Hyperglycemia associated with olanzapine treatment

Kumar, PN Suresh; Thomas, Biju

doi:10.4103/0019-5545.82562

Cited by 4 publications

(3 citation statements)

References 8 publications

(6 reference statements)

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“…This case highlights that severe olanzapine-induced hyperglycemia can be fully reversed with olanzapine discontinuation. 14 Patients should be closely monitored through a multidisciplinary lens. If antibodies are negative, physicians can slowly reduce and eventually omit insulin based on glycemic levels and introduce metformin therapy until HgbA1c is less than 6% to reduce insulin resistance.…”

Section: Discussionmentioning

confidence: 99%

Olanzapine-Induced Diabetic Ketoacidosis: A Reversible Etiology Overlooked in Psychiatric Patients

Jain,

Shah,

Bhat

2023

AACE Clinical Case Reports

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Section: Discussionmentioning

confidence: 99%

Olanzapine-Induced Diabetic Ketoacidosis: A Reversible Etiology Overlooked in Psychiatric Patients

Jain,

Shah,

Bhat

2023

AACE Clinical Case Reports

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“…Olanzapine is an atypical antipsychotic which mediates its effects by serotonin-dopamine antagonism. It has been hypothesized that serotonin antagonism results in reduced glucose responsiveness of the pancreatic beta-cells [ 5 - 6 ]. This explains olanzepine’s diabetogenic effect, as was observed in our patient.…”

Section: Discussionmentioning

confidence: 99%

“…Hyperglycemia has been observed as early as 10 days after initiation of olanzapine [ 6 ]. Although our patient had symptoms suggestive of a hyperglycemic state for the past few years, she was only diagnosed with diabetes during her pre-operative review.…”

Section: Discussionmentioning

confidence: 99%

Olanzapine-induced Cataract in a Teenage Girl

2018

Cureus

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Cataract, defined as cloudiness of the lens, is a common adverse effect of first-generation antipsychotic medications. Newer generation antipsychotics, also known as atypical antipsychotics, are less commonly associated with cataract. A 19-year-old girl with underlying schizophrenia on olanzapine for the past two years complained of gradual blurring of vision in both eyes for four months prior to presentation. On examination, the best corrected visual acuity was counting finger in both eyes. The anterior segment examination showed bilateral diffuse cortical cataract precluding fundus examination. Systemic examination was unremarkable. Blood investigations revealed a high random blood sugar, which normalised after she was initiated on oral hypoglycemic medication. After bilateral lens aspiration, her visual acuity was 6/6 bilaterally. Olanzapine may be cataractogenic via its action as a serotonin antagonist, which results in reduced glucose responsiveness of the pancreatic beta-cells. Patients on anti-psychotic medication are at risk of developing diabetes mellitus and cataract compared to the general population. Screening for diabetes mellitus should be part of the follow-up of these patients. Ophthalmological evaluation is warranted in the presence of visual complaints.

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