Hyperhomocysteinaemia in Behcet's disease

Aksu, Kenan; Turgan, Nevbahar; Öksel, Fahrettin; Keser, Gökhan; Özmen, Derya; Kitapçıoğlu, Gül; Gumusdis, G; Bayındır, Özün; Doğanavşargil, Eker

doi:10.1093/rheumatology/40.6.687

Cited by 62 publications

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“…Thus, 4 studies were considered of high quality, 4,24,25,28 whereas the other 12 were considered of low quality. 8,12,26,27,29 -36 Hyperhomocysteinemia Eight studies, 4,12,26,27,30,32,35,36 for a total of 166 patients with thrombosis and 318 patients without thrombosis, were included in the metaanalysis. Definition of hyperhomocysteinemia varied among the studies.…”

Section: Study Qualitymentioning

confidence: 99%

“…Eleven studies, 4,8,12,24,25,[27][28][29][30]32,36 for a total of 236 patients with thrombosis and 518 patients without thrombosis, were included in the metaanalysis. In these patients, mean levels of hcy were significantly higher in patients with thrombosis compared with patients without thrombosis (mean difference 3.30 mol/L; 95% CI 2.09 to 4.51; Figure 3), again suggesting an association between the high levels of hcy and the development of thrombosis.…”

Section: Mean Levels Of Homocysteinementioning

confidence: 99%

“…Given the presence of significant heterogeneity among the studies in the primary analyses, we explored potential sources of heterogeneity, repeating the analyses including only 3 studies 4,35,36 that assessed hcy levels using fluorescent polarizing immunoassay.…”

Section: Sensitivity and Subgroup Analysesmentioning

confidence: 99%

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Homocysteine in Vascular Behçet Disease

Regina

Orlandini

Prisco

et al. 2010

ATVB

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Objective-Behçet disease (BD) is a vasculitis of unknown etiology, characterized by oral or genital aphtosis and uveitis.Homocysteine (hcy) is an independent risk factor for venous and arterial thrombosis. The association between hyperhomocysteinemia and thrombosis has been investigated in some studies in BD patients. However, information on this association is based only on the results of small studies with conflicting results. To overcome such limitations, we performed a metaanalysis comparing the plasma levels of hcy in BD patients with and without history of thrombosis. Methods and Results-We searched for all published studies using the Medline and Embase databases. Two reviewers performed study selection independently. Studies were included if hcy was measured in adult BD patients with and without thrombosis. Two reviewers independently extracted data on study and population characteristics. The mean value of hcy in BD patients and the presence of hyperhomocysteinemia in patients with and without thrombosis were collected. Association between thrombosis and hyperhomocysteinemia, and the mean difference of hcy levels in BD patients with and without thrombosis were calculated. Sixteen studies, for a total of 979 patients, were included. Hyperhomocysteinemia was more prevalent in patients with thrombosis than in those without (odds ratio 3.14; 95% CI 1.26 to 7.80) Mean levels of hcy were significantly higher in patients with thrombosis in comparison with patients without (mean difference 3.30 mol/L; 95% CI 2.09 to 4.51). This high prevalence of thromboses, known since the 1950s, 3 promoted several studies aimed at investigating their pathobiology. Endothelial injury itself, common to other vasculitis, cannot clearly account for thrombosis development, so a hypercoagulable state was early hypothesized and investigated. 4 In the last several years, several inherited or acquired factors causing hypercoagulability have been studied in patients with venous and arterial thromboembolic events. 5-7 These thrombophilic factors have also been studied in patients with BD with a history of thrombosis, and conflicting results were obtained. 8 -11 Recently, Ricart et al performed a metaanalysis evaluating the role of FV Leiden, prothrombin G2021A mutation, and the homozygous 677TT mutation of the methyltetrahydrofolate reductase as risk factors for venous thrombosis in BD patients. 12 In this study, FV Leiden and G2021A prothrombin mutation were found to increase the risk of thrombosis in these patients, whereas 677TT mutation of methyltetrahydrofolate reductase did not. Conclusion-OurThese findings are consistent with the results of recent studies performed in general populations in which the presence of 677TT mutation of methyltetrahydrofolate reductase is not a risk factor for venous thromboembolism in the absence of hyperhomocysteinemia. 13 On the other hand, in the general population, increased levels of homocysteine (hcy) have been reported to be an independent risk factor for venous thromboembolism in addition to c...

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Section: Study Qualitymentioning

confidence: 99%

Section: Mean Levels Of Homocysteinementioning

confidence: 99%

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Homocysteine in Vascular Behçet Disease

Regina

Orlandini

Prisco

et al. 2010

ATVB

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“…16,17 Elevated Hcy has also been reported to be associated with thrombosis in vascular BS in several studies. [18][19][20][21] Cerebral venous sinus thrombosis frequently co-occurs with peripheral venous vascular events such as deep venous thrombosis and pulmonary vascular disease; therefore, serum Hcy levels are expected to be high in vascular NBS. 22 Homocysteine is known to be toxic for endothelial cells and has also been found to be associated with lower cognitive scores and neurological disorders.…”

Section: Discussionmentioning

confidence: 99%

Serum Vitamin B12, Homocysteine and Methylmalonic Acid Levels in Patients With Parenchymal Neuro-Behçet’s Syndrome

et al. 2017

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Objectives: This study aims to investigate the role of serum levels of vitamin B12 (VitB12), homocysteine (Hcy), and methylmalonic acid (MMA) in the development of parenchymal neuro-Behçet's syndrome (NBS) and to compare them with healthy controls and Behçet's syndrome (BS) patients without NBS. Patients and methods: Serum VitB12, Hcy, and MMA were measured using enzyme-linked immunosorbent assay in 64 patients (36 males, 28 females; mean age 36±8.3 years; range 20 to 56 years) who met the criteria of the International Study Group for Behçet's Disease and 30 matched healthy controls (17 males, 13 females; mean age 35.76±9.6 years; range 20 to 50 years). The study participants were grouped as BS patients with NBS, BS patients without NBS, and healthy controls. Results: There was no significant difference between the groups regarding serum VitB12, Hcy, and MMA levels (p>0.05). Serum VitB12 levels were below the lower limit and serum Hcy levels were above the upper limit in all participants. MMA levels were normal in all participants. There was no correlation between the serum levels of VitB12, Hcy, and MMA and disease activity (p>0.05). Conclusion:The results of this study suggest that there is no significant association between VitB12 deficiency and parenchymal NBS. Further studies are needed to investigate the underlying mechanisms of the variable effects of VitB12 deficiency on different clinical manifestations of BS.

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“…Aksu ve ark.nın araştırmasında, BH'de plazma homosistein konsantrasyonu sağlıklı popülasyona göre anlamlı olarak daha yüksektir. [17] Baş-ka bir çalışmada ise homosistein düzeyi derin ven trombozu (DVT) olan BH grubunda DVT olmayan Behçet hastalarından ve sağlıklı popülasyondan daha yüksek bulunmasına rağmen MTHFR genotip dağılımında anlamlı olarak farklılık saptanmamıştır. [18] Ayrıca MTHFR C677T polimorfizmi tek başına homosistein regülasyonunda rol oynayamaz.…”

Section: Olgu Sunumuunclassified

Multiple small bowel perforations due to Behçet's Disease

Eker

Eroğlu

2015

Ulus Travma Acil Cerrahi Derg

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ÖZETBehçet hastalığı, kronik, nükslerle seyreden, pek çok sistemi tutan, idiyopatik enflamatuvar bir hastalıktır. Gastrointestinal sistemde ağızdan sonra en sık tutulum yeri ileoçekal bölgedir. Behçet hastalığının neden olduğu intestinal ülserlerler, perforasyonlara neden olabilmektedir. On dokuz yaşında erkek hasta Behçet hastalığı tanısı ile hastanemize kabul edildi. Hastada akut karın gelişmesi üzerine kliniğimizde ameliyat edildi ve laparotomi sırasında terminal ileumda multipl perforasyonlar olduğu saptandı. Hastaya parsiyel ileum rezeksiyonu yapıldı. Ameliyat sonrası dönemi sorunsuz seyreden hasta taburcu edildi. Hastanın ileostomisi ilk ameliyattan sonraki ikinci ayda kapatıldı. On altı aylık izlem periyodunda hastada klinik olarak önemli bir sorun görülmedi. Bu yazıda Behçet hastalığının tanısı sırasında nadiren görülen bir komplikasyon olan multipl ileum perforasyonu sunuldu ve yayınlanmış olguların bilgisi altında tartışıldı.Anahtar sözcükler: Behçet sendromu; enterobehçet; faktör V Leiden; intestinal perforasyon; MTHFR; tombofili.

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Hyperhomocysteinaemia in Behcet's disease

Abstract: Hyperhomocysteinaemia may be assumed to be an independent risk factor for venous thrombosis in BD. Unlike the factor V Leiden mutation, hyperhomocysteinaemia is a correctable risk factor. This finding might lead to new avenues in the prophylaxis of thrombosis in BD.

Cited by 62 publications

References 0 publications

Homocysteine in Vascular Behçet Disease

Homocysteine in Vascular Behçet Disease

Serum Vitamin B12, Homocysteine and Methylmalonic Acid Levels in Patients With Parenchymal Neuro-Behçet’s Syndrome

Multiple small bowel perforations due to Behçet's Disease

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