Hyperglycemia associated with increased hepatic glycogen phosphorylase and phosphoenolpyruvate carboxykinase in rats following subchronic exposure to malathion

Abdollahi, Mohammad; Donyavi, Mohadeseh; Pournourmohammadi, Shirin; Saadat, Maryam

doi:10.1016/j.cca.2004.03.009

Cited by 120 publications

(93 citation statements)

References 30 publications

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“…Similar mechanisms may be involved for other organophosphates (16,17). In our study we did not find an increased risk of GDM among women who reported agricultural exposures during pregnancy and ever-use of malathion (Fig.…”

Section: Discussionsupporting

confidence: 65%

Pesticide Exposure and Self-Reported Gestational Diabetes Mellitus in the Agricultural Health Study

et al. 2007

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OBJECTIVE -To examine the association between pesticide use during pregnancy and gestational diabetes mellitus (GDM) among wives of licensed pesticide applicators.RESEARCH DESIGN AND METHODS -Using data from the Agricultural Health Study (AHS), we estimated the association between self-reported pesticide-related activities during the first trimester of the most recent pregnancy and GDM among 11,273 women whose pregnancy occurred within 25 years of enrollment.RESULTS -A total of 506 (4.5%) women reported having had GDM. Women who reported agricultural pesticide exposure (mixing or applying pesticides to crops or repairing pesticide application equipment) during pregnancy were more likely to report GDM (odds ratio [OR] 2.2 [95% CI 1.5-3.3]). We saw no association between residential pesticide exposure (applying pesticides in the home and garden during pregnancy) and GDM (1.0 [0.8 -1.3]). Among women who reported agricultural exposure during pregnancy, risk of GDM was associated with ever-use of four herbicides (2,4,5-T; 2,4,5-TP; atrazine; or butylate) and three insecticides (diazinon, phorate, or carbofuran).CONCLUSIONS -These findings suggest that activities involving exposure to agricultural pesticides during the first trimester of pregnancy may increase the risk of GDM. Diabetes Care 30:529 -534, 2007

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Section: Discussionsupporting

confidence: 65%

Pesticide Exposure and Self-Reported Gestational Diabetes Mellitus in the Agricultural Health Study

et al. 2007

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“…Our findings were in accordance with other studies carried out in rats and which have also reported an hyperglycemia and a decreased content of liver glycogen and TG in rats exposed to pesticides (Kalender et al, 2005;Elsharkawy et al, 2013). The increased levels of blood glucose may be explained by stimulation of glycogenolysis in several organs (Abdollahi et al, 2004;Pournourmohammadi et al, 2005) and gluconeogenesis in liver (Abdollahi et al, 2004), provoking the release of glucose into the blood and which might be the reason of the significant decrease in liver glycogen content. Also, treatment of rats with DDT may increase the activity of the hepatic gluconeogenic enzyme and phosphoenol pyruvate carboxykinase leading to hyperglycemia.…”

Section: Discussion:-supporting

confidence: 93%

Adverse Haemato-Biochemical Effects of Chlorinated Insecticide in Adult Male Rats.

Marouani¹,

Hallègue²,

Sakly³

et al. 2016

IJAR

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“…It is estimated that the number of people who suffer from type 2 diabetes will rise from 171 million in 2000 to 366 million in 2030 (16). Many studies corroborate that OP exposure might contribute to type 2 diabetes (17)(18)(19)(20)(21)(22)(23)(24)(25). Although the overall evidence of neurological and neurobehavioral effects of long-term OP exposure is thought to be small, it is not that diffi cult to fi nd some (26,27).…”

mentioning

confidence: 99%

Neurocognitive, Mental Health, and Glucose Disorders in Farmers Exposed to Organophosphorus Pesticides

Malekirad

Faghih

Mirabdollahi

et al. 2013

Archives of Industrial Hygiene and Toxicology

Self Cite

104

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About 25 million agricultural workers in the developing world suffer from at least one episode of poisoning each year, mainly by anticholinesterase-like organophosphates (OPs). The objective of this cross-sectional study was to establish the OP toxicity in 187 occupationally exposed farmers in terms of neurocognitive impairment, mental health status, clinical symptoms, diabetes, and haematological factors. The exposed group was compared to 187 healthy age-, sex-, and education-matching controls. Neurocognitive impairment was measured using the Subjective Neurocognition Inventory (SNI) and mental health status using the General Health Questionnaire-28 (GHQ-28). The subjects were also tested for fasting blood glucose (FBG), blood urea nitrogen (BUN), cholesterol (CL), triglycerides (TG), creatinine, oral glucose tolerance test (GTT), high-density lipoprotein (HDL), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP). The exposed farmers showed higher FBG (p<0.001), BUN (p=0.007), CL (p<0.001), oral GTT (p<0.001), and lower AST (p<0.001), ALP (p<0.001), and creatinine (p=0.004) than controls. The rates of anxiety/ insomnia and severe depression were also signifi cantly higher in the farmers than in controls (p=0.015 and p<0.001, respectively). Meanwhile, the rate of social dysfunction was signifi cantly lower than in controls (p<0.001). Disorders affecting psychomotor speed, selective attention, divided attention, verbal memory, nonverbal memory, prospective memory, spatial functioning, and initiative/energy were all lower in the farmers (p<0.001). Farmers showed clinical symptoms eczema, saliva secretion, fatigue, headache, sweating, abdominal pain, nausea, superior distal muscle weakness, inferior distal muscle weakness, inferior proximal muscle weakness, breath muscle weakness, hand tingling, foot tingling, epiphoria, polyuria, miosis, dyspnoea, bradycardia, and rhinorrhoea, which all signifi cantly correlated with the number of working years. These fi ndings indicate that farmers who work with OPs are prone to neuropsychological disorders and diabetes.

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Hyperglycemia associated with increased hepatic glycogen phosphorylase and phosphoenolpyruvate carboxykinase in rats following subchronic exposure to malathion

Cited by 120 publications

References 30 publications

Pesticide Exposure and Self-Reported Gestational Diabetes Mellitus in the Agricultural Health Study

Pesticide Exposure and Self-Reported Gestational Diabetes Mellitus in the Agricultural Health Study

Adverse Haemato-Biochemical Effects of Chlorinated Insecticide in Adult Male Rats.

Neurocognitive, Mental Health, and Glucose Disorders in Farmers Exposed to Organophosphorus Pesticides

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