Hyperglycemic status is associated with an elevated risk of osteoporotic fracture in community-dwelling elderly Japanese men: The Fujiwara-kyo osteoporosis risk in men (FORMEN) cohort study

Iki, Masayuki; Fujita, Yuki; Kouda, Katsuyasu; Yura, Akiko; Tachiki, Takahiro; Tamaki, Junko; Sato, Yuho; Moon, Jong-Seong; Hamada, Minako; Kajita, Etsuko; Okamoto, Nobuhiko; Kurumatani, Norio

doi:10.1016/j.bone.2019.01.005

Cited by 25 publications

(26 citation statements)

References 39 publications

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“…This review highlights the importance of efficient clinical management of patients suffering from diabetes mellitus, since adequately controlled diabetes mellitus has been consistently implicated to have a positive effect on bone health, which reverses bone impairments in some studies [130,189,190,208,226,227,228,229,230]. It is important to bear in mind that patients who are on a treatment regime causing hypoglycemic episodes are at a greater risk of sustaining fractures [231,232,233].…”

Section: Discussionmentioning

confidence: 99%

Impact of Diabetes Mellitus on Bone Health

Murray

Coleman

2019

IJMS

149

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Long-term exposure to a diabetic environment leads to changes in bone metabolism and impaired bone micro-architecture through a variety of mechanisms on molecular and structural levels. These changes predispose the bone to an increased fracture risk and impaired osseus healing. In a clinical practice, adequate control of diabetes mellitus is essential for preventing detrimental effects on bone health. Alternative fracture risk assessment tools may be needed to accurately determine fracture risk in patients living with diabetes mellitus. Currently, there is no conclusive model explaining the mechanism of action of diabetes mellitus on bone health, particularly in view of progenitor cells. In this review, the best available literature on the impact of diabetes mellitus on bone health in vitro and in vivo is summarised with an emphasis on future translational research opportunities in this field.

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Section: Discussionmentioning

confidence: 99%

Impact of Diabetes Mellitus on Bone Health

Murray

Coleman

2019

IJMS

149

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“…In one study the risk of non-vertebral fractures was higher compared to controls only in T2DM men treated with insulin (RR 1.74) (8), but the effect of treatment itself cannot be excluded (see below). In another study on Japanese men those with T2DM had a hazard ratio of 2.76 for fragility fractures compared to normoglycemic men (9). Both longer diabetes duration and poor glycemic control seem associated with a higher fracture risk (10).…”

Section: Fracture Prevalence In Dmmentioning

confidence: 95%

Osteoporosis and Fracture Risk in Patients with Type 2 Diabetes Mellitus

Poiană

Căpățînă

2019

Acta Endo (Buc)

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Type 2 diabetes mellitus (T2DM) is associated with an increased risk of fragility fractures compared to the general population. The pathogenesis of the elevated fracture risk is multifactorial and still largely elusive. In contrast to primary osteoporosis, in T2DM the bone mineral density (BMD) is increased compared to controls, suggesting that specific alterations in bone quality occur in diabetic patients. Even more, the specific increase in BMD observed in these patients impairs at least in part both the classical diagnosis of osteoporosis by dual-energy X-ray absorptiometry (DXA) and the current fracture risk estimation by FRAX (fracture risk assessment tool). Trabecular bone score (TBS) and TBS-adjusted FRAX could improve fracture risk estimation in patients with T2DM but improved tools are needed in the future as well as specific risk stratification criteria. Decreases in the fracture risk of patients with T2DM can be obtained by optimal diabetes control and standard treatment of osteoporosis (most drugs appear to have similar efficacy in patients with T2DM and primary osteoporosis).

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“…Было обнаружено, что у женщин с СД 2-го типа старше 40 лет риск переломов позвоночника и шейки бедра выше, чем у женщин без диабета -на 30% и 82% соответственно [1]. А в исследовании японских авторов (n = 1 951) также было показано, что пожилые мужчины с СД 2-го типа имеют больший риск остеопоретических переломов по сравнению с мужчинами с нормогликемией (HR = 2,76; 95% ДИ: 1,17-6,50 при глюкозе плазмы натощак ≥ 126 мг/дл (≥ 7 ммоль/л); HR = 2,49; 95% ДИ: 1,07-5,77 при HbA1c ≥ 6,5%) [7].…”

Section: эпидемиологияunclassified

“…Рисунок 2. Влияние сахарного диабета 1-го типа на качество костной ткани[7] Figure2. Impact of type 1 diabetes on bone tissue quality[7] …”

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Diabetes mellitus and osteoporosis: pathogenetic relationship and current principles of treatment

Демидова

Плахотняя

2021

Medicinskij sovet

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Diabetes mellitus (DM) is a well known risk factor for osteoporosis and an increased risk of fractures. A lot of data has been published about the relationship between diabetes and bone health. DM type 1 and DM type 2 have different effects on bone mineral density (BMD). The central link in pathogenesis of bone fragility in patients with DM type 1 is a violation of the activity and gifferentiation of osteoblasts. On the contrary, hyperinsulinemia in DM type 2 activates the division and gifferentiation of osteoblasts and contributes to an increase in BMD. However, Higher BMD values in patients with DM type 2 are combined with slowdown in bone metabolism. As the result, high-quality bone remodeling does not occur. And bone strength decreases despite the high BMD. Despite the differences, DM type 1 and DM type 2 have common pathogenic pathways, that lead to increased bone fragility. For example, non-enzymatic glycation of bone matrix collagen and increase in concentration of sclerostin, which blocks the Wnt signaling pathway. In this review, we will analyze current data about epidemiology and pathogenesis of osteoporosis in DM and discuss the practical issues of the clinic, diagnosis, stratification of fracture risk and treatment. Special attention will be paid to the effects of glucose-lowering and anti-osteoporotic drugs on bone tissue.

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Hyperglycemic status is associated with an elevated risk of osteoporotic fracture in community-dwelling elderly Japanese men: The Fujiwara-kyo osteoporosis risk in men (FORMEN) cohort study

Cited by 25 publications

References 39 publications

Impact of Diabetes Mellitus on Bone Health

Impact of Diabetes Mellitus on Bone Health

Osteoporosis and Fracture Risk in Patients with Type 2 Diabetes Mellitus

Diabetes mellitus and osteoporosis: pathogenetic relationship and current principles of treatment

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