Hyperglycemia-induced oxidative stress exacerbates mitochondrial apoptosis damage to cochlear stria vascularis pericytes via the ROS-mediated Bcl-2/CytC/AIF pathway
Tian-feng Shi,
Zan Zhou,
Wen-jun Jiang
et al.
Abstract:Objectives:
Diabetes is closely linked to hearing loss, yet the exact mechanisms remain unclear. Cochlear stria vascularis and pericytes (PCs) are crucial for hearing. This study investigates whether high glucose induces apoptosis in the cochlear stria vascularis and pericytes via elevated ROS levels due to oxidative stress, impacting hearing loss.
Methods:
We established a type II diabetes model in C57BL/6J mice and used auditory brainstem response (ABR), Evans blue st… Show more
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