Hyperglycemic Crises in Adult Patients With Diabetes

Tanahashi, Hiromichi; Hayashi, Makoto; Yamakita, Noriyoshi

doi:10.2337/dc09-1431

Cited by 11 publications

(5 citation statements)

References 4 publications

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“…In addition, many animal studies have shown that betaine is closely linked with diabetes ( 12 , 153 , 154 ). Diabetes leads to hyperglycemia due to impaired glucose metabolism ( 155 ). Different from its role in obesity, plasma betaine concentration is a poor predictor for diagnosing diabetes in humans ( 137 , 156 , 157 ).…”

Section: Applications Of Betaine In Human Diseasesmentioning

confidence: 99%

Betaine in Inflammation: Mechanistic Aspects and Applications

et al. 2018

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Betaine is known as trimethylglycine and is widely distributed in animals, plants, and microorganisms. Betaine is known to function physiologically as an important osmoprotectant and methyl group donor. Accumulating evidence has shown that betaine has anti-inflammatory functions in numerous diseases. Mechanistically, betaine ameliorates sulfur amino acid metabolism against oxidative stress, inhibits nuclear factor-κB activity and NLRP3 inflammasome activation, regulates energy metabolism, and mitigates endoplasmic reticulum stress and apoptosis. Consequently, betaine has beneficial actions in several human diseases, such as obesity, diabetes, cancer, and Alzheimer’s disease.

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Section: Applications Of Betaine In Human Diseasesmentioning

confidence: 99%

Betaine in Inflammation: Mechanistic Aspects and Applications

et al. 2018

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“…Mutations in KCNQ1 cause cardiac arrhythmia in long QT (LQT) or short QT (SQT) syndromes with or without deafness [3,4] and epilepsy [5]. The channels may be involved in diabetes [6,7] and thyroid gland disorders [8,9]. KCNQ2 and KCNQ3 mutations cause benign familial neonatal epilepsy (BFNS) [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

The Natural Plant Product Rottlerin Activates Kv7.1/KCNE1 Channels

Matschke

Piccini²,

Schubert

et al. 2016

Cell Physiol Biochem

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Background/Aims: Acquired as well as inherited channelopathies are disorders that are caused by altered ion channel function. A family of channels whose malfunction is associated with different channelopathies is the Kv7 K⁺ channel family; and restoration of normal Kv7 channel function by small molecule modulators is a promising approach for treatment of these often fatal diseases. Methods: Here, we show the modulation of Kv7 channels by the natural compound Rottlerin heterologously expressed in Xenopus laevis oocytes and on iPSC cardiomyocytes overexpressing Kv7.1 channels. Results: We show that currents carried by Kv7.1 (EC₅₀ = 1.48 μM), Kv7.1/KCNE1 (EC₅₀ = 4.9 μM), and Kv7.4 (EC₅₀ = 0.148 μM) are strongly enhanced by the compound, whereas Kv7.2, Kv7.2/Kv7.3, and Kv7.5 are not sensitive to Rottlerin. Studies on Kv7.1/KCNE1 mutants and in silico modelling indicate that Rottlerin binds to the R-L3-activator site. Rottlerin mediated activation of Kv7.1/KCNE1 channels might be a promising approach in long QT syndrome. As a proof of concept, we show that Rottlerin shortens cardiac repolarisation in iPSC-derived cardiomyocytes expressing Kv7.1.Conclusion: Rottlerin or an optimized derivative holds a potential as QT interval correcting drug.

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“…AG was calculated as [Na Ϫ (Cl ϩ HCO 3 Ϫ )] and the albumin-corrected AG (AG Corr ) as [AG ϩ 0.25 ϫ (44 Ϫ albumin (g/L)] (mEq/L) (7). The institutional reference value for AG was 14 mEq/L (range, 12-16 mEq/L).…”

Section: Acid-base Analysismentioning

confidence: 99%

“…A lthough diabetic ketoacidosis (DKA) is one of the most common acid-base disturbances in clinical practice to produce a high anion-gap (AG) acidosis, mixed acid-base disturbances are observed in approximately 30% of cases (1)(2)(3). The most frequent of these mixed disturbances is a metabolic alkalosis and vomiting, which is often associated with DKA, and which is one of the most common causes of hypochloremic metabolic alkalosis.…”

mentioning

confidence: 99%