Hyperglycemia-induced oxidative stress in the development of diabetic foot ulcers

Bolajoko, Elizabeth Bosede; Akinosun, Olubayo Michael; Khine, Aye Aye

doi:10.1016/b978-0-12-815776-3.00004-8

Cited by 12 publications

(9 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Therefore, the hyperglycemia-induced wound healing impairment can also be corroborated by a reduction in MMPs expression (Lan et al, 2008(Lan et al, , 2009. Since the hyperglycemic microenvironment underlying DFU enhances the production of reactive oxygen species (ROS) (Bolajoko et al, 2020), detection of ROS serves as an ideal marker to confirm the hyperglycemia-induced oxidative stress and impairment in wound healing (Buranasin et al, 2018;Lamers et al, 2011;Xuan et al, 2014). Glycation of skin collagen that forms AGE is one of the hallmarks that represent the hyperglycemic condition underlying DFU (Lyons & Basu, 2012).…”

Section: Two-dimensional Cell Culture Modelmentioning

confidence: 99%

A review of diabetic wound models—Novel insights into diabetic foot ulcer

Phang

Arumugam

Kuppusamy

et al. 2021

J Tissue Eng Regen Med

View full text Add to dashboard Cite

Diabetic foot ulcer (DFU) is a major debilitating complication of diabetes. Many research investigations have been conducted with the aims to uncover the diabetic wound healing mechanisms, develop novel therapeutics, and screen bioactive wound dressings in order to improve the current management of DFU. These would have not been possible without the utilization of an appropriate wound model, especially in a diabetic wound context. This review focuses on the different in vitro research models used in DFU investigations such as the 2D scratch wound assay, 3D skin model, and 3D angiogenesis model as well as their limitations. The current efforts and challenges to apply the 2D and 3D in vitro models in a hyperglycemic context to provide insights into DFU modeling will be reviewed. Perspectives of utilizing 3D bioprinting and skin-on-the-chip model as a diabetic wound model in the future will also be highlighted. By leveraging knowledge from past experiences and current research, an improved experimental model for DFU is anticipated to be established in near future.

show abstract

Section: Two-dimensional Cell Culture Modelmentioning

confidence: 99%

A review of diabetic wound models—Novel insights into diabetic foot ulcer

Phang

Arumugam

Kuppusamy

et al. 2021

J Tissue Eng Regen Med

View full text Add to dashboard Cite

show abstract

“…The chronic exposure of RBCs to elevated glucose levels leads to various biochemical and physiological changes that contribute to oxidative stress and impair RBC function. [29] Elevated blood glucose levels promote the non-enzymatic HbA1c within RBCs. This process leads to the formation of HbA1c, which serves as a marker for long-term glucose control.…”

Section: Role Of Hyperglycemia In Inducing Oxidative Stress and Impac...mentioning

confidence: 99%

Red blood cells as biomarkers and mediators in complications of diabetes mellitus: A review

Obeagu

2024

Medicine

View full text Add to dashboard Cite

Red blood cells (RBCs), traditionally recognized for their oxygen transport role, have garnered increasing attention for their significance as crucial contributors to the pathophysiology of diabetes mellitus. In this comprehensive review, we elucidate the multifaceted roles of RBCs as both biomarkers and mediators in diabetes mellitus. Amidst the intricate interplay of altered metabolic pathways and the diabetic milieu, RBCs manifest distinct alterations in their structure, function, and lifespan. The chronic exposure to hyperglycemia induces oxidative stress, leading to modifications in RBC physiology and membrane integrity. These modifications, including glycation of hemoglobin (HbA1c), establish RBCs as invaluable biomarkers for assessing glycemic control over extended periods. Moreover, RBCs serve as mediators in the progression of diabetic complications. Their involvement in vascular dysfunction, hemorheological changes, and inflammatory pathways contributes significantly to diabetic microangiopathy and associated complications. Exploring the therapeutic implications, this review addresses potential interventions targeting RBC abnormalities to ameliorate diabetic complications. In conclusion, comprehending the nuanced roles of RBCs as biomarkers and mediators in diabetes mellitus offers promising avenues for enhanced diagnostic precision, therapeutic interventions, and improved patient outcomes. This review consolidates the current understanding and emphasizes the imperative need for further research to harness the full potential of RBC-related insights in the realm of diabetes mellitus.

show abstract

“…Dibandingkan dengan tukak neuropati, bisul yang dihasilkan dari insufisiensi arteri membawa risiko kekambuhan dan amputasi yang lebih tinggi (Woody, 2020). Penelitian (Bolajoko et al, 2020) 2,34). Oleh karena itu, risiko UKD lebih tinggi pada pasien yang memiliki durasi DM yang lama (>10 tahun) (P <0,001, OR = 8,56) dan untuk durasi pasien diabetik serta perokok menyatakan hasil yang signifikan dengan enam kali lebih banyak pada perokok daripada yang tidak merokok (P <0,001, OR = 6), hampir lima kali lebih banyak pada pasien yang kehilangan sensasi sentuhan (P <0,001, OR = 4,95), dan delapan kali lebih banyak pada pasien yang memiliki HbA1c > 7,5% (P < 0,001, OR = 8,10).…”

Section: Pendahuluanunclassified

Kajian Pustaka Tentang Hubungan Perawatan Kaki Dengan Terjadinya Ulkus Kaki Diabetik Pada Pasien Diabetes Melitus Type 2

Muslik¹,

Agustina²,

Lumadi³

2022

Mal Nurse J.

View full text Add to dashboard Cite

Diabetes mellitus is a lifelong condition which is one of the leading causes of death in the world. Approximately 15% of patients with diabetes mellitus will suffer from diabetic foot ulcers. The incidence of lower extremity amputation associated with diabetic foot ulcers was significantly inversely correlated with the provision of foot care services. The purpose of this study was to determine the relationship between foot care and the occurrence of foot ulcers in patients with Type 2 Diabetes Mellitus based on literature studies in the last 5 years. Literature review is carried out based on issues, methodologies, similarities and further research proposals. Of the 11 articles, it shows that one researcher conducted a design using case control, one researcher used the cohort study method, while three researchers used a quasi experiment (pre-post test with control design), one researcher used a questionnaire design and five researchers used a cross sectional study ( documentation studies). The population is all patients with diabetes mellitus. Based on 11 studies, it was found that there was a significant relationship between foot care and the occurrence of foot ulcers in patients with Type 2 Diabetes Mellitus. people with type 2 DM. Given the high prevalence of UKD in patients with type 2 diabetes, it is recommended that they perform routine foot care. Keywords: Diabetes Mellitus, Diabetic Foot Ulcers, Foot CareABSTRAK ABSTRAK Diabetes melitus adalah kondisi seumur hidup yang merupakan salah satu penyebab utama kematian di dunia. Sekitar 15% pasien diabetes melitus akan menderita ulkus kaki diabetik. Insiden amputasi ekstremitas bawah terkait ulkus kaki diabetes secara signifikan berkorelasi terbalik dengan penyediaan layanan perawatan kaki. Tujuan dari penelitian ini adalah untuk mengetahui hubungan perawatan kaki dengan terjadinya ulkus kaki pada pasien dengan Diabetes Mellitus Type 2 berdasarkan studi literatur dalam 5 tahun terakhir. Literatur review dilakukan berdasarkan issue, metodologi, persamaan dan proposal penelitian lanjutan. Dari 11 artikel menunjukan terdapat satu peneliti melakukan desain dengan menggunakan case control, satu peneliti menggunakan metode cohort study sedangkan tiga peneliti menggunakan quasy experiment (pre-post test with control design), satu peneliti dengan menggunakan kuesioner design dan lima peneliti menggunakan cross sectional study (studi dokumentasi). Populasinya adalah seluruh pasien diabetes melitus. Berdasarkan 11 penelitian didapatkan bahwa ada hubungan yang signifikan antara perawatan kaki dengan terjadinya ulkus kaki pada pasien dengan Diabetes Mellitus Type 2. Hubungan kejadian UKD dengan perawatan kaki cukup signifikan dengan arah hubungan negatif yang bermakna semakin buruk perilaku merawat kaki maka akan semakin tinggi kejadian UKD pada orang dengan DM tipe 2. Mengingat tingginya prevalensi UKD pada pasien DM tipe 2 maka disarankan agar melakukan perawatan kaki secara rutin. Kata Kunci: Diabetes Melitus, Ulkus Kaki Diabetic, Perawatan Kaki

show abstract

Hyperglycemia-induced oxidative stress in the development of diabetic foot ulcers

Cited by 12 publications

References 42 publications

A review of diabetic wound models—Novel insights into diabetic foot ulcer

A review of diabetic wound models—Novel insights into diabetic foot ulcer

Red blood cells as biomarkers and mediators in complications of diabetes mellitus: A review

Kajian Pustaka Tentang Hubungan Perawatan Kaki Dengan Terjadinya Ulkus Kaki Diabetik Pada Pasien Diabetes Melitus Type 2

Contact Info

Product

Resources

About