2020
DOI: 10.1002/pbc.28475
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Hyperglycemia requiring insulin during acute lymphoblastic leukemia induction chemotherapy is associated with increased adverse outcomes and healthcare costs

Abstract: Background Hyperglycemia is a complication of induction chemotherapy in 10%‐50% of pediatric patients with acute lymphoblastic leukemia (ALL). Though hyperglycemia in ALL patients is usually transient, it may be associated with adverse health outcomes. However, the risk factors for and consequences of hyperglycemia are poorly understood. We hypothesized that hyperglycemia significant enough to require insulin therapy during induction chemotherapy would be associated with increased morbidity and mortality in pe… Show more

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Cited by 16 publications
(37 citation statements)
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“…Children residing in areas with a median household income in the lower two quartiles faced greater odds of developing hyperglycemia compared to those living in the highest quartile. These findings differ from the secondary analysis of administrative data conducted by McCormick et al (2020) which did not show an association between annual household income and hyperglycemia during ALL treatment. However, in that study, there was no adjustment for the co-morbidity of obesity, a strong predictor of hyperglycemia (McCormick et al, 2020).…”
Section: Discussioncontrasting
confidence: 99%
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“…Children residing in areas with a median household income in the lower two quartiles faced greater odds of developing hyperglycemia compared to those living in the highest quartile. These findings differ from the secondary analysis of administrative data conducted by McCormick et al (2020) which did not show an association between annual household income and hyperglycemia during ALL treatment. However, in that study, there was no adjustment for the co-morbidity of obesity, a strong predictor of hyperglycemia (McCormick et al, 2020).…”
Section: Discussioncontrasting
confidence: 99%
“…These findings differ from the secondary analysis of administrative data conducted by McCormick et al (2020) which did not show an association between annual household income and hyperglycemia during ALL treatment. However, in that study, there was no adjustment for the co-morbidity of obesity, a strong predictor of hyperglycemia (McCormick et al, 2020).…”
Section: Discussioncontrasting
confidence: 99%
See 3 more Smart Citations