Hypergravity, aging and longevity in Drosophila melanogaster

Bourg, Éric Le; Lints, F.A.; Fresquet, Nadine; Bullens, Pol

doi:10.1016/0300-9629(93)90408-v

Cited by 42 publications

(36 citation statements)

References 32 publications

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“…As can be seen from Table 3, there was generally no effect on maximal life span, although in some studies there was an increase in average longevity. This is also consistent with studies in invertebrates (198,261). The extension of maximum life span by SOD mimetic drugs described a few years ago for C. elegans (230) has been unable to be repeated by others either for C. elegans (170) or Drosophila (214).…”

Section: B Antioxidant Defensessupporting

confidence: 89%

Life and Death: Metabolic Rate, Membrane Composition, and Life Span of Animals

Hulbert¹,

Pamplona²,

Buffenstein

et al. 2007

Physiological Reviews

752

725

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Maximum life span differences among animal species exceed life span variation achieved by experimental manipulation by orders of magnitude. The differences in the characteristic maximum life span of species was initially proposed to be due to variation in mass-specific rate of metabolism. This is called the rate-of-living theory of aging and lies at the base of the oxidative-stress theory of aging, currently the most generally accepted explanation of aging. However, the rate-of-living theory of aging while helpful is not completely adequate in explaining the maximum life span. Recently, it has been discovered that the fatty acid composition of cell membranes varies systematically between species, and this underlies the variation in their metabolic rate. When combined with the fact that 1) the products of lipid peroxidation are powerful reactive molecular species, and 2) that fatty acids differ dramatically in their susceptibility to peroxidation, membrane fatty acid composition provides a mechanistic explanation of the variation in maximum life span among animal species. When the connection between metabolic rate and life span was first proposed a century ago, it was not known that membrane composition varies between species. Many of the exceptions to the rate-of-living theory appear explicable when the particular membrane fatty acid composition is considered for each case. Here we review the links between metabolic rate and maximum life span of mammals and birds as well as the linking role of membrane fatty acid composition in determining the maximum life span. The more limited information for ectothermic animals and treatments that extend life span (e.g., caloric restriction) are also reviewed.

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Section: B Antioxidant Defensessupporting

confidence: 89%

Life and Death: Metabolic Rate, Membrane Composition, and Life Span of Animals

Hulbert¹,

Pamplona²,

Buffenstein

et al. 2007

Physiological Reviews

752

725

View full text Add to dashboard Cite

show abstract

“…The increase in the activity of these enzymes and also molecular expression enhance the capacity of an organism to manage oxidative stress and thus improves life expectancy [30,31]. Interestingly, due to tap stress, no significant changes in the activity of SOD and catalase enzyme have been observed in flies with or without any diet supplement of test compounds.…”

Section: Discussionmentioning

confidence: 99%

Effect of Forced Exercise (Tap Stress) on Drosophila Melanogaster and Efficacy of Abhrak Bhasma as Dietary Supplement.

Subedi¹,

Vartak

Kale³

2018

Asian J Pharm Clin Res

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Objective: Generation of reactive oxygen species and other oxidants as an outcome of aerobic respiration has been well documented. During boosted muscular activities/exercise, there is an increase in the rate of respiration and subsequent generation of oxidants; for which, organisms possess various defense systems. There is, however, paucity of reports on the effect of forced exercise in Drosophila melanogaster. Methods:The present investigation reports a method for inducing forced exercise, the "tap stress," in D. melanogaster. This method takes advantage of the natural tendency of Drosophila flies to climb/fly upward in a cylindrical tube. Simplicity of assembly, ease of experimentation and cost effectiveness are some of the key advantages of this method. Tap stress has been assumed to manifest through the generation of oxidative stress, thus, parameters indicative of oxidative stress have been evaluated. Results:The results indicate that tap stress induces oxidative stress mainly by influencing the non-catalytic components; total reduced glutathione (GSH), GSH: oxidized glutathione ratio, and free radical scavenging capacity. The catalytic components (superoxide dismutase, and catalase), on the contrary, remain largely unaffected. Abhrak bhasma (AB) influences total GSH content with an increase by about 38±21%, while flies on control diet register a decrease in total GSH content by 34±7% during tap stress. Feeding flies on AB, specifically, show a prominent increase in the transcription levels of cap "n" collar C, heat shock protein 70 and catalase genes (>1.5 fold). Conclusion:Overall, dietary supplement of AB and ascorbic acid benefits Drosophila flies in the management of oxidative stress induced through tap stress.

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“…The supplementation of antioxidants through diet changes the balance between oxidants and antioxidants, should increases longevity [5]. Many plants are the source of natural antioxidants [6].…”

Section: * Corresponding Authormentioning

confidence: 99%

Asparagus racemosus extract increases the life span in Drosophila melanogaster

Kumar¹,

Prasanna²,

Ashadevi³

2015

J App Biol Biotech

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Free radicals and oxidative stress are recognized as important factors in the biology of aging as well as in many age-related diseases. Dietary antioxidant plays a potential role in the reduction of age-related diseases. Many medicinal plants are rich source of antioxidants and promote longevity. Drosophila is a suitable animal model to study ageing and oxidative study. This study evaluated the antioxidant property of Asparagus racemosus on longevity and G6PD activity in Drosophila melanogaster. The analyses were carried out in stress and non stress conditions. Longevity increased almost by 29% at low concentration and 41% at high concentration in extract supplemented flies. G6PD level was significantly increased in extract supplemented larval stages than adults. The antioxidant property of Asparagus racemosus increases the larval G6PD activity thus; it extends the lifespan in adults.Abbreviation A. racemosus Asparagus racemosus, ACR Acrylamide, OS Oxidative stress, G6PD Glucose 6 Phosphate Dehydrogenase.

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Hypergravity, aging and longevity in Drosophila melanogaster

Cited by 42 publications

References 32 publications

Life and Death: Metabolic Rate, Membrane Composition, and Life Span of Animals

Life and Death: Metabolic Rate, Membrane Composition, and Life Span of Animals

Effect of Forced Exercise (Tap Stress) on Drosophila Melanogaster and Efficacy of Abhrak Bhasma as Dietary Supplement.

Asparagus racemosus extract increases the life span in Drosophila melanogaster

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