo.org.in Delhi Journal of Ophthalmology vitamin derivatives (folate, vitamin B12, vitamin B6 and flavin adenine dinucleotide).…”

Section: Discussionmentioning

confidence: 99%

“…The role of hyperlipidemia and hyperhomocysteinemia has been evaluated in some studies as a risk factor for RVO of the young, wih contradictory results. [12][13][14] We report a case of CRVO in a young patient with elevated serum homocysteine, with an excellent outcome. We also reviewed the literature on the relationship of hyperhomocysteinemia and CRVO of young.…”

Section: Introductionmentioning

confidence: 99%

Central Retinal Vein Occlusion in young with Hyperhomocysteinemia - A Case Report and Review of Literature

Sami¹,

Sharma²,

Husain³

et al. 2019

DJO

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We present a case of unilateral non-ischemic CRVO in a 22 year male without hypertension, diabetes and open angle glaucoma. Laboratory tests including complete coagulation profile and thrombotic workup were negative, except for raised serum homocysteine level(23.03 µmol/L). The patient was given vitamin supplements for 8 weeks to control homocysteine levels and a single intravitreal bevacizumab injection was given to treat macular edema. The vision and macular thickness improved to normal at 8 weeks, with no recurrence or new cardiovascular complications over a follow-up of one year. We also reviewed the literature and found hyperhomocysteinemia to be a important risk factor for CRVO in the young, and vitamin supplements help in quicker recovery and can prevent recurrence.

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Hyperhomocysteinemia, as an Independent Risk Factor for Retinal Venous Occlusion in an Indian Population

Cited by 14 publications

References 27 publications

Variations in the Natural Course of Elevated Plasma Homocysteine Level Following Retinal Vein Occlusion at Presentation.

Variations in the Natural Course of Elevated Plasma Homocysteine Level Following Retinal Vein Occlusion at Presentation.

Homocysteine, methylenetetrahydrofolate reductase C677T polymorphism, and risk of retinal vein occlusion: an updated meta-analysis

Central Retinal Vein Occlusion in young with Hyperhomocysteinemia - A Case Report and Review of Literature

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