Hyperglycemia in sepsis is a risk factor for development of type II diabetes

Gornik, Ivan; Vujaklija, Ana; Lukić, Edita; Madzarac, Goran; Gašparović, Vladimir

doi:10.1016/j.jcrc.2009.10.002

Cited by 39 publications

(30 citation statements)

References 40 publications

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“…Both hyperglycaemia and hypertriacylglycerolaemia have been observed in animals following LPS infusion [21][22][23], as well as in patients with sepsis or other infectious disorders [24,25]. Our study, at a population level, indicated that exposure to increased LBP may contribute to increased 6 year incidence of hyperglycaemia and hypertriacylglycerolaemia, the latter showing the strongest association with baseline LBP levels among all of the MetS components.…”

Section: Discussionmentioning

confidence: 51%

Lipopolysaccharide binding protein, obesity status and incidence of metabolic syndrome: a prospective study among middle-aged and older Chinese

Liu

Pang

et al. 2014

Diabetologia

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Aims/hypothesis Although microbiota-derived endotoxaemia has previously been shown to induce metabolic disorders, data from population-based longitudinal studies are scarce. This study therefore investigated the associations between lipopolysaccharide binding protein (LBP) levels and 6 year incident metabolic syndrome (MetS), as well as the potentially modifying effects of obesity status in middle-aged and older Chinese men and women. Methods A total of 2,529 men and women aged 50-70 years from Beijing and Shanghai, China, were followed for 6 years. Those free of MetS at baseline (1,312) were included in the analyses for the risk of developing MetS. Baseline plasma LBP was measured using an ELISA kit.Results During the 6 year follow-up, 449 (34.2%) participants developed MetS. Baseline LBP was significantly associated with BMI, waist circumference, blood lipid profile and C-reactive protein (CRP) both at baseline and during follow-up (all p<0.05). The RR for incident MetS comparing extreme quartiles of LBP was 1.28 (95% CI 1.04, 1.58), after multivariate adjustment including BMI and CRP. In stratified analysis, LBP was positively associated with incident MetS only in normal-weight participants (RR, comparing extreme tertiles, 1.59; 95% CI 1.18, 2.15; p trend =0.002), but not in their overweight/obese counterparts (RR, comparing extreme tertiles, 0.99; 95% CI 0.80, 1.22; p trend =0.880). A significant interaction was observed between LBP and obesity status ( p interaction =0.013). Conclusions/interpretation Our study suggested that elevated plasma LBP was associated with an increased risk of developing MetS among middle-aged and older Chinese, especially in normal-weight individuals.

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Section: Discussionmentioning

confidence: 51%

Lipopolysaccharide binding protein, obesity status and incidence of metabolic syndrome: a prospective study among middle-aged and older Chinese

Liu

Pang

et al. 2014

Diabetologia

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“…The development of hyperglycaemia during acute inflammation represents significantly higher risk for type 2 diabetes development [2,3]. Figure 2 and Table 3 show differences in the abundance of derived structural features of plasma protein N-glycans between individuals who developed hyperglycaemia during acute condition and their control groups.…”

Section: Analysis Of Plasma N-glycome Composition In the Acuteinflammmentioning

confidence: 99%

“…It was shown recently that individuals without a history of diabetes but who developed hyperglycaemia (plasma glucose > 7.7 mmol/l) during critical illness, were at significantly increased risk of developing type 2 diabetes [2,3]. The RR of type 2 diabetes development during 5 years after the acute illness was 5.6 (95% CI 3.1, 10.2).…”

Section: Introductionmentioning

confidence: 99%

Increased plasma N-glycome complexity is associated with higher risk of type 2 diabetes

et al. 2017

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Aims/hypothesis Better understanding of type 2 diabetes and its prevention is a pressing need. Changes in human plasma Nglycome are associated with many diseases and represent promising diagnostic and prognostic biomarkers. Variations in glucose metabolism directly affect glycosylation through the hexosamine pathway but studies of plasma glycome in type 2 diabetes are scarce. The aim of this study was to determine whether plasma protein N-glycome is changed in individuals who are at greater risk of developing type 2 diabetes. Methods Using a chromatographic approach, we analysed Nlinked glycans from plasma proteins in two populations comprising individuals with registered hyperglycaemia during critical illness (increased risk for development of type 2 diabetes) and individuals who stayed normoglycaemic during the same condition: AcuteInflammation (59 cases (ORCADES and SABRE populations) all presented with increased branching, galactosylation and sialylation of plasma protein N-glycans and these changes were of similar magnitude. Conclusions/interpretation Increased complexity of plasma N-glycan structures is associated with higher risk of developing type 2 diabetes and poorer regulation of blood glucose levels. Although further research is needed, this finding could offer a potential new approach for improvement in prevention of diabetes and its complications.

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“…Some reports suggest that glucose homeostasis recovers completely,23 while others demonstrate that it is persistent in a considerable proportion of patients 24–28. A recent study has also shown that patients with ‘transient’ hyperglycaemia in acute illness are at increased risk of developing DM 29. Further, the time course of prediabetes and DM after an episode of AP remains unclear, as does the influence of AP aetiology and severity.…”

Section: Introductionmentioning

confidence: 99%

Newly diagnosed diabetes mellitus after acute pancreatitis: a systematic review and meta-analysis

Das

Singh

Phillips

et al. 2013

Gut

322

256

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Hyperglycemia in sepsis is a risk factor for development of type II diabetes

Cited by 39 publications

References 40 publications

Lipopolysaccharide binding protein, obesity status and incidence of metabolic syndrome: a prospective study among middle-aged and older Chinese

Lipopolysaccharide binding protein, obesity status and incidence of metabolic syndrome: a prospective study among middle-aged and older Chinese

Increased plasma N-glycome complexity is associated with higher risk of type 2 diabetes

Newly diagnosed diabetes mellitus after acute pancreatitis: a systematic review and meta-analysis

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