Hyperglycemic stress induces oxidative damage of enteric glial cells by triggering redoxosomes/p66SHC activation
Yanmin Jiang,
Lan Xu,
Xue Zhu
et al.
Abstract:Objectives
Diabetic gastrointestinal dysfunction (DGD) is a serious complication of diabetic mellitus (DM), affecting the enteric nervous system (ENS), particular enteric glial cells (EGCs). This study aimed to elucidate the effects and underlying molecular mechanisms of hyperglycemic stress on EGCs in
in vitro
and
in vivo
models of DM.
Methods
In
in vitro
studies, enteric glial cell line C… Show more
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