Hyperglycemia induces mixed M1/M2 cytokine profile in primary human monocyte-derived macrophages

Moganti, Kondaiah; Li, Feng; Schmuttermaier, Christina; Riemann, Sarah; Klüter, Harald; Gratchev, Alexei; Harmsen, Martin C.; Kzhyshkowska, Julia

doi:10.1016/j.imbio.2016.07.006

Cited by 49 publications

(56 citation statements)

References 39 publications

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“…As expected, the level of IL-1Ra released by all M φ , M1, and M2 macrophages is a response to the expression of IL-1β mentioned above, while the expression of CCL18 was suppressed by hyperglycemia conditions. Elevation of IL-1Ra level was reported to be associated with an elevated risk of type II diabetes, prediabetes, and obesity, and the result showed that hyperglycemia could induce supportive M1/M2 related cytokines to accelerate the progression of diabetes [34]. Therefore, the regulation of M1/M2 polarization can be important to address the issue of obesity, diabetes, and insulin resistance amelioration.…”

Section: Role Of Macrophages In Obesity and Metabolic Diseasesmentioning

confidence: 99%

Chemopreventive Effects of Phytochemicals and Medicines on M1/M2 Polarized Macrophage Role in Inflammation-Related Diseases

Koh

Yang

Lai

et al. 2018

IJMS

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Macrophages can polarize into two different states (M1 and M2), which play contrasting roles during pathogenesis or tissue damage. M1 polarized macrophages produce pro-inflammatory cytokines and mediators resulting in inflammation, while M2 macrophages have an anti-inflammatory effect. Secretion of appropriate cytokines and chemokines from macrophages can lead to the modification of the microenvironment for bridging innate and adaptive immune responses. Increasing evidence suggests that polarized macrophages are pivotal for disease progression, and the regulation of macrophage polarization may provide a new approach in therapeutic treatment of inflammation-related diseases, including cancer, obesity and metabolic diseases, fibrosis in organs, brain damage and neuron injuries, and colorectal disease. Polarized macrophages affect the microenvironment by secreting cytokines and chemokines while cytokines or mediators that are produced by resident cells or tissues may also influence macrophages behavior. The interplay of macrophages and other cells can affect disease progression, and therefore, understanding the activation of macrophages and the interaction between polarized macrophages and disease progression is imperative prior to taking therapeutic or preventive actions. Manipulation of macrophages can be an entry point for disease improvement, but the mechanism and potential must be understood. In this review, some advanced studies regarding the role of macrophages in different diseases, potential mechanisms involved, and intervention of drugs or phytochemicals, which are effective on macrophage polarization, will be discussed.

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Section: Role Of Macrophages In Obesity and Metabolic Diseasesmentioning

confidence: 99%

Chemopreventive Effects of Phytochemicals and Medicines on M1/M2 Polarized Macrophage Role in Inflammation-Related Diseases

Koh

Yang

Lai

et al. 2018

IJMS

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show abstract

“…Our results suggest that BMP‐2 promotes inflammatory responses by interfering with the resolution of inflammatory responses as it obstructs the differentiation of macrophages into the M2 anti‐inflammatory macrophages and this way contribute to the development of atherosclerosis. In line with this, it has been shown that human monocytes and macrophages undergo M1‐like inflammatory polarization when exposed to high levels of glucose on in vitro culture conditions and in patients with hyperglycaemia, suggesting that increased levels of BMP‐2 in T2DM patients may also contribute to the enhancement of inflammatory responses …”

Section: Discussionmentioning

confidence: 60%

“…In line with this, it has been shown that human monocytes and macrophages undergo M1-like inflammatory polarization when exposed to high levels of glucose on in vitro culture conditions and in patients with hyperglycaemia, suggesting that increased levels of BMP-2 in T2DM patients may also contribute to the enhancement of inflammatory responses. [37][38][39][40] The interaction between mononuclear cells and vascular wall facilitates their migration into the plaque microenvironment and the F I G U R E 5 BMP-2 induces endothelial cell adhesiveness in mouse endothelial cells (ECs). A, bEnd5 cells were preincubated with vehicle, 3 μmol/L LDN193189 BMP receptor kinase inhibitor, 1 μmol/L LY29400 PI3K inhibitor, 10 μmol/L SB239063 p38 kinase inhibitor or 25 μmol/L PD98059 MAPK inhibitor and then stimulated with 100 ng/mL BMP-2.…”

Section: Bmp-2 Induces Mononuclear Cell Adhesionmentioning

confidence: 99%

BMP‐2 induces human mononuclear cell chemotaxis and adhesion and modulates monocyte‐to‐macrophage differentiation

Pardali

Makowski

Leffers

et al. 2018

J Cellular Molecular Medi

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Type 2 diabetes mellitus (T2DM) is a cardiovascular risk factor which leads to atherosclerosis, an inflammatory disease characterized by the infiltration of mononuclear cells in the vessel. Bone morphogenetic protein (BMP)‐2 is a cytokine which has been recently shown to be elevated in atherosclerosis and T2DM and to contribute to vascular inflammation. However, the role of BMP‐2 in the regulation of mononuclear cell function remains to be established. Herein, we demonstrate that BMP‐2 induced human monocyte chemotaxis via phosphoinositide 3 kinase and mitogen‐activated protein kinases. Inhibition of endogenous BMP‐2 signalling, by Noggin or a BMP receptor inhibitor, interfered with monocyte migration. Although BMP‐2 expression was increased in monocytes from T2DM patients, it could still stimulate their migration. Furthermore, BMP‐2 interfered with their differentiation into M2 macrophages. Finally, BMP‐2 both induced the adhesion of monocytes to fibronectin and endothelial cells (ECs), and promoted the adhesive properties of ECs, by increasing expression of adhesion and pro‐inflammatory molecules. Our data demonstrate that BMP‐2 could exert its pro‐inflammatory effects by inducing monocyte migration and adhesiveness to ECs and by interfering with the monocyte differentiation into M2 macrophages. Our findings provide novel insights into the mechanisms by which BMP‐2 may contribute to the development of atherosclerosis.

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“…An international research group with Russian participation has put forward an interesting hypothesis [65]. According to this hypothesis, hyperglycemia is the key factor in the pathogenesis of diabetes mellitus.…”

Section: Resultsmentioning

confidence: 99%

“Shielding” of Cytokine Induction by the Periodontal Microbiome in Patients with Periodontitis Associated with Type 2 Diabetes Mellitus

et al. 2019

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Periodontal diseases, especially those with polymicrobial etiology, are often associated with type 2 diabetes mellitus, proceeding more severely and affecting the course of diabetes mellitus. Recently, this feature has been associated with the ability of periodontopathogen microflora to cause not only a local infectious process in the oral cavity, but also to interact with the human immune system and induce various systemic effects. We investigated changes in the salivary cytokine profile of patients with chronic periodontitis, associated and not associated with type 2 diabetes mellitus. We observed a statistically significant decrease of MCP-1/CCL2, GM-CSF, IL-5, IL-6, and IFN- in the saliva of patients with chronic periodontitis associated with type 2 diabetes mellitus in comparison with patients with chronic periodontitis only. All of these cytokines are associated with macrophage activation. These data are an important contribution to the elucidation of the mechanism of periodontopathogens involvement in the manifestation of the systemic effects of type 2 diabetes.

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Hyperglycemia induces mixed M1/M2 cytokine profile in primary human monocyte-derived macrophages

Cited by 49 publications

References 39 publications

Chemopreventive Effects of Phytochemicals and Medicines on M1/M2 Polarized Macrophage Role in Inflammation-Related Diseases

Chemopreventive Effects of Phytochemicals and Medicines on M1/M2 Polarized Macrophage Role in Inflammation-Related Diseases

BMP‐2 induces human mononuclear cell chemotaxis and adhesion and modulates monocyte‐to‐macrophage differentiation

“Shielding” of Cytokine Induction by the Periodontal Microbiome in Patients with Periodontitis Associated with Type 2 Diabetes Mellitus

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