Hyperglycemia Is Associated with Impaired Muscle Quality in Older Men with Diabetes: The Korean Longitudinal Study on Health and Aging

Yoon, Ji Won; Ha, Yong Chan; Kim, Kyoung Min; Moon, Jae Hoon; Choi, Sung Hee; Lim, Soo; Park, Young Joo; Lim, Jae Young; Kim, Ki Woong; Park, Kyong Soo; Jang, Hak Chul

doi:10.4093/dmj.2016.40.2.140

Cited by 111 publications

(76 citation statements)

References 29 publications

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“…Therefore, a novel contribution of the present study is that it clarifies a linear relationship between hyperglycemia, as assessed by HbA1c levels, and the frequency of sarcopenia in patients with diabetes. The present results further clarified that the harmful effect of hyperglycemia was specific to SMI and not associated with physical performance, namely grip strength and gait speed, as well as muscle quality; in contrast, previous studies found lower physical performance and physical functional decline in patients with diabetes in comparison with non‐diabetic controls. A reason for the discrepancy might be the different study setting; that is, previous studies found lower physical performance in patients with relatively mild diabetes, suggesting that functional decline in physical performance might precede muscle mass decline.…”

Section: Discussionsupporting

confidence: 75%

“…Previous cross-sectional studies that reported a harmful effect of diabetes on sarcopenia [3][4][5][6]9,10 were based on findings that the frequency of sarcopenia was significantly higher in patients with diabetes than in non-diabetic control participants. However, no studies have reported whether the frequency of sarcopenia was increased by exacerbation of glycemic control in patients with diabetes.…”

Section: Discussionmentioning

confidence: 99%

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Hyperglycemia in non‐obese patients with type 2 diabetes is associated with low muscle mass: The Multicenter Study for Clarifying Evidence for Sarcopenia in Patients with Diabetes Mellitus

Sugimoto

Tabara

Ikegami

et al. 2019

J of Diabetes Invest

103

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Aims/Introduction Hyperglycemia is a risk factor for sarcopenia when comparing individuals with and without diabetes. However, no studies have investigated whether the findings could be extrapolated to patients with diabetes with relatively higher glycemic levels. Here, we aimed to clarify whether glycemic control was associated with sarcopenia in patients with type 2 diabetes. Materials and Methods Study participants consisted of patients with type 2 diabetes (n = 746, the average age was 69.9 years) and an older general population (n = 2,067, the average age was 68.2 years). Sarcopenia was defined as weak grip strength or slow usual gait speed and low skeletal mass index. Results Among patients with type 2 diabetes, 52 were diagnosed as having sarcopenia. The frequency of sarcopenia increased linearly with glycated hemoglobin (HbA1c) level, particularly in lean individuals (HbA1c <6.5%, 7.0%, ≥6.5% and <7.0%: 18.5%; HbA1c ≥7.0% and <8.0%: 20.3%; HbA1c ≥8.0%: 26.7%). The linear association was independent of major covariates, including anthropometric factors and duration of diabetes (HbA1c <6.5%: reference; ≥6.5% and <7.0%: odds ratio [OR] 4.38, P = 0.030; HbA1c ≥7.0% and <8.0%: 4.29, P = 0.024; HbA1c ≥8.0%: 7.82, P = 0.003). HbA1c level was specifically associated with low skeletal mass index (HbA1c ≥8.0%: OR 5.42, P < 0.001) rather than weak grip strength (OR 1.89, P = 0.058) or slow gait speed (OR 1.13, P = 0.672). No significant association was observed in the general population with a better glycemic profile. Conclusions Poor glycemic control in patients with diabetes was associated with low muscle mass.

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Section: Discussionsupporting

confidence: 75%

Section: Discussionmentioning

confidence: 99%

Hyperglycemia in non‐obese patients with type 2 diabetes is associated with low muscle mass: The Multicenter Study for Clarifying Evidence for Sarcopenia in Patients with Diabetes Mellitus

Sugimoto

Tabara

Ikegami

et al. 2019

J of Diabetes Invest

103

View full text Add to dashboard Cite

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“…Diabetic patients were additionally divided into subgroups according to level of metabolic control. HbA1c = 8.5%, similar to the studies by Onishi et al, [38] Yoon et al, [39] Christie et al, [40] and Cakmak et al, [41] was regarded as a reference value. In this way 4 subgroups were created: with good metabolic control HbA1c ≤8.5%, subgroup D1-a, n = 14, mean HbA1c 7.45 ± 1.01%; subgroup D2-a, n = 14, mean HbA1c 7.37 ± 0.78% and poor metabolic control HbA1c >8.5%, subgroup D1-b, n = 16, mean HbA1c 9.75 ± 0.95%; subgroup D2-b, n = 15 mean HbA1c 9.45 ± 0.72%.…”

Section: Methodssupporting

confidence: 62%

Salivary lactate dehydrogenase and aminotransferases in diabetic patients

Malicka

Skośkiewicz−Malinowska

Kaczmarek

2016

Medicine

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Diabetes mellitus (DM) is a group of metabolic diseases resulting from impaired insulin secretion and/or action. DM is characterized by hyperglycemia that can lead to the dysfunction or damage of organs, including the salivary glands.The aim of this study was to compare the levels of salivary lactate dehydrogenase (LDH), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) in diabetic patients.The study was approved by the Bioethics Committee of Wroclaw Medical University (Poland). The study comprised 90 adults of both sexes, aged 21 to 57 years. The patients were divided into 3 groups: type 1 diabetics (D1), type 2 diabetics (D2), and a healthy control group (C). Each group consisted of 30 age- and sex-matched subjects. Total protein (P, by Lowry method), LDH, AST, ALT (with Alpha Diagnostics kits), and salivary flow rate were measured in unstimulated mixed saliva. The level of glycosylated hemoglobin (HbA1c) was measured with DCA 2000 Reagent Kit. The obtained data were analyzed using the Mann–Whitney U test and the Spearman rank at a significance level of P < 0.05 with the use of STATISTICA 9.0 software.In comparison with C, D1 presented a significantly higher activity of LDH (P < 0.001), AST (P < 0.001), and ALT (P < 0.01), whereas D2 indicated higher levels of LDH (P < 0.001) and ALT (P < 0.05) compared with C. Comparing D1 to D2, approximately 3-fold higher activity of AST (P < 0.01) and approximately 4.5-fold higher activity of ALT (P < 0.01) was observed.Higher levels of salivary LDH, AST, and ALT in D1 compared with D2 and C confirm that salivary glands of D1 might be attributed to autoimmunological damage associated with the pathomechanism of DM.

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“…Given that insulin is a potent stimulator of growth and protein synthesis for many cells (8), insufficiency of insulin action in diabetes mellitus likely contributes to muscle mass decline; mouse models in which insulin action is genetically ablated manifest age-dependent decline of muscle mass and physical performance (9,10). Hyperglycemia, a central disorder of diabetes mellitus, is also implicated in the pathogenesis of decline in mass and function of skeletal muscle on the basis of a population-based cohort study and cross-sectional surveys of individuals with type 1 or type 2 diabetes mellitus (5,(11)(12)(13), but the underlying mechanism responsible for this relationship remains unknown.…”

Section: Introductionmentioning

confidence: 99%