Hyperhomocysteinaemia is an independent risk factor of abdominal aortic aneurysm in a Chinese Han population

Abstract

The associations between hyperhomocysteinaemia (HHcy), methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism, and abdominal aortic aneurysm (AAA) remain controversial, with only few studies focused on these associations within the Chinese population. We performed subgroup and interaction analyses in a Chinese Han population to investigate these associations. In all, 155 AAA patients and 310 control subjects were evaluated for serum total homocysteine levels and MTHFR C677T polymorphisms. Multiple logistic regression models were used to evaluate the aforementioned associations. Interaction and stratified analyses were conducted according to age, sex, smoking status, drinking status, and chronic disease histories. The multiple logistic analyses showed a significant association between HHcy and AAA but no significant association between MTHFR C677T polymorphism and AAA. The interaction analysis showed that age and peripheral arterial disease played an interactive role in the association between HHcy and AAA, while drinking status played an interactive role in the association between MTHFR C677T polymorphism and AAA. In conclusion, HHcy is an independent risk factor of AAA in a Chinese Han population, especially in the elderly and peripheral arterial disease subgroups. Longitudinal studies and clinical trials aimed to reduce homocysteine levels are warranted to assess the causal nature of these relationships

Chronic Kidney Disease Induces Inflammatory CD40 + Monocyte Differentiation via Homocysteine Elevation and DNA Hypomethylation

“…Case subjects had defined clinical and objective investigational evidence of all type of vascular disease in which MC counts and HHcy were identified to be independent risk factors. 24,25,26 Conditions thought to influence Hcy concentrations and MC counts (e.g. recent systemic infection or thyroid disease) served as exclusion criteria for both cases and control subjects.…”

Hyperhomocysteinaemia and vascular injury: advances in mechanisms and drug targets

“…To date, a substantial amount of data from case–control cohort studies and meta‐analyses support the association of HHcy with a range of vascular diseases, including hypertension, ischaemic stroke, aortic aneurysm and dissection, coronary heart disease, coronary artery calcification, vascular dementia and cervical artery dissection. as HHcy has also been identified as a risk factor for these diseases (Fallon and Ben‐Shlomo, ; Ravaglia et al ., ; Takagi and Umemoto, ; Holmes et al ., ; Clarke et al ., ; Liu et al ., , ; Luo et al ., ; Kim et al ., ; Wang et al ., ).…”

Hyperhomocysteinaemia is an independent risk factor for peripheral arterial disease in a Chinese Han population

“…In addition an updated meta-analysis [17] of 14 studies was performed in 2009 confirming the hypothesis that patients with PAD have significantly higher levels of homocysteine. Few similar studies [18, 19] were performed to investigate the association between HHcy and presence of PAD within the Chinese population, which compared to the western population are very different in their lifestyle, nutrition, and metabolism. In addition, the interactions of other cardiovascular risk factors such as age, smoking, and diabetes with HHcy in the development of PAD are still unknown.…”