Hyperglycemia crisis in head and neck cancer patients with platinum-based chemotherapy

Abstract

Hyperglycemic crisis after cisplatin may be underestimated and may lead to a life-threatening condition. We suggest regular weekly follow-ups of serum glucose level after platinum-based chemotherapy for early detection of hyperglycemia and prevention of a life-threatening crisis.

New onset of type 2 diabetes after colorectal cancer diagnosis: Results from three prospective US cohort studies, systematic review, and meta-analysis

“… 33 , 34 Moreover, synthetic steroids such as dexamethasone, which are widely used drugs to accompany chemotherapy use in CRC patients, may impair glucose metabolism and exacerbate insulin resistance. 35 , 36 Hyperglycaemia is also reported to be associated with platinum-based chemotherapy, 37 , 38 which may not only have a toxic effect on pancreatic β cells, but also inhibit the glycolytic enzymes, contributing to inhibition of insulin. Given the interrelated conditions and bidirectional effects between metabolic disturbance and cancer, more experimental studies are needed to further understand the mechanisms of T2D development in CRC patients.…”

Evaluation of the diabetes contribution to the occurrence of treatment related toxicities in multimodal treated locally advanced head and neck cancers

“…Huang et al reports from a total of 185 patients, 3.8% who developed type 2 diabetes after initial chemotherapy. 3 patients developed diabetic ketoacidosis and the hyperglycemic crisis in this study group, complications occurring in patients with multiple comorbidities 20 . Intrinsic factors have been associated with acute skin toxicity in breast cancer radiotherapy 21 .…”