Hyperglycemia is associated with simultaneous alterations in electrical brain activity in youths with type 1 diabetes mellitus

Rachmiel, Marianna; Cohen, Michal; Heymen, E.; Lezinger, Mirit; Inbar, Dorrit; Gilat, S.; Bistritzer, Tzvy; Leshem, G.; Kan-Dror, E.; Lahat, Eylon; Ekstein, Dana

doi:10.1016/j.clinph.2015.07.011

Cited by 15 publications

(7 citation statements)

References 39 publications

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“…The data we present here highlight a potential impact of the metabolic state of a participant on measures of brain function. Previous studies have shown that resting EEG power exhibits a non‐linear relationship with BGL in patients with type 1 diabetes (Rachmiel et al., 2016). In healthy control subjects, a small amount of ingested glucose (17 g) has been shown to increase α‐ and θ‐band power 30 min after consumption (An et al., 2015).…”

Section: Discussionmentioning

confidence: 97%

“…One such physiological process that has been largely ignored despite its broad implications is glucose metabolism. Recent studies have suggested spatially unspecific and non‐linear effects of blood glucose level (BGL) on resting EEG (An et al., 2015; Rachmiel et al., 2016). Given the lack of published reports on how blood glucose modulates excitability in terms of aperiodic and periodic signal analysis, we sought to address this fundamental question in an experimenter‐blind study that combined repeated EEG during an adapted glucose tolerance test.…”

Section: Introductionmentioning

confidence: 99%

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Experimental increase of blood glucose alters resting state EEG measures of excitation–inhibition balance

Walker

Buse

Fröhlich

2021

Experimental Physiology

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Brain network oscillations can be divided broadly into periodic and aperiodic signal components, which are sensitive to state-dependent changes in network coordination and excitation-inhibition (E:I) balance. We sought to address whether the dominant energy source of the brain, glucose, is implicated in the regulation of network activity and excitability. We conducted an experimenter-blind, crossover study of the effect of blood glucose level (BGL) on the resting EEG frequency spectrum. Participants consumed a glucose drink (75 g glucose) or an equivalent volume of water on two separate visits. EEG data were sampled before and ≤3 h after the drink. We found that the experimentally induced changes in BGL exhibited an inverted U-shaped relationship, with changes in the individual α frequency peak, whereas the slope of the aperiodic signal component of the frequency spectrum showed a positive linear association suggestive of greater excitation. In contrast, peak α power, which is typically associated with top-down inhibitory processes, was negatively associated with changes in BGL. Collectively, these results suggest that high BGL alters brain network coordination in the form of α oscillations and measures associated with E:I balance.

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Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Experimental increase of blood glucose alters resting state EEG measures of excitation–inhibition balance

Walker

Buse

Fröhlich

2021

Experimental Physiology

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“…It is important to identify the specific factors and regulatory mechanisms associated with MSC aging. Hyperglycemia due to diabetes mellitus and metabolic syndrome is an increasingly occurring health issue that may result in stem cell dysfunction ( 29 , 30 ). Previous reports indicate that hyperglycemia impairs bone marrow hematopoietic functionality and alters the hematopoietic niche ( 31 ) and MSCs cultured in HG-medium have been demonstrated to exhibit premature senescence and telomere alterations ( 17 , 18 , 32 ).…”

Section: Discussionmentioning

confidence: 99%

High glucose induces the aging of mesenchymal stem cells via Akt/mTOR signaling

Zhang

Chen

et al. 2017

Molecular Medicine Reports

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It has previously been demonstrated that glucose is important in the process of stem cell aging. However, the mechanisms of cell senescence induced by high glucose (HG) remain to be elucidated. The preliminary study indicated that D-galactose induced mesenchymal stem cell (MSCs) aging. The present study demonstrated, following treatment with 11.0 or 22.0 mM HG for 14 days, that HG significantly promoted MSCs aging and the expression levels of phosphorylated (p-)phosphatidylinositol 3-kinase/protein kinase B (Akt) and p-mammalian target of rapamycin signaling (mTOR) in the HG groups were increased compared with the control group. However, following Akt inhibition with 1.0 or 10.0 nM MK-2206, which is an Akt-specific small molecule inhibitor, the senescence-cell value in the HG group was significantly decreased compared with the control group. These results indicated that HG induced MSCs senescence and this effect was primarily mediated via the Akt/mTOR signaling pathway.

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“…Diabetes mellitus (DM) as a metabolic syndrome is caused by insulin deficiency or insulin resistance and characterized by chronic hyperglycemia . DM has become a global threat to human health with a projected prevalence of 366 million people in 2030 .…”

Section: Introductionmentioning

confidence: 99%

Sex-Specific Metabolic Changes in Peripheral Organs of Diabetic Mice

Zhang

Ning

et al. 2020

J. Proteome Res.

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Diabetes mellitus (DM) can cause systemic metabolic disorders, but the impact of gender on DM-related metabolic changes is rarely reported. Herein, we analyzed metabolic alterations in the heart, liver, and kidney of male and female mice from normal to diabetes via a 1H NMR-based metabolomics method and aimed to investigate sex-specific metabolic mechanisms underlying the onset and development of diabetes and its complications. Our results demonstrate that male mice had more significant metabolic disorders from normal to diabetes than female mice. Moreover, the kidney was found as the major organ of metabolic disorders during the development of diabetes, followed by the liver and heart. These altered metabolites were mainly implicated in energy metabolism as well as amino acid, choline, and nucleotide metabolism. Therefore, this study suggests that the kidney is the primary organ affected by diabetes in a sex-specific manner, which provides a metabolic view on the pathogenesis of diabetic kidney diseases between genders.

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Hyperglycemia is associated with simultaneous alterations in electrical brain activity in youths with type 1 diabetes mellitus

Cited by 15 publications

References 39 publications

Experimental increase of blood glucose alters resting state EEG measures of excitation–inhibition balance

Experimental increase of blood glucose alters resting state EEG measures of excitation–inhibition balance

High glucose induces the aging of mesenchymal stem cells via Akt/mTOR signaling

Sex-Specific Metabolic Changes in Peripheral Organs of Diabetic Mice

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